Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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55/100
Individuals with dementia and their care partners often report dissatisfaction with the disclosure process due to insufficient information and support.
Why it matters
This rapid review found that many individuals are dissatisfied with the dementia diagnosis disclosure process and that healthcare providers face challenges in communication. It addresses improving disclosure practices, not treating, curing, or preventing Alzheimer's disease.
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From an initial cohort of 18 605 participants, 10 058 were included (5062 men [50.3%]; 4996 women [49.7%]; mean [SD] age, 60.9 [7.2] years).
Why it matters
This cohort study found that nonintensive grandchild caregiving was associated with lower odds of dementia compared with no grandchild care, partly mediated by mobile telephone ownership, broadband internet access, and reduced loneliness. Neither intensive grandchild caregiving nor having no grandchildren was associated with dementia odds.
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In this cross-sectional study examining generational differences in age-specific dementia prevalence across the US, Europe, and England, we found that individuals from more recent birth cohorts had lower proportions of people with dementia.
Why it matters
Looking at data from the US, Europe, and England, this study found that people born in more recent years had lower proportions of dementia at a given age. The downward trend was more pronounced among women than men, and for men in England the estimates were not statistically significant.
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55/100
There was a significantly higher risk of developing a dementia diagnosis in Hispanic/Latino and NHB participants than NHW participants and comparably increased dementia hazard ratios in the Hispanic/Latino, NHB, and NHW APOE4 carriers than non-carriers (hazard ratio [HR] [95% confidence interval {CI}] 1.54 [1.25-1.91], 1.25 [1.00-1.57], and 1.55 [1.40-1.72]).
Why it matters
This study found that Hispanic/Latino and non-Hispanic Black individuals had a higher risk of developing a dementia diagnosis, and the impact of APOE4 on dementia risk was similar across the studied ethnoracial groups. It addresses risk factors and disparities, not treating, curing, or preventing the disease.
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Vaccination is increasingly acknowledged as an effective preventive measure not only against specific infections, but also for the prevention of cardiovascular disease in high-risk patients.
Why it matters
This consensus statement is about vaccination as cardiovascular prevention, not Alzheimer's disease, so it provides no information on Alzheimer's treatment, cure or prevention. It notes evidence that influenza vaccination reduces major adverse cardiovascular events in vaccinated individuals.
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DAGs provide visual representations of assumptions made, and provide an objective approach to appropriate statistical adjustments.
Why it matters
This methodological paper describes how directed acyclic graphs were used in the SNAP-3 observational cohort study of frailty, multimorbidity, and delirium in older surgical patients. It provides a framework for statistical decision-making but reports no treatment, cure, or prevention for Alzheimer's disease.
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A total of 1869 participants contributed 5309 observations (mean age 82.9 years, 21.0% Black, 9.3% met research-based dementia criteria).
Why it matters
ICD-10 Medicare claims identified dementia with 87% to 90% accuracy but were less accurate in older, minoritized, depressed, or stroke-affected subgroups. This is about how dementia is counted in research, not about treating, curing, or preventing it.
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It remains a common yet underrecognised complication in older surgical patients, significantly influencing recovery, prolonging hospital stays and increasing healthcare costs and workload.1 Although traditionally peri-operative care has prioritised physical stabilisation, effectively addressing POD requires a holistic approach that also considers patients’ emotional and social well being.2 One well established strategy for managing delirium is the active involvement of family and caregivers.
Why it matters
This systematic review reports that the presence of chosen family or caregivers during the peri-operative period has significant potential to mitigate the incidence and severity of delirium in geriatric patients. It does not report any treatment or cure for Alzheimer's disease.
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At least 45% of dementia and 60% of stroke cases are due to modifiable risk factors and could in part be prevented through healthy behavior.
Why it matters
In a U.S. cohort, people clustered into groups based on their knowledge and practice of healthy behaviors for dementia and stroke prevention. Those with high knowledge and good practice were older, more educated, and perceived fewer barriers, which could help tailor prevention strategies.
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Up-to-date, strictly cross-nationally comparable and nationally representative data on cognitive health are essential for our understanding of the dementia-related challenges in healthcare, to detect shortcomings in healthcare systems and to design effective prevention strategies.
Why it matters
This study found large variation in dementia and mild cognitive impairment prevalence across Europe and Israel, much of which was explained by differences in education when respondents were young. It concerns prevalence estimates and possible prevention strategies, and reports no treatment or cure.
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There were 656 deaths, 1585 incidents of CVD and 165 dementia diagnoses during 17.2 years of follow-up.
Why it matters
In this longitudinal study of Australian women, better diet quality was linked to lower all-cause mortality, but there were no associations between diet indices and dementia outcomes. It does not show that diet quality prevents dementia.
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This disease is associated with numerous restrictions for those affected but also for caregivers and society.
Why it matters
This is a protocol for a randomized controlled trial to evaluate a Chinese version of the non-pharmacological, multimodal MAKS intervention for people with mild to moderate dementia in Chinese nursing homes. No results are reported yet, so it provides no evidence about treating, curing, or preventing Alzheimer's disease.
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Prevention of dementia represents a public health priority.
Why it matters
In 180 hypertensive patients, subclinical left ventricular dysfunction measured by global longitudinal strain was significantly associated with mild cognitive impairment. This is an observational association and does not test any treatment, cure or prevention.
