Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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High neutrophil counts, an easily accessible inflammation biomarker, are associated with atherosclerosis in experimental studies.
Why it matters
This study investigated associations between neutrophil counts and nine cardiovascular endpoints using observational and genetic approaches. It concerns cardiovascular disease, not Alzheimer's disease, and does not address treating, curing or preventing dementia.
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55/100
Prevalence studies indicate that as many as 50% of older adults experience bothersome pain on a regular basis (Dahlhamer et al., 2018; Galicia-Castillo & Weiner, 2023; Larsson et al., 2017; Lin et al., 2020; Rikard et al., 2023).
Why it matters
This introduction to a special issue summarizes research on pain and pain management in older adults, noting that chronic pain is linked to problems such as reduced mobility and falls. It contains no findings on treating, curing, or preventing Alzheimer's disease.
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The average detection rates for mild cognitive impairment is 0.08 (interquartile range=0.00-0.02) for both clinicians and practices, suggesting that only about 8% of expected cases were diagnosed on average.
Why it matters
This study found that only about 8% of expected mild cognitive impairment cases were diagnosed in primary care, with only 0.1% of clinicians and practices having diagnosis rates within the expected range. It concludes that mild cognitive impairment is vastly underdiagnosed and that early detection in primary care needs improvement.
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Among 454,508 beneficiaries diagnosed with ADRD in 2017, 250,837 (55%) were in TM and 203,671 (45%) in MA.
Why it matters
In 454,508 Medicare beneficiaries diagnosed with dementia in 2017, hospital and outpatient use looked similar in traditional Medicare and Medicare Advantage in the months before diagnosis. In the diagnosis month, though, 36.5% of traditional Medicare enrollees were hospitalized versus 25.4% in Medicare Advantage, and use stayed higher in traditional Medicare for many months. One-year mortality was also higher in traditional Medicare (27.9% vs 22.2%), but much of that gap tracked hospitalization at diagnosis. The authors say quality of life and caregiver burden still need to be compared before judging which plan serves people with dementia better.
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After decades of development, researchers have made great progress in the molecular mechanisms of sleep and wakefulness, the pathogenesis of sleep disorders and the development of new therapies.
Why it matters
This review is about the development of sleep medicine in China, not about treating, curing or preventing Alzheimer's disease. It provides no Alzheimer's-specific findings.
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To evaluate characteristics of Medicare beneficiaries associated with practices and clinicians offering telephone visits only and patients receiving telephone visits only, when both telephone and video were available.
Why it matters
This study examined which Medicare beneficiaries were offered or chose telephone-only virtual visits when video was also available, with dementia among the clinical factors considered. It is about telemedicine access, not about treating, curing, or preventing Alzheimer's disease.
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Increasing neighborhood disadvantage was associated with increased risk of EHR-documented dementia diagnosis or dementia-related death (most vs. least disadvantaged ADI quintile HR = 1.76, 95% confidence interval = 1.69-1.84) after adjusting for age and sex.
Why it matters
This study found that increasing neighborhood disadvantage was associated with a higher risk of dementia diagnosis or dementia-related death, and that it accounted for part of the racial and ethnic differences in dementia burden. It is an observational study and does not show that reducing neighborhood disadvantage would prevent or treat Alzheimer's disease.
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Observational population studies indicate that prevention of dementia and cognitive decline is being accomplished, possibly as an unintended result of better vascular prevention and healthier lifestyles.
Why it matters
This report recommends that memory clinics be redesigned as Brain Health Services that assess genetic and modifiable risk factors, communicate risk, and deliver multi-domain risk reduction and cognitive and physical training. It proposes a roadmap for validating and then deploying these services, but does not itself test whether they prevent dementia.
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55/100
Dementia constitutes a worldwide concern.
Why it matters
This study characterized age- and sex-specific modifiable risk factor profiles for dementia in UK Biobank participants. It examined socioeconomic, lifestyle, and health condition factors in relation to incident dementia.
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Biomarkers for the early detection of dementia risk hold promise for better disease monitoring and targeted interventions.
Why it matters
This study examined whether a brain-age measure is linked to progression to dementia in memory clinic patients, using a sample meant to be more representative of real clinics. It is about early detection of dementia risk, not about treating, curing or preventing the disease.
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Care networks ranged from 1 to 8 members.
Why it matters
This feasibility study tested a web-based platform to support caregivers of people with Alzheimer's disease and related dementias, not a treatment for the disease itself. It found the platform acceptable and feasible and reported increased caregiver confidence, but it does not address treating, curing, or preventing Alzheimer's disease.
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There is emerging evidence that obstructive sleep apnea (OSA) is a risk factor for preclinical Alzheimer's disease (AD).
Why it matters
This workshop report says obstructive sleep apnea may be a risk factor for preclinical Alzheimer's disease and that CPAP is the most studied treatment, though cognitive improvements vary across studies. It calls for more research, including sleep-dependent memory tasks and plasma biomarkers, so it offers no confirmed way to prevent or treat dementia yet.
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Higher vitamin D status has been suggested to have beneficial effects on the brain.
Why it matters
This study used observational and Mendelian randomization analyses to examine vitamin D, brain imaging features, and risk of dementia and stroke. It does not show that taking vitamin D prevents dementia, and the findings are about associations and genetic proxies rather than treatment.
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analysis of returning home at discharge included 87,797 patients; 57,104 (65%) were discharged home.
