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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 24,601–24,625 of 27,380 studies, newest first · page 985 of 1096.

January 2003 25

  1. 2003-01-24

    Course of illness, hippocampal function, and hippocampal volume in major depression

    ✓ Peer-reviewed Hippocampus size on brain scans Proceedings of the National Academy of Sciences of the United States of America

    Key finding: Twenty never-treated depressed subjects in a first episode of depression were compared with matched healthy control subjects. +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2003-01-24

    Intracellular human immunodeficiency virus Tat expression in astrocytes promotes astrocyte survival but induces potent neurotoxicity at distant sites via axonal transport

    ✓ Peer-reviewed Inflammation and the immune system The Journal of biological chemistry

    Key finding: Astrocyte infection with HIV has been associated with rapid progression of dementia. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2003-01-06

    Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

    ✓ Peer-reviewed Risk genes beyond APOE The Journal of cell biology

    Key finding: APP is cleaved either by beta-secretase or by alpha-secretase to initiate amyloidogenic (release of A beta) or nonamyloidogenic processing of APP, respectively. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2003-01-01

    Vascular Factors and Risk of Dementia: Design of the Three-City Study and Baseline Characteristics of the Study Population

    ✓ Peer-reviewed Risk factors Neuroepidemiology

    Key finding: After exclusion of the participants who had subsequently refused the medical interview, the 3C Study sample consisted of 3,649 men (39.3%) and 5,645 women, mean age 74.4 years, with a relatively high level of education and income. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2003 year only

    Decreased cerebrospinal fluid acetylcholinesterase in patients with subcortical ischemic vascular dementia

    ✓ Peer-reviewed Tau biomarkers Dementia and geriatric cognitive disorders

    Key finding: CSF-AchE activity was significantly decreased compared to controls only in the SVD group (p = 0.010). +2 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2003-01-01

    The impact of comorbid disease and injuries on resource use and expenditures in parkinsonism

    ✓ Peer-reviewed Costs and economics Neurology

    Key finding: Comorbidity associated with parkinsonism is an under-recognized contribution to higher resource use and expenditures. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2003-01-01

    Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention

    ✓ Peer-reviewed Inflammation and the immune system The Journal of pharmacology and experimental therapeutics

    Key finding: Evidence from postmortem analysis implicates the involvement of microglia in the neurodegenerative process of several degenerative neurological diseases, including Alzheimer's disease and Parkinson's disease. +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2003-01-01

    The glutamatergic system and Alzheimer's disease: therapeutic implications

    ✓ Peer-reviewed Treatments CNS drugs

    Key finding: Alzheimer's disease affects nearly 5 million Americans currently and, as a result of the baby boomer cohort, is predicted to affect 14 million Americans and 22 million persons totally worldwide in just a few decades. +1 more finding

    Full summary, score breakdown and related studies → Original source

  9. 2003-01-01

    Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders

    ✓ Peer-reviewed Treatments Phytotherapy research : PTR

    Key finding: There are numerous drugs available in Western medicine that have been directly isolated from plants, or are derived from templates of compounds from plant sources. +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2003-01-01

    The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease

    ✓ Peer-reviewed Treatments CNS drug reviews

    Key finding: Memantine has been demonstrated to be safe and effective in the symptomatic treatment of Alzheimer's disease (AD). +1 more finding

    Full summary, score breakdown and related studies → Original source

  11. 2003-01-01

    Efficacy of cholinesterase inhibitors in the treatment of neuropsychiatric symptoms and functional impairment in Alzheimer disease: a meta-analysis

    ✓ Peer-reviewed Treatments JAMA

    Key finding: Cholinergic dysfunction is also associated with neuropsychiatric and functional deficits, but results from randomized controlled trials of cholinesterase inhibitors are conflicting. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2003-01-01

    Efflux of human and mouse amyloid beta proteins 1-40 and 1-42 from brain: impairment in a mouse model of Alzheimer's disease

