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44/100

✓ Peer-reviewed alzhub usefulness score 44 out of 100. Long-term cohort studies

Topic: Risk, prevention and care in population studies

During a median follow-up of 13.8 years, 3,035 incident dementia cases were recorded, including 1,304 Alzheimer's disease (AD) cases and 597 vascular dementia (VD) cases. A higher adherence to a healthy sleep pattern was associated with a lower dementia risk. Each 1-point increase in the healthy sleep score corresponded to a 7% reduction in dementia risk (Hazard Ratio [HR] = 0.93, 95% Confidence Interval [CI]: 0.89-0.96). Compared to participants with a score of 0-1, those with a score of 5 had a significantly lower risk of dementia (HR = 0.75, 95% CI: 0.61-0.92). Benefits were more pronounced in adults aged 40-55 years than those aged 56-64 years (p for interaction < 0.001). Adherence to a healthy sleep pattern was associated with increased grey matter volume and decreased WMH volume (all p < 0.05). Mediation analysis indicates that preserving grey and white matter integrity partially mediated the dementia-risk-lowering benefit (p < 0.05). Adherence to a healthy sleep pattern is associated with both a reduced risk of dementia and greater white matter integrity, underscoring the role of improving overall sleep behaviors to support brain structure and lower dementia risk.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Wei, T., Chang, J., Zhao, Y., Li, A., Sun, W., Liu, X., et al. (2025). Associations of adherence to a healthy sleep pattern with the dementia risk in the UK biobank. Alzheimer s Research & Therapy. https://doi.org/10.1186/s13195-025-01864-x

Vancouver

Wei T, Chang J, Zhao Y, Li A, Sun W, Liu X, et al. Associations of adherence to a healthy sleep pattern with the dementia risk in the UK biobank. Alzheimer s Research & Therapy. 2025. doi:10.1186/s13195-025-01864-x. PMID: 41029423.

BibTeX

@article{wei2025-41029423,
  author  = {Wei, Tao and Chang, Jie and Zhao, Yiwei and Li, Aonan and Sun, Wei and Liu, Xiaoduo and Liu, Hongjia and Xing, Yi and others},
  title   = {{Associations of adherence to a healthy sleep pattern with the dementia risk in the UK biobank}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2025},
  doi     = {10.1186/s13195-025-01864-x},
  pmid    = {41029423},
  url     = {https://doi.org/10.1186/s13195-025-01864-x}
}

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Key findings

During a median follow-up of 13.8 years, 3,035 incident dementia cases were recorded, including 1,304 Alzheimer's disease (AD) cases and 597 vascular dementia (VD) cases.
A higher adherence to a healthy sleep pattern was associated with a lower dementia risk.
Each 1-point increase in the healthy sleep score corresponded to a 7% reduction in dementia risk (Hazard Ratio [HR] = 0.93, 95% Confidence Interval [CI]: 0.89-0.96).
Compared to participants with a score of 0-1, those with a score of 5 had a significantly lower risk of dementia (HR = 0.75, 95% CI: 0.61-0.92).
Benefits were more pronounced in adults aged 40-55 years than those aged 56-64 years (p for interaction < 0.001).

Why it matters

In this UK Biobank cohort, higher adherence to a healthy sleep pattern was linked to lower dementia risk, and this benefit was partly mediated by preserved grey and white matter integrity. The authors suggest improving overall sleep behaviours may support brain structure and lower dementia risk, but the study is observational.

Study details

Participants33,401
Effect sizeHR = 0.75
Evidence strengthLow

How this study scored 44/100

Published in a peer-reviewed journal. Scored zero for study design and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Alzheimer s Research & Therapy)
Journal's citation record	1 / 4	Alzheimer s Research & Therapy: journal h-index 146 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	4 / 4	33,401 participants
Effect reported	3 / 3	Effect reported with a statistic (interval, p-value, ratio or similar)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 2 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.7 citations a year over 3 year(s) since 2025
Impact for its field and year	2 / 6	Cited 1.3× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	1 / 6	Cited by 1 other studies in this library
Still being cited	0 / 4	Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Yi Tang: h-index 35 (OpenAlex, whole career)
Institution's track record	0 / 3	Capital Medical University: institution h-index 643 (OpenAlex)
Multicenter collaboration	1 / 3	OpenAlex lists 3 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41029423)
Free to read	2 / 2	Free to read
Total	44 / 100	—

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