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Association between frailty and the progression trajectories of stroke and dementia comorbidity: insights from observational and genetic analyses
Dongze Chen, Yali Zhang, Zhiqiang Ji, Yi Zhou, Zhisheng Liang. Archives of Gerontology and Geriatrics, 2025-04-21
Topic: Risk, prevention and care in population studies
The final analysis included 459,924 participants. In comparison to the robust, the frail group significantly elevated the risk of transitioning from enrollment to stroke [HR(95 %CI): 2.32(2.19-2.45)], from enrollment to dementia [2.56(2.31-2.83)], from enrollment to mortality [2.32(2.23-2.42)], from stroke to stroke-dementia comorbidity [1.59(1.23-2.05)], from dementia to stroke-dementia comorbidity [1.79(1.29-2.48)], and from stroke to mortality [1.25(1.11-1.40)]. MR analyses revealed that genetically predicted FI was causally associated with higher risks of stroke-dementia comorbidity. PAF analyses indicated that hypertension, diabetes, lung disease, and visual impairment were significant contributors to the risk of progression to stroke-dementia comorbidity. Our findings revealed that frailty status increases the risk of post-stroke dementia, offering important insights for the clinical management and public health strategies.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Chen, D., Zhang, Y., Ji, Z., Zhou, Y., & Liang, Z. (2025). Association between frailty and the progression trajectories of stroke and dementia comorbidity: insights from observational and genetic analyses. Archives of Gerontology and Geriatrics. https://doi.org/10.1016/j.archger.2025.105862
Vancouver
Chen D, Zhang Y, Ji Z, Zhou Y, Liang Z. Association between frailty and the progression trajectories of stroke and dementia comorbidity: insights from observational and genetic analyses. Archives of Gerontology and Geriatrics. 2025. doi:10.1016/j.archger.2025.105862. PMID: 40262338.
BibTeX
@article{chen2025-40262338,
author = {Chen, Dongze and Zhang, Yali and Ji, Zhiqiang and Zhou, Yi and Liang, Zhisheng},
title = {{Association between frailty and the progression trajectories of stroke and dementia comorbidity: insights from observational and genetic analyses}},
journal = {Archives of Gerontology and Geriatrics},
year = {2025},
doi = {10.1016/j.archger.2025.105862},
pmid = {40262338},
url = {https://doi.org/10.1016/j.archger.2025.105862}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- The final analysis included 459,924 participants.
- In comparison to the robust, the frail group significantly elevated the risk of transitioning from enrollment to stroke [HR(95 %CI): 2.32(2.19-2.45)], from enrollment to dementia [2.56(2.31-2.83)], from enrollment to mortality [2.32(2.23-2.42)], from stroke to stroke-dementia comorbidity [1.59(1.23-2.05)], from dementia to stroke-dementia comorbidity [1.79(1.29-2.48)], and from stroke to mortality [1.25(1.11-1.40)].
- MR analyses revealed that genetically predicted FI was causally associated with higher risks of stroke-dementia comorbidity.
- PAF analyses indicated that hypertension, diabetes, lung disease, and visual impairment were significant contributors to the risk of progression to stroke-dementia comorbidity.
- Our findings revealed that frailty status increases the risk of post-stroke dementia, offering important insights for the clinical management and public health strategies.
Why it matters
In this large study, frail participants had higher risks of progressing to stroke, dementia, and combined stroke-dementia, and genetic analysis linked predicted frailty to higher stroke-dementia risk. It suggests frailty status raises the risk of post-stroke dementia, with hypertension, diabetes, lung disease and visual impairment as notable contributors.
Study details
- Participants459,924
- Evidence strengthModerate
How this study scored 44/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Archives of Gerontology and Geriatrics) |
| Journal's citation record | 1 / 4 | Archives of Gerontology and Geriatrics: journal h-index 132 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 4 / 4 | 459,924 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 4 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 2.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Zhisheng Liang: h-index 12 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Peking University: institution h-index 1,098 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40262338) |
| Free to read | 2 / 2 | Free to read |
| Total | 44 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/j.archger.2025.105862
- PubMed: 40262338
- Original source →
- Free full text: Archives of Gerontology and Geriatrics →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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