    ✓ Peer-reviewed Drug development Neuroscience

    Key finding: The SAMP8 mouse with aging spontaneously overproduces AbetaP and develops cognitive impairments reversed by AbetaP-directed antibody or phosphorothioate antisense oligonucleotide. +4 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2003-01-01

    Melatonin rhythmicity: effect of age and Alzheimer's disease

    ✓ Peer-reviewed Brain scans and imaging Experimental gerontology

    Key finding: Whether these age-related changes (reduced melatonin amplitude, earlier timing of melatonin rhythm) are a result of aging of the retina, the SCN clock, the pineal gland, their neural connections or a combination of some or all of these is not known.

    Full summary, score breakdown and related studies → Original source

  14. 2003-01-01

    Involvement of oxidative stress in the enhancement of acetylcholinesterase activity induced by amyloid beta-peptide

    ✓ Peer-reviewed Brain scans and imaging Neuroscience research

    Key finding: In this study, using cultured retinal cells as a neuronal model, we analyzed the effect of the synthetic peptide Abeta(25-35) on the activity of AChE, the degradation enzyme of acetylcholine, as well as the involvement of oxidative stress in this process. +4 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2003-01-01

    Increased amygdala: hippocampal volume ratios associated with severity of anxiety in pediatric major depression

    ✓ Peer-reviewed Hippocampus size on brain scans Journal of child and adolescent psychopharmacology

    Key finding: These results suggest that alterations in amygdala:hippocampal volume ratios in pediatric MDD may more reflect severity of associated anxiety than depression. +3 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2003-01-01

    High-dimensional mapping of the hippocampus in depression

    ✓ Peer-reviewed Hippocampus size on brain scans The American journal of psychiatry

    Key finding: Patients with major depression may have structural abnormalities of the hippocampus that can be detected by analysis of hippocampal shape but not volume. +1 more finding

    Full summary, score breakdown and related studies → Original source

  17. 2003-01-01

    Navigation expertise and the human hippocampus: a structural brain imaging analysis

    ✓ Peer-reviewed Hippocampus size on brain scans Hippocampus

    Key finding: This change suggests that increased posterior hippocampal grey matter volume is acquired in response to increased taxi driving experience, perhaps reflecting their detailed representation of the city. +2 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2003-01-01

    Homocysteine and brain atrophy on MRI of non-demented elderly

    ✓ Peer-reviewed Hippocampus size on brain scans Brain : a journal of neurology

    Key finding: These results support the hypothesis that higher plasma homocysteine levels are associated with more atrophy of the hippocampus and cortical regions in elderly at risk of Alzheimer's disease.

    Full summary, score breakdown and related studies → Original source

  19. 2003-01-01

    MRI as a biomarker of disease progression in a therapeutic trial of milameline for AD

    ✓ Peer-reviewed Hippocampus size on brain scans Neurology

    Key finding: The consistency of MRI measurements obtained across sites, and the consistency between the multisite milameline data and that obtained in prior single-site studies, demonstrate the technical feasibility of using structural MRI measures as a surrogate endpoint of disease progression in therapeutic trials.

    Full summary, score breakdown and related studies → Original source

  20. 2003-01-01

    Assessing the older person: is the MNA a more appropriate nutritional assessment tool than the SGA?

    ✓ Peer-reviewed End-of-life care The journal of nutrition, health & aging

    Key finding: This study has shown the MNA to be a more appropriate nutrition assessment tool for older patients when compared to the SGA. +2 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2003-01-01

    Cognitive screening predicts magnitude of functional recovery from admission to 3 months after discharge in hospitalized elders

    ✓ Peer-reviewed Clinical safety The journals of gerontology. Series A, Biological sciences and medical sciences

    Key finding: Performance on a brief cognitive screen on admission was strongly related to subsequent change in function. +1 more finding

    Full summary, score breakdown and related studies → Original source

  22. 2003-01-01

    Multifactorial intervention after a fall in older people with cognitive impairment and dementia presenting to the accident and emergency department: randomised controlled