Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 24,726–24,750 of 27,380 studies, newest first · page 990 of 1096.
October 2002 16
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2002-10-01
Systematic detection and multidisciplinary care of delirium in older medical inpatients: a randomized trial
54/100 ✓ Peer-reviewed Cognitive tests and assessment CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
Key finding: Delirium is common and often goes undetected in older patients admitted to medical services. +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-10-01
Early and widespread cholinergic losses differentiate dementia with Lewy bodies from Alzheimer disease
47/100 ✓ Peer-reviewed Cognitive tests and assessment Archives of general psychiatry
Key finding: Reductions in cholinergic function occur in Alzheimer disease (AD) and dementia with Lewy bodies and correlate with cognitive decline. +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-10-01
Brief screening tests for dementia
44/100 ✓ Peer-reviewed Cognitive tests and assessment Canadian journal of psychiatry. Revue canadienne de psychiatrie
Key finding: We selected screening tests that met 2 criteria: 1) administration time of 10 minutes or less in studies including individuals with, and without, dementia; and 2) performance characteristics evaluated in at least 1 community or clinical sample of older adults. +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-10-01
Impairment of cholinergic neurotransmission in adult and aged transgenic Tg2576 mouse brain expressing the Swedish mutation of human beta-amyloid precursor protein
40/100 ✓ Peer-reviewed Risk genes beyond APOE Brain research
Key finding: Cortical and hippocampal activities of AChE and ChAT were not different between transgenic mice and non-transgenic littermates regardless of the postnatal ages examined. +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-10-01
Alzheimer's disease can be accurately diagnosed in very mildly impaired individuals
48/100 ✓ Peer-reviewed Mild cognitive impairment Neurology
Key finding: When comprehensive assessment procedures are employed, AD can be diagnosed with reasonably high accuracy in very mildly impaired individuals. +1 more finding
Full summary, score breakdown and related studies → Original source
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2002-10-01
Rates of progression in mild cognitive impairment and early Alzheimer's disease
61/100 ✓ Peer-reviewed Mild cognitive impairment Neurology
Key finding: The lack of effective predictors of the rate of dementia progression extends to the very earliest stages of the disease, including what is often called MCI.
Full summary, score breakdown and related studies → Original source
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2002-10-01
Tau conformational changes correspond to impairments of episodic memory in mild cognitive impairment and Alzheimer's disease
41/100 ✓ Peer-reviewed Mild cognitive impairment Experimental neurology
Key finding: These analyses revealed three main findings. +2 more findings
Full summary, score breakdown and related studies → Original source
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2002-10-01
Relative frequencies of Alzheimer disease, Lewy body, vascular and frontotemporal dementia, and hippocampal sclerosis in the State of Florida Brain Bank
54/100 ✓ Peer-reviewed Lewy body dementia Alzheimer disease and associated disorders
Key finding: AD was the most frequent pathologic finding (77%), followed by LBD (26%), VaD (18%), HS (13%), and FTD (5%). +4 more findings
Full summary, score breakdown and related studies → Original source
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2002-10-01
Frontotemporal dementia: patient characteristics, cognition, and behaviour
43/100 ✓ Peer-reviewed Digital health tools International journal of geriatric psychiatry
Key finding: The average age at onset of first symptoms was 57.8 years. +2 more findings
Full summary, score breakdown and related studies → Original source
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2002-10-01
Delirium superimposed on dementia: a systematic review
65/100 ✓ Peer-reviewed How common it is Journal of the American Geriatrics Society
Key finding: To date, only one reported study systematically identified associated factors and interventions for delirium superimposed on dementia, but several studies examining outcomes have found that adverse events are associated with delirium in persons with dementia, including accelerated and long-term cognitive and functional decline, need for institutionalization, rehospitalization, and increased mortality.
Full summary, score breakdown and related studies → Original source
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2002-10-01
Rural families caring for a relative with dementia: barriers to use of formal services
40/100 ✓ Peer-reviewed Disparities Social science & medicine (1982)
Key finding: Planning for the care of increasing numbers of elderly persons with dementia has become an urgent health services concern in Canada and elsewhere, yet little is known about the challenges of providing appropriate dementia care in rural areas. +4 more findings
Full summary, score breakdown and related studies → Original source
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2002-10-01
Dementia caregiver intervention research: in search of clinical significance
46/100 ✓ Peer-reviewed Caregiving The Gerontologist
Key finding: Although many studies have reported small to moderate statistically significant effects on a broad range of outcomes, only a small proportion of these studies achieved clinically meaningful outcomes.
Full summary, score breakdown and related studies → Original source
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2002-10-01
Changes in appetite, food preference, and eating habits in frontotemporal dementia and Alzheimer's disease
52/100 ✓ Peer-reviewed Caregiving Journal of neurology, neurosurgery, and psychiatry
Key finding: Change in eating behaviour was significantly more common in both of the frontotemporal dementia groups than in Alzheimer's disease. +1 more finding
Full summary, score breakdown and related studies → Original source
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2002-10-01
The overlap of amyotrophic lateral sclerosis and frontotemporal dementia
59/100 ✓ Peer-reviewed Getting a diagnosis Neurology
Key finding: An additional five patients had prominent fasciculations and six other patients had trouble swallowing but all had normal results on EMG studies.