Why it matters
This study looked at which patients return home after a hip fracture, and found that cognitive impairment and malnutrition were linked to a lower chance of going home. It does not test any treatment for Alzheimer's disease itself, but it identifies factors that may affect care and recovery for people with cognitive problems after a fracture.
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While a growing body of evidence points to potentially modifiable individual risk factors for dementia, the built and social environments in which people develop and navigate cognitive decline are largely overlooked.
Why it matters
This study proposes a theoretical concept called Cognability and found that neighborhood features such as access to civic and social organizations, recreation centers, and arts centers were associated with cognitive function in older adults. It is an observational analysis and does not test whether changing neighborhoods would prevent or treat dementia.
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The proposed approach offers a fully automated identification of MCI and dementia based on a recorded neuropsychological test, providing an opportunity to develop a remote screening tool that could be adapted easily to any language.
Why it matters
This study developed a natural language processing approach to detect mild cognitive impairment and dementia from voice recordings of neuropsychological tests. It achieved high accuracy in differentiating normal cognition from dementia, but it is a screening tool, not a treatment or cure.
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Because it is a potentially modifiable metabolic state, with multiple peripheral and central targets for intervention, it may represent a target for alleviating parkinsonian symptoms and slowing progression to disability and dementia. © 2022 The Authors.
Why it matters
This study found that people with Parkinson's disease and type 2 diabetes had more severe motor and non-motor symptoms than those without diabetes. The findings are about Parkinson's disease and do not directly address treating, curing, or preventing Alzheimer's disease.
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Social isolation and loneliness have been associated with increased risk of dementia, but it is not known whether this risk is modified or confounded by genetic risk of dementia.
Why it matters
In 155,070 UK Biobank participants, social isolation and loneliness were linked to higher dementia incidence, and the study examined whether genetic risk for Alzheimer's disease changed or explained this link. It reports associations only and does not show that reducing isolation prevents dementia.
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Intracranial atherosclerotic stenosis (ICAS) is one of the most frequent causes of stroke worldwide and confers one of the greatest risks of recurrent stroke compared with other causes of stroke.
Why it matters
This review states that asymptomatic intracranial atherosclerotic stenosis is increasingly recognised as a risk factor for silent brain infarctions and dementia. It notes that despite current secondary stroke prevention therapies, the risk of recurrent stroke in patients with 70-99% stenosis exceeds 20% at 1 year, and better therapies are urgently needed.
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ADRD prevalence was 5.5%. A total of 25,278 individuals had an incident ADRD code (rate: 1.2%) over the study period-nearly half during a hospital-based encounter.
Why it matters
This study found that Alzheimer's disease and related dementias is under-diagnosed in an integrated health care delivery system compared to traditional Medicare, and diagnosed well beyond the early stages. It suggested that strategic targets for care improvement could focus on generating pragmatic evidence on the value of proactive detection and tracking, care planning, and the role of specialists in chronic care management.
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Multiple factors combined are currently recognized as contributors to cognitive decline.
Why it matters
This review examines diet, physical activity, sleep, and social engagement as factors in preventing or delaying age-related cognitive decline and dementia, noting that results across studies have been mixed. It emphasizes prevention because no effective pharmaceutical therapies currently exist to treat age-associated cognitive impairment and dementia.
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An accurate COVID-19 mortality prediction model among hospitalized patients based on the clinical features and comorbidities may play a beneficial role in the clinical setting to better management of patients with COVID-19.
Why it matters
This study used machine learning to predict death in hospitalized COVID-19 patients, not Alzheimer's disease. It has no information about treating, curing or preventing Alzheimer's disease.
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This proof-of-concept study demonstrates that automated deep learning-driven processing of audio recordings of neuropsychological testing performed on individuals recruited within a community cohort setting can facilitate dementia screening.
Why it matters
In 1,264 audio recordings of memory-and-thinking test sessions from the Framingham Heart Study, two deep learning models were trained to tell recordings of people with dementia apart from those without it. The best model separated dementia from normal cognition with an AUC of 0.805 (balanced accuracy 0.743), but accuracy fell when people with mild cognitive impairment were counted in the non-dementia group (best AUC 0.746). The authors call it a proof-of-concept for automated screening from recordings averaging 73 minutes; it is not a validated diagnostic test and reports no treatment or prevention.
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55/100
The relationship between persistent loneliness and Alzheimer's disease (AD) is unclear.
Why it matters
This study examined whether different types of mid-life loneliness are associated with later development of dementia and Alzheimer's disease. It is observational and does not show that reducing loneliness prevents dementia.
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We found disparities between black and white residents with ADRD both within and across facilities.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Long-term exposure to fine particulate matter, residential proximity to major roads and measures of brain structure
- Alcohol consumption as a risk factor for dementia and cognitive decline: meta-analysis of prospective studies
- Explainable machine learning for predicting longitudinal dementia status: Establishing a leakage-free benchmark
- The protocols for the 10/66 dementia research group population-based research programme
- Telehealth Rehabilitation for Cognitive Impairment: Randomized Controlled Feasibility Trial
- Brain atrophy rates predict subsequent clinical conversion in normal elderly and amnestic MCI
- Assessment of the validity of the Resilience and Strain Questionnaire in Caregivers of People with Dementia (ResQ-Care-Dem): a cross-sectional survey study
- Mediterranean diet and cognitive function in older age
- Montreal Cognitive Assessment (MoCA) Scale: Strengths, Limitations, and Implication for Clinical Practice
- Twenty-year changes in dementia occurrence suggest decreasing incidence in central Stockholm, Sweden