Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Dementia patients frequently die after a pneumonia or prolonged intake problems.
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Cognitive dysfunction and dementia have recently been proven to be common (and underrecognized) complications of diabetes mellitus (DM).
Why it matters
This review describes how prediabetes, diabetes, and the metabolic syndrome are associated with increased risk of cognitive decline and dementia, including Alzheimer's disease, and discusses possible mechanisms such as advanced glycation endproducts, oxidative stress, and insulin resistance. It is a summary of evidence and hypotheses, not a report of a treatment or cure.
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This study (n=161) related morphometric MR imaging, FDG-PET and APOE genotype to memory scores in normal controls (NC), mild cognitive impairment (MCI) and Alzheimer's disease (AD).
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Dementia caregiving has been associated with negative effects on caregiver health and early nursing home placement for dementia patients.
Why it matters
This review found that dementia caregiving is linked to negative effects on caregiver health and earlier nursing home placement, and that individually developed multicomponent interventions can reduce burden and improve quality of life. It does not test any treatment, cure, or prevention for Alzheimer's disease itself.
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Educational level was an independent predictor of end-of-life preferences after hearing a verbal description of advanced dementia.
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The prevalence of idiopathic normal-pressure hydrocephalus (NPH) in a community was investigated by retrospective analysis of data from a previous community-based study of 170 randomly selected elderly residents aged 65 years or older.
Why it matters
In this small community sample of 170 older Japanese residents, 2.9% had brain imaging signs and clinical features consistent with idiopathic normal-pressure hydrocephalus. This is a prevalence finding from one rural community and does not show a treatment or cure for Alzheimer's disease.
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45/100
Aging is accompanied by cognitive decline in a major segment of the population and is the primary risk factor for Alzheimer's disease and other prevalent neurodegenerative disorders.
Why it matters
This review discusses how normal brain aging transitions to pathological aging and notes that toxic protein aggregates including amyloid beta-protein are potential contributory factors in Alzheimer's disease. It is a discussion of mechanisms and does not report a tested treatment, cure, or prevention.
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Clinical, neuropsychological, and imaging profiles can contribute to accurate antemortem diagnosis in FTD.
Why it matters
In 61 autopsy-confirmed cases, this study identified clinical, neuropsychological and MRI features that help distinguish tau-positive frontotemporal dementia, tau-negative frontotemporal dementia and frontal-variant Alzheimer disease. These findings are about improving diagnosis of these conditions, not about treating, curing or preventing Alzheimer's disease.
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Impaired ability to conduct daily activities is a diagnostic criterion for dementia and a determinant of healthcare services utilization and caregiver burden.
Why it matters
This study of 124 elderly people found that greater executive dysfunction at initial assessment was associated with more rapid decline in instrumental activities of daily living. It is about predicting functional decline and does not test any treatment or cure.
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Obesity has been related to the incidence of dementia but its impact on cognitive performance in persons without dementia is less clear.
Why it matters
This study examined whether mid-life obesity and high blood pressure relate to cognitive test scores in people without dementia. It is observational, so it cannot show that losing weight or lowering blood pressure prevents cognitive decline.
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The prospective association between adiposity and dementia differs depending on the anthropometric measure used, and is modified by age.
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The increasing age of the population around the world has meant that greater attention is being paid to disorders that mainly affect older people.
Why it matters
This paper discusses the complexity of preventive studies of dementia, arguing that they must account for stage of life, survival and mortality, and population context. It raises questions that need to be explored rather than reporting any treatment, cure or prevention.
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Mild cognitive impairment refers to the transitional state between the cognitive changes of normal aging and the fully developed clinical features of dementia.
Why it matters
This is a review of mild cognitive impairment that discusses clinical criteria, outcomes, predictors of progression, and lessons from completed clinical trials. It presents no new treatment, cure, or prevention results of its own.
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This report reviews the state of the literature and opportunities for research related to the cognitive correlates of functional status.
Why it matters
This review found that the variance in functional status specifically attributable to cognition is surprisingly modest, and that some measures of executive control function and general cognitive screening tests are relatively strong correlates of functional capacities. These findings are relevant to dementia case finding, epidemiology and treatment, but the review reports no treatment or cure.
