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Resting-state fMRI in Parkinson's disease patients with cognitive impairment: A meta-analysis
Amée F Wolters, Sjors C F van de Weijer, Albert F G Leentjens, Annelien A Duits, Heidi I L Jacobs, Mark L Kuijf. Parkinsonism & related disorders, 2018-12-17
Topic: Brain imaging, connectivity and assessment
Seventeen studies with cognitively impaired Parkinson's disease patients were included consisting of 222 Parkinson's disease patients with mild cognitive impairment, 68 patients with Parkinson's disease dementia, 289 cognitively unimpaired Parkinson's disease patients and 353 healthy controls. Parkinson's disease patients with cognitive impairment predominantly showed a reduced connectivity in specific brain regions that are part of the default mode network. Cognitive impairment in Parkinson's disease is associated with reduced connectivity in networks relevant to cognition, most prominently the default mode network. Specific alterations in functional connectivity may contribute to cognitive decline in Parkinson patients and may be a promising future biomarker.
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APA 7th
Wolters, A. F., van de Weijer, S. C. F., Leentjens, A. F. G., Duits, A. A., Jacobs, H. I. L., & Kuijf, M. L. (2019). Resting-state fMRI in Parkinson's disease patients with cognitive impairment: A meta-analysis. Parkinsonism & related disorders. https://doi.org/10.1016/j.parkreldis.2018.12.016
Vancouver
Wolters AF, van de Weijer SCF, Leentjens AFG, Duits AA, Jacobs HIL, Kuijf ML. Resting-state fMRI in Parkinson's disease patients with cognitive impairment: A meta-analysis. Parkinsonism & related disorders. 2019. doi:10.1016/j.parkreldis.2018.12.016. PMID: 30580907.
BibTeX
@article{wolters2019-30580907,
author = {Wolters, Amée F and van de Weijer, Sjors C F and Leentjens, Albert F G and Duits, Annelien A and Jacobs, Heidi I L and Kuijf, Mark L},
title = {{Resting-state fMRI in Parkinson's disease patients with cognitive impairment: A meta-analysis}},
journal = {Parkinsonism \& related disorders},
year = {2019},
doi = {10.1016/j.parkreldis.2018.12.016},
pmid = {30580907},
url = {https://doi.org/10.1016/j.parkreldis.2018.12.016}
}
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Key findings
- Seventeen studies with cognitively impaired Parkinson's disease patients were included consisting of 222 Parkinson's disease patients with mild cognitive impairment, 68 patients with Parkinson's disease dementia, 289 cognitively unimpaired Parkinson's disease patients and 353 healthy controls.
- Parkinson's disease patients with cognitive impairment predominantly showed a reduced connectivity in specific brain regions that are part of the default mode network.
- Cognitive impairment in Parkinson's disease is associated with reduced connectivity in networks relevant to cognition, most prominently the default mode network.
- Specific alterations in functional connectivity may contribute to cognitive decline in Parkinson patients and may be a promising future biomarker.
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Study details
- Study designmeta-analysis
- Participants68
- Evidence strengthHigh
How this study scored 75/100
Published in a peer-reviewed journal, and it is a meta-analysis pooling many studies. Scored zero for effect reported because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 42 of the 56 points we could judge it on, which is 75 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Parkinsonism & related disorders) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 12 / 12 | A meta-analysis pooling many studies |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 1 / 4 | 68 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | A review of other studies — randomization is not credited here |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 30580907) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 42 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 42 of the 56 points we could judge it on is 75 out of 100. |
| Total | 75 / 100 | — |
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