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Age- and sex-specific modifiable risk factor profiles of dementia: evidence from the UK Biobank
Chen H, Cao Y, Ma Y, Xu W, Zong G, Yuan C.. European journal of epidemiology, 2023-01-03
Topic: Risk, prevention and care in population studies
Dementia constitutes a worldwide concern. To characterize the age- and sex-specific modifiable risk factor profiles of dementia, we included 497,401 UK Biobank participants (mean age = 56.5 years) without dementia at baseline (2006-2010) and followed them until March 2021. Cox proportional hazard models were used to estimate the age- and sex-specific hazard ratios (HRs) of incident dementia associated with socioeconomic (less education and high Townsend deprivation index), lifestyle (non-moderate alcohol intake, current smoking, suboptimal diet, physical inactivity, and unhealthy sleep duration), and health condition factors (hypertension, diabetes, cardiovascular diseases, and depressive symptoms).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Chen, H., Cao, Y., Ma, Y., Xu, W., Zong, G., & Yuan, C. (2023). Age- and sex-specific modifiable risk factor profiles of dementia: evidence from the UK Biobank. European journal of epidemiology. https://doi.org/10.1007/s10654-022-00952-8
Vancouver
Chen H, Cao Y, Ma Y, Xu W, Zong G, Yuan C. Age- and sex-specific modifiable risk factor profiles of dementia: evidence from the UK Biobank. European journal of epidemiology. 2023. doi:10.1007/s10654-022-00952-8. PMID: 36593335.
BibTeX
@article{chen2023-36593335,
author = {Chen, H. and Cao, Y. and Ma, Y. and Xu, W. and Zong, G. and Yuan, C.},
title = {{Age- and sex-specific modifiable risk factor profiles of dementia: evidence from the UK Biobank}},
journal = {European journal of epidemiology},
year = {2023},
doi = {10.1007/s10654-022-00952-8},
pmid = {36593335},
url = {https://doi.org/10.1007/s10654-022-00952-8}
}
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Key findings
- To characterize the age- and sex-specific modifiable risk factor profiles of dementia, we included 497,401 UK Biobank participants (mean age = 56.5 years) without dementia at baseline (2006-2010) and followed them until March 2021.
- Cox proportional hazard models were used to estimate the age- and sex-specific hazard ratios (HRs) of incident dementia associated with socioeconomic (less education and high Townsend deprivation index), lifestyle (non-moderate alcohol intake, current smoking, suboptimal diet, physical inactivity, and unhealthy sleep duration), and health condition factors (hypertension, diabetes, cardiovascular diseases, and depressive symptoms).
- We also calculated the population attributable fractions (PAFs) of these factors.
- During follow-up (mean = 11.6 years), we identified 6564 dementia cases.
Why it matters
This study characterized age- and sex-specific modifiable risk factor profiles for dementia in UK Biobank participants. It examined socioeconomic, lifestyle, and health condition factors in relation to incident dementia.
Study details
- Participants497,401
- Effect size46.8%; 37.4%; 55.2%
- Evidence strengthLow
How this study scored 55/100
Published in a peer-reviewed journal. Scored zero for study design and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (European journal of epidemiology) |
| Journal's citation record | 2 / 4 | European Journal of Epidemiology: journal h-index 175 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 4 / 4 | 497,401 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 42 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 8.4 citations a year over 5 year(s) since 2023 |
| Impact for its field and year | 3 / 6 | Cited 7.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 6 other studies in this library |
| Still being cited | 2 / 4 | Cited 40 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Changzheng Yuan: h-index 41 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 8 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 36593335) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 55 / 100 | — |
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