Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Most people in Germany die in institutions; the most common place of death is still the hospital, where more than half of all deaths take place.
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Community-based services are important for improving outcomes for individuals with dementia and their caregivers.
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The consensus criteria for the diagnosis and classification of primary progressive aphasia (PPA) have served as an important tool in studying this group of disorders.
Why it matters
This study classified 130 patients with degenerative speech and language disorders into subtypes and found distinct patterns of brain loss, with logopenic aphasia strongly associated with being amyloid positive. It is about classifying these disorders, not about treating, curing, or preventing Alzheimer's disease.
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The original validation study for the Montreal Cognitive Assessment (MoCA) suggests a cutoff score of 26; however, this may be too stringent for older adults, particularly for those with less education.
Why it matters
This study produced age- and education-adjusted norms for the Montreal Cognitive Assessment in older adults aged 70 to 99. It is about interpreting a cognitive screening test, not about treating, curing or preventing Alzheimer's disease.
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Small vessel disease encompasses lacunar stroke, white matter hyperintensities, lacunes and microbleeds.
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A number of studies have linked neuropsychiatric symptoms to increase risk of dementia.
Why it matters
Among 4,517 cognitively normal volunteers aged 60 and older, this study examined whether different patterns of neuropsychiatric symptoms were linked to conversion to mild cognitive impairment or dementia. The researchers used data from 34 Alzheimer Disease Centers to see if symptom patterns in healthy controls predicted later decline.
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Residents and relatives experience ethical challenges in Norwegian nursing homes, mostly connected to "everyday ethical issues."
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Increased peripheral and central nervous system cortisol levels have been reported in Alzheimer's disease (AD) and may reflect dysfunction of cerebral components of the hypothalamic-pituitary-adrenal (HPA) axis.
Why it matters
Cerebrospinal fluid cortisol was higher in people with Alzheimer's dementia or MCI of Alzheimer's type than in other groups, and higher baseline levels were associated with faster clinical worsening in MCI of Alzheimer's type. This is an observational study of a marker and does not show that lowering cortisol treats, cures, or prevents the disease.
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A large proportion of patients with ECI decline ACP discussions and the reasons are influenced by personal values, coping behaviours and sociocultural norms.
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Cognition clinic and memory clinic of a public hospital in Hong Kong.
Why it matters
This cross-sectional study validated the Hong Kong version of the Montreal Cognitive Assessment in 272 Chinese older adults with dementia, mild cognitive impairment, or normal cognition. It is a test-validation study and does not test any treatment, cure, or prevention.
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Post-stroke cognitive impairment occurs frequently in the patients with stroke.
Why it matters
This review describes that post-stroke cognitive impairment is common and that its mechanisms are not known in detail, though stroke lesions, white matter lesions, microbleeds, and mixed Alzheimer's disease with stroke may contribute. It discusses possible management strategies but does not test any treatment or prevention.
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There were no overall differences between patients with breast cancer and controls before systemic treatment, but there may be pretreatment cognitive impairment within subgroups of patient cases with greater tumor or comorbidity burden.
Why it matters
This study found that older patients with breast cancer had similar neuropsychological domain scores to controls before systemic therapy. However, among patients, those with more advanced cancer had lower executive function, and greater comorbidity was associated with higher odds of impairment.
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47/100
We studied whether anxiety symptoms and anxiety disorders are associated with the risk of dementia and cognition.
Why it matters
In this large population study, anxiety symptoms and anxiety disorders were not associated with the risk of dementia or cognitive decline. This means anxiety does not appear to be a risk factor for dementia in this group, though it does not rule out other reasons to treat anxiety.
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The percentage of psychological distress was similar between caregivers of cancer patients (77.6%) and caregivers of dementia patients (72.4%).
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47/100
The median age of participants was 79 years, 69% (31 of 45) were of non-Hispanic white race/ethnicity, and 60% (27 of 45) had attended at least some college.
Why it matters
This study developed and evaluated a decision aid about mammography screening for women 75 and older. It concerns breast cancer screening decisions and did not study the treatment, cure or prevention of Alzheimer's disease.
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47/100
Whether depression is a long-term risk factor for dementia or represents a dementia prodrome is unclear.
Why it matters
In 4,393 nondemented Rotterdam Study participants followed for 13.7 years, depressive symptoms predicted incident dementia during short but not long follow-up. This suggests depression may sometimes be an early sign of dementia rather than a long-term cause, and it does not test any treatment, cure, or prevention.
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Diffuse axonal injury after traumatic brain injury (TBI) produces neurological impairment by disconnecting brain networks.
Why it matters
This review describes how traumatic brain injury disrupts large-scale brain networks and discusses how such damage might interact with inflammation and neurodegeneration in the later development of Alzheimer's disease. It is a review of mechanisms and reports no treatment that cures or prevents Alzheimer's disease.
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The results of our study contribute to a better understanding of the factors hindering GPs in initiating ACP.
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Parkinson's Disease is the second most common progressive neurodegenerative disorder affecting older American adults and is predicted to increase in prevalence as the United States population ages.
Why it matters
This review states that Parkinson's disease can be associated with cognitive impairment and dementia, and that no definitive disease-modifying therapy exists, with experimental therapies showing limited results. It provides background on Parkinson's disease rather than testing any treatment, prevention, or cure for Alzheimer's disease.
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In an aging population with increasing incidence of dementia and cognitive impairment, strategies are needed to slow age-related decline and reduce disease-related cognitive impairment in older adults.
Why it matters
This review reports that observational studies support a dose-dependent neuroprotective relationship between physical exercise and cognitive performance in older adults. It notes that while some clinical trials of exercise interventions show positive effects on cognitive performance, others show minimal to no effect.
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Higher levels of accordance with both the DASH and Mediterranean dietary patterns were associated with consistently higher levels of cognitive function in elderly men and women over an 11-y period.
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Older adults in China have high levels of undetected dementia and depression.
Why it matters
This study found that most dementia and depression in older adults in China went undetected. It identified low education, low occupation, and rural living as factors linked to undetected dementia, but it does not test any treatment or cure.
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47/100
Given the reported health benefits of a Mediterranean diet (MedDiet) and delay in cognitive decline, we aimed to determine the level of adherence to a MedDiet using an 11-point scale and examine relationships with cognitive function and psychological well-being.
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This qualitative evaluation of ACP in early dementia has encouragingly positive results which support the wider application of the intervention in memory services and community mental health teams.
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Cognitive and depressive disorders are common in elderly Chinese and are becoming an increasingly important public health problem, partly because of the rapid aging of the population.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- The influence of education, social class and sex on Mini-Mental State scores
- Diabetes and its complications: molecular mechanisms, prevention and treatment
- Prediabetes and risk of mortality, diabetes-related complications and comorbidities: umbrella review of meta-analyses of prospective studies
- An update on genetic frontotemporal dementia
- Diabetes mellitus and risk of dementia: A meta-analysis of prospective observational studies
- Associations between low-dose drinking water lithium exposure and Dementia: A nationwide U.S. ecological study
- Subscale validation of the neuropsychiatric inventory questionnaire: comparison of Alzheimer's disease neuroimaging initiative and national Alzheimer's coordinating center cohorts
- A nonparametric method for automatic correction of intensity nonuniformity in MRI data
- Late-Life Body Mass Index, Rapid Weight Loss, Apolipoprotein E ε4 and the Risk of Cognitive Decline and Incident Dementia
- Quality of life in nursing home residents with advanced dementia