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People can improve their processing speed at home using readily available technology.
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Caregivers of FTD patients were overall more distressed by the behaviour of their partners than were the caregivers of AD patients.
Why it matters
Comparing 47 spouse caregivers of Alzheimer's patients with 27 spouse caregivers of frontotemporal dementia patients, those caring for frontotemporal dementia patients reported higher general burden and felt less competent. Caregivers of frontotemporal dementia patients were overall more distressed by their partner's behavior, highlighting the need to consider diagnosis when supporting caregivers.
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Schizophrenia and psychotic bipolar disorder are characterized by morphometric distinctions in ventricular and hippocampal regions.
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Approximately half of the care providers evaluated both scales as being good measures of pain and easy to use.
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This article presents a three-factor anatomical model of human idea generation and creative drive, focusing on interactions between the temporal lobes, frontal lobes, and limbic system.
Why it matters
This article presents a three-factor anatomical model of idea generation and creative drive involving temporal lobes, frontal lobes, and the limbic system, drawing on imaging, drug, and lesion evidence. It offers no treatment, cure, or prevention for Alzheimer's disease.
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Parkinson disease (PD) and Alzheimer disease (AD), the two most common neurodegenerative disorders in American adults, are of purely genetic origin in a minority of cases and appear in most instances to arise through interactions among genetic and environmental factors.
Why it matters
This article hypothesizes that early-life environmental exposures may contribute to neurodegenerative disease and reviews evidence such as lead exposure being linked to dementia risk in workers. It is a hypothesis and review, not a study showing that any exposure causes Alzheimer's disease or that avoiding exposures prevents it.
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With increasing emphasis on early diagnosis of Alzheimer disease (AD), clinical research has focused on the identification of risk factors that may be modified at a preclinical and early clinical stage of dementing disorders.
Why it matters
This review focuses on how vascular risk factors such as cholesterol, hypertension and atherosclerosis, along with the APOE4 allele, have been linked to a higher risk of Alzheimer's disease and to conversion from mild cognitive impairment to dementia. It discusses the possible role of these modifiable factors in age-related cognitive decline, but as a review it does not test any treatment or prevention.
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Individuals with Down syndrome (DS) are at a high risk for developing Alzheimer disease (AD) after the age 40; however, low levels of intellectual functioning, coupled with impaired language ability, confound the detection of AD.
Why it matters
In 20 adults with Down syndrome, age was linked to performance on some memory tasks, but other clinical measures were stronger predictors. This is a small study and does not test any treatment or cure.
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This pilot project demonstrates that a staff educational program on end-of-life care for dementia residents can improve end-of-life knowledge and attitudes among long-term care ancillary staff and that this improvement can be maintained for up to 1 year.
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The diagnosis of neurosyphilis can be made with reasonable certainty if there is an appropriate neuropsychiatric syndrome associated with a positive CSF VDRL.
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While great strides have been made recently in improving end-of-life care in the United States, people with dementia often die with inadequate pain control, with feeding tubes in place, and without the benefits of hospice care.
Why it matters
This paper describes barriers to good end-of-life care for people with dementia, including that dementia is often not viewed as a terminal illness and that patients may die with inadequate pain control or feeding tubes. It suggests ways to improve care at the end of life, not to treat, cure or prevent the disease.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- SYNERGIC TRIAL (SYNchronizing Exercises, Remedies in Gait and Cognition) a multi-Centre randomized controlled double blind trial to improve gait and cognition in mild cognitive impairment
- Palliative care and quality of life for people with dementia: medical and psychosocial interventions
- The comprehensive process model of engagement
- Loneliness among dementia caregivers: evaluation of the psychometric properties and cutoff score of the Three-item UCLA Loneliness Scale
- MINDSETS: Multi-omics Integration with Neuroimaging for Dementia Subtyping and Effective Temporal Study
- Neural Plastic Effects of Cognitive Training on Aging Brain
- Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study
- Effects of functional tasks exercise on cognitive functions of older adults with mild cognitive impairment: a randomized controlled pilot trial
- Advanced Glycation End Products (AGEs) May Be a Striking Link Between Modern Diet and Health
- Genetic and Lifestyle Risks for Coronary Artery Disease and Long-Term Risk of Incident Dementia Subtypes