Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Some evidence suggests that strategies which target multiple factors simultaneously may prove more effective than those focusing on a single mechanism or domain.
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Although a link between body mass index (BMI) and brain volume has been established in several cross-sectional studies, evidence of the association between change in BMI over time and changes in brain structure is limited.
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Prevalence of ACPs and formal authorization of a legal representative was low among the deceased NH residents in Flanders, Belgium.
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A range of medical and neurologic disorders occurs more frequently in people with epilepsy than in the general population and constitutes its somatic comorbidity.
Why it matters
This review notes that dementia and Alzheimer's disease occur more frequently in people with epilepsy and are also risk factors for seizures, suggesting a bidirectional association and shared disease mechanisms. It reports no treatment, cure, or prevention for Alzheimer's disease.
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The Memory and Aging Project is a longitudinal, epidemiologic clinical-pathologic cohort study of common chronic conditions of aging with an emphasis on decline in cognitive and motor function and risk of Alzheimer’s disease (AD).
Why it matters
Summarizes the design of the Rush Memory and Aging Project, a longitudinal clinical-pathologic cohort study of aging focused on cognitive and motor decline and risk of Alzheimer's disease, and presents its findings on motor function, risk factors and brain pathology.
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Systematic cognitive training produces long-term improvement in cognitive function and less difficulty in performing activities of daily living.
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Functional decline is significantly associated with end-of-life hospital use among older adults.
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Many studies have explored whether depression in MCI increased the conversion rate to dementia, but findings are inconsistent.
Why it matters
This review reports that depression is a common risk factor, prodrome and accompanying symptom in Alzheimer's dementia, but that the mechanisms are unknown. It states that studies of antidepressants for depression in dementia are inconclusive, with several large recent studies finding no benefit over placebo.
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These methods may be used to improve accuracy, sensitivity and specificity of Dementia predictions from neuropsychological testing.
Why it matters
This study compared data mining and machine learning methods for predicting dementia using neuropsychological tests. It found that all classifiers performed better than chance alone, but it is about prediction methods, not treatment, cure or prevention.
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Our comparative study of psychometric properties of instruments allows for informed selection of QOC and QOD measures for LTC residents with dementia.
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47/100
To record sleep, actigraph devices are worn on the wrist and record movements that can be used to estimate sleep parameters with specialized algorithms in computer software programs.
Why it matters
This review describes wrist actigraphy, a device worn on the wrist to estimate sleep patterns, and notes it has been studied in the context of dementia. It is a monitoring method, not a treatment, cure or prevention for Alzheimer's disease.
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It was hypothesized that race or ethnicity, social support, and functional status are independently associated with treatment intensity and controlling for regional characteristics, and that individual characteristics account for a substantial proportion of expenditure variation.
Why it matters
This study found that dementia was associated with lower medical expenditures in the last 6 months of life. It does not test any treatment, cure, or prevention for Alzheimer's disease.
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Higher adherence to the MeDi is associated with reduced cerebrovascular disease burden.
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A common but significant change associated with aging is a profound disruption to the daily sleep-wake cycle.
Why it matters
This review notes that sleep problems are common in older adults and that poor sleep is linked to worse health outcomes and possibly to cognitive changes with age. It does not test any treatment, so it cannot say whether improving sleep prevents or treats Alzheimer's disease.
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In most of these nonacademic healthcare delivery systems, traditional randomized clinical trial designs to evaluate effectiveness are too rigid, too expensive, and take too long to achieve results.
Why it matters
This article describes the CareMore model of chronic disease care, reporting lower rehospitalization rates and estimated health spending below regional averages. It does not address treating, curing, or preventing Alzheimer's disease.
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All low-income countries and 59% of the middle-income countries in our sample were found to have far fewer professionals than they need to deliver a core set of mental health interventions.