Full summary, score breakdown and related studies → Original source
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2002-10-01
The prevention of dementia with antihypertensive treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study
75/100 ✓ Peer-reviewed Treatments Archives of internal medicine
Key finding: Median follow-up increased from 2.0 years in the double-blind trial to 3.9 years overall. +1 more finding
Full summary, score breakdown and related studies → Original source
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2002-10-01
Apolipoprotein E, amyloid, and Alzheimer disease
38/100 ✓ Peer-reviewed Genetics Molecular interventions
Key finding: Despite important inroads into the molecular pathology of Alzheimer disease, effective long-term treatment for the condition remains elusive. +2 more findings
Full summary, score breakdown and related studies → Original source
September 2002 9
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2002-09-20
Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling
36/100 ✓ Peer-reviewed Disease mechanisms Proceedings of the National Academy of Sciences of the United States of America
Key finding: These observations suggest that Alphabeta acts directly on the pathways involved in the formation of late LTP and agents that enhance the cAMP/PKA/CREB-signaling pathway have potential for the treatment of AD.
Full summary, score breakdown and related studies → Original source
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2002-09-16
Deaths: leading causes for 2000
36/100 ✓ Peer-reviewed Disparities PubMed
Key finding: In 2000 the 10 leading causes of death were (in rank order) Diseases of heart; Malignant neoplasms; Cerebrovascular diseases; Chronic lower respiratory diseases; Accidents (unintentional injuries); Diabetes mellitus; Influenza and pneumonia; Alzheimer's disease; Nephritis, nephrotic syndrome and nephrosis; and Septicemia and accounted for nearly 80 percent of all deaths occurring in the United States. +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-09-13
The central nervous system as a reservoir for simian immunodeficiency virus (SIV): steady-state levels of SIV DNA in brain from acute through asymptomatic infection
36/100 ✓ Peer-reviewed Inflammation and the immune system The Journal of infectious diseases
Key finding: Latent reservoirs of human immunodeficiency virus (HIV) present significant challenges for eradicating HIV from infected persons, particularly reservoirs in the brain established during acute infection. +2 more findings
Full summary, score breakdown and related studies → Original source
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2002-09-01
The accuracy of medicare claims data in identifying Alzheimer's disease
45/100 ✓ Peer-reviewed Costs and economics Journal of clinical epidemiology
Key finding: The data indicate that at least 3 consecutive years of physician supplier and physician outpatient claim files should be used to identify Medicare beneficiaries with AD using Medicare claims.
Full summary, score breakdown and related studies → Original source
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2002-09-01
Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial
76/100 ✓ Peer-reviewed Drug development Annals of neurology
Key finding: Overall, simvastatin did not significantly alter cerebrospinal fluid levels of Abeta40 and Abeta42. +1 more finding
Full summary, score breakdown and related studies → Original source
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2002-09-01
Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4
36/100 ✓ Peer-reviewed Drug development The Journal of pharmacology and experimental therapeutics
Key finding: These findings identify a novel neuroprotective/neurotrophic function of GLP-1 and suggest that such peptides may have potential for halting or reversing neurodegenerative processes in CNS disorders, such as Alzheimer's disease, and in neuropathies associated with type 2 diabetes mellitus.
Full summary, score breakdown and related studies → Original source
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2002-09-01
A role for local inflammation in the formation of drusen in the aging eye
36/100 ✓ Peer-reviewed Brain scans and imaging American journal of ophthalmology
Key finding: The results support a role for local inflammation in drusen biogenesis, and suggest that it is analogous to the process that occurs in other age-related diseases, such as Alzheimer's disease and atherosclerosis, where accumulation of extracellular plaques and deposits elicits a local chronic inflammatory response that exacerbates the effects of primary pathogenic stimuli. +2 more findings
Full summary, score breakdown and related studies → Original source
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2002-09-01
Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase-related protein 2, alpha-enolase and heat shock cognate 71
36/100 ✓ Peer-reviewed Genetics Journal of neurochemistry
Key finding: In particular, it has been shown that protein modification by reactive oxygen species (ROS) occurs to a greater extent in AD than in control brain, suggesting a possible role for oxidation-related decrease in protein function in the process of neurodegeneration. +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-09-01
Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death
36/100 ✓ Peer-reviewed Genetics Neurobiology of aging
Key finding: Abeta(1-42) addition to synaptosomes also results in HNE binding to Glt-1, thereby coupling increased Abeta(1-42) in AD brain to increased lipid peroxidation and its sequelae and possibly explaining the mechanism of glutamate transport inhibition known in AD brain. +3 more findings
Full summary, score breakdown and related studies → Original source
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