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Cardiometabolic disorders and mild cognitive impairment in White and Black Americans
Voyko Kavcic, Mohammad Turaani, Subhamoy Pal, Jonathan M. Reader, Bruno Giordani. Alzheimer s & Dementia, 2025-09-01
Topic: Risk, prevention and care in population studies
Controlling for demographic/health variables, individuals with aMCI, though not naMCI, showed a higher likelihood of hypertension, diabetes, and hyperlipidemia compared to cognitively normal counterparts, though no differences between aMCI/naMCI. Black Americans, regardless of cognitive status, were more likely to fall into hypertension and diabetes groups compared to White Americans. These findings underscore the critical role of diagnosis and race in MCI diagnosis and care, emphasizing the need for tailored interventions to address inequities and reduce the risk of progression to dementia. HIGHLIGHTS: The study leverages a large, racially diverse cohort from the NACC database. Black Americans with non-amnestic mild cognitive impairment(naMCI) show highest comorbidity burden. No significant differences in comorbidity burden between amnestic MCI (aMCI) and naMCI subtypes. Education is protective, but less so for Black American individuals. Older age, male sex, body mass index (BMI), and low education associate with increased risk for comorbidities.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Kavcic, V., Turaani, M., Pal, S., Reader, J. M., & Giordani, B. (2025). Cardiometabolic disorders and mild cognitive impairment in White and Black Americans. Alzheimer s & Dementia. https://doi.org/10.1002/alz.70642
Vancouver
Kavcic V, Turaani M, Pal S, Reader JM, Giordani B. Cardiometabolic disorders and mild cognitive impairment in White and Black Americans. Alzheimer s & Dementia. 2025. doi:10.1002/alz.70642. PMID: 40926187.
BibTeX
@article{kavcic2025-40926187,
author = {Kavcic, Voyko and Turaani, Mohammad and Pal, Subhamoy and Reader, Jonathan M. and Giordani, Bruno},
title = {{Cardiometabolic disorders and mild cognitive impairment in White and Black Americans}},
journal = {Alzheimer s \& Dementia},
year = {2025},
doi = {10.1002/alz.70642},
pmid = {40926187},
url = {https://doi.org/10.1002/alz.70642}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Controlling for demographic/health variables, individuals with aMCI, though not naMCI, showed a higher likelihood of hypertension, diabetes, and hyperlipidemia compared to cognitively normal counterparts, though no differences between aMCI/naMCI.
- Black Americans, regardless of cognitive status, were more likely to fall into hypertension and diabetes groups compared to White Americans.
- These findings underscore the critical role of diagnosis and race in MCI diagnosis and care, emphasizing the need for tailored interventions to address inequities and reduce the risk of progression to dementia.
- HIGHLIGHTS: The study leverages a large, racially diverse cohort from the NACC database.
- Black Americans with non-amnestic mild cognitive impairment(naMCI) show highest comorbidity burden.
Why it matters
People with amnestic mild cognitive impairment were more likely to have hypertension, diabetes and hyperlipidemia than cognitively normal counterparts, and Black Americans were more likely to fall into hypertension and diabetes groups regardless of cognitive status. The authors say this underscores the need for tailored interventions to address inequities and reduce the risk of progression to dementia.
Study details
- Participants8,737
- Evidence strengthModerate
How this study scored 44/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 3 / 4 | 8,737 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 1 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 1 / 6 | Cited 0.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Bruno Giordani: h-index 76 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Michigan: institution h-index 2,240 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40926187) |
| Free to read | 2 / 2 | Free to read |
| Total | 44 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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