Why it matters
This analysis estimated that low- and middle-income countries have far fewer mental health professionals than needed to deliver a core set of interventions, including for dementia. The countries sampled would need to add about 239,000 full-time equivalent professionals to address the current shortage.
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47/100
Also, patients with MS who engaged in more cognitive leisure were able to withstand more severe brain atrophy at a given cognitive status.
Why it matters
This study in people with multiple sclerosis found that premorbid cognitive leisure was associated with better current cognitive status independent of brain atrophy. It relates to the cognitive reserve hypothesis, which is also studied in Alzheimer's disease, but it does not test a treatment, cure, or prevention for Alzheimer's disease.
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Patients with Parkinson's disease (PD) often have cognitive deficits from the time of diagnosis.
Why it matters
This study examined the link between cognition and daily function in 111 patients with Parkinson's disease with and without dementia. It is about Parkinson's disease and does not test any treatment, cure, or prevention for Alzheimer's disease.
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47/100
Parkinson's disease (PD) has been associated with mild cognitive impairment (PDMCI) and with dementia (PDD).
Why it matters
This imaging study compared brain structures in people with Parkinson's disease with and without dementia and found no hippocampal differences between groups, but did find caudate atrophy in those with dementia. It is about understanding brain changes in Parkinson's disease dementia, not about treating, curing or preventing Alzheimer's disease.
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Primary progressive aphasia (PPA) is a disorder of declining language that is a frequent presentation of neurodegenerative diseases such as frontotemporal lobar degeneration.
Why it matters
This review describes that primary progressive aphasia is a frequent presentation of neurodegenerative diseases and that specific variants are associated with underlying pathologies, although many cases have unexpected pathology. It expresses hope that adding biomarker assessments to clinical examination will enable accurate diagnosis during life and serve as a basis for clinical trials.
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The increase in life expectancy can influence the prevalence of dementias in the population.
Why it matters
This study reviewed Mini-Mental State Examination cut-off values adjusted for schooling in 968 people in southern Brazil. It is about making the test fairer across education levels and does not test any treatment, cure, or prevention.
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After 2 years, 34 subjects (16%) were lost for follow-up.
Why it matters
This study followed 209 people with mild cognitive impairment for two years to describe their outcomes, finding that 4.5% of those followed up improved to normal. It is an observational outcome study and does not test any treatment, cure, or prevention.
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Individuals with dementia may be receiving different end-of-life care from those without.
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Several recent studies have shown that dementia is common in Parkinson's disease (PD), and that in some patients, cognitive impairment occurs even at the time of diagnosis.
Why it matters
This review reports that dementia is common in Parkinson's disease, with about 30% point prevalence and at least 75% of patients who survive more than 10 years developing it. It describes who is at higher risk and when dementia appears, but offers no treatment, cure, or prevention.
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47/100
Animal studies have suggested that fine particulate matter (PM) can translocate from the upper respiratory tract to the brain and cause brain inflammation.
Why it matters
In 399 older women, long-term exposure to traffic-related particulate matter was associated with worse performance on cognitive tests, suggesting a possible link to mild cognitive impairment. This is an observational finding and does not prove that air pollution causes Alzheimer's disease or that reducing exposure prevents it.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Empowering Family Care Partners to Optimize Delirium Care for Persons Living With Dementia
- Prevalence of post-stroke cognitive impairment in china: a community-based, cross-sectional study
- Exposure to ambient air pollution and the incidence of dementia: A population-based cohort study
- Vitamin D: a d-lightful solution for health
- The Association of Age at Diagnosis of Hypertension With Brain Structure and Incident Dementia in the UK Biobank
- Measuring Mindfulness: Differences in the 15-Item Five Facet Mindfulness Questionnaire in Black and White Dementia Caregivers
- Rivastigmine for dementia associated with Parkinson's disease
- Combined prevalence of frailty and mild cognitive impairment in a population of elderly Japanese people
- UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age
- Adherence to the Mediterranean Diet is Associated with Better Sleep Quality in Italian Adults