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The incidence of dementia was 0.68 (95% CI 0.64-0.72) cases per 100 person-years in pSS, and it was 0.58 (0.56-0.60) in the controls.
Why it matters
People with primary Sjögren's syndrome had a higher risk of developing dementia than controls, and those taking hydroxychloroquine had a lower risk than non-users. The authors suggest hydroxychloroquine may prevent dementia in these patients, but this was an observational cohort study and not a trial.
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CMS was likely cost-effective from the payer but not from a societal perspective, underlining the importance of informal care.
Why it matters
In this cluster-randomized controlled trial of 192 caregivers, the digitally supported care management group gained QALYs (+0.004) and had lower public payer costs (-378€) but higher societal costs (+1324€), with the intervention dominating usual care from the payer perspective. The probability of cost-effectiveness was 72% and 79% from the public payer and 33% and 35% from a societal perspective at the willingness-to-pay thresholds, so this concerns caregiver support rather than curing or preventing Alzheimer's disease.
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NPS was longitudinally associated with performance in each cognitive domain.
Why it matters
Neuropsychiatric symptoms were longitudinally associated with performance in each cognitive domain, while amyloid was associated with cognition only at baseline and not with neuropsychiatric symptoms. This supports including neuropsychiatric symptom changes in early detection models, but it does not test any treatment, cure or prevention.
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55/100
Chronological age is an imperfect estimate of molecular aging.
Why it matters
In 4,018 participants, having a prior stroke, dementia, or late-life depression was linked to being epigenetically older, and greater epigenetic age predicted higher odds of a brain health event in the next four years. The authors suggest epigenetic age could be used as a biomarker to evaluate interventions aimed at preventing these conditions and promoting recovery.
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Of 2,218 participants, 237 (11%) developed dementia in the period 1992/3 to 2015/6.
Why it matters
This cohort study found that sleeping six hours or less, interrupted sleep, and waking up early were associated with incident dementia, particularly with longer lag times of 15 years or more. The association between sleeping nine hours or more and dementia at a short lag time appeared to be the result of reverse causation.
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Age, education level, number of pain sites, pain duration, pain level, depression and sleep quality were risk factors of MCI in older patients with chronic pain.
Why it matters
Nine machine learning models were developed to identify risk of mild cognitive impairment in older patients with chronic pain, with the XGBoost model performing best and pain level, age, and depression as the most important variables. The authors note these findings need validation with longitudinal data, and this is a risk-detection tool, not a treatment, cure, or prevention.
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Participants with more FTUs were found to have a slower biological ageing process.
Why it matters
This study is about chewing capacity, diet, ageing and mortality risk and contains no information on Alzheimer's disease. It reports no findings relevant to treating, curing or preventing dementia.
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After 3.5 years of follow up, 19 new cases of dementia were identified among 229 surviving participants.
Why it matters
This cohort study provides the first dementia incidence estimates from the Middle East and North Africa region, with rates close to European and North American estimates. The authors call for a larger cohort study to confirm these results.
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The study sample included 3566 Black (16 104 observations) and 17 555 White (90 874 observations) participants.
Why it matters
This study found that Black older adults who attended highly segregated schools in childhood had lower cognitive scores and higher rates of cognitive impairment and dementia later in life, while no such link was seen in White participants. Because the study looked at one point in time, it cannot prove that school segregation caused these later cognitive problems.
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This cohort study evaluates the prevalence of dementia diagnoses among US adults with autism spectrum disorder.
Why it matters
This cohort study evaluates the prevalence of dementia diagnoses among US adults with autism spectrum disorder. No results or conclusions are provided in the available text.
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= 0.279). No adverse events were reported.
Why it matters
This study found that live online exercise sessions for older adults with mild cognitive impairment were safe and feasible, with adherence and intensity comparable to onsite sessions. It addresses how to deliver exercise, not whether exercise treats, cures or prevents Alzheimer's disease.
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Higher ADI was significantly associated with lower MMSE score.
Why it matters
In this study, people living in more disadvantaged neighborhoods scored lower on a memory-and-thinking screening test (MMSE), yet did not have more dementia-related brain changes, and the link held after accounting for those changes. The link was weaker in people with more years of education. The authors read this as neighborhood disadvantage being associated with lower cognitive reserve; it shows an association, not that neighborhood causes dementia.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Long-term exposure to traffic-related particulate matter impairs cognitive function in the elderly
- The value of the Rivermead Behavioural Memory Test (Children's Version) in an epidemiological study of older adults with Down syndrome
- Biomarcadores para diagnóstico e prognóstico de doenças neurodegenerativas: uma revisão de literatura
- Characteristics of dementia end-of-life care across care settings
- ACONAMI : A Case for Asian Mental Health Transformation
- Hypoglycaemia in diabetes mellitus: epidemiology and clinical implications
- Medication Causes and Treatment of Delirium in Patients With and Without Dementia
- Substitutions of Sleep, Physical Activity, and Sedentary Behaviour and the Risk of Dementia and Stroke
- Quantitative EEG (QEEG) Measures Differentiate Parkinson's Disease (PD) Patients from Healthy Controls (HC)
- Real-world safety profile of lecanemab: A disproportionality analysis of adverse events in the FDA adverse event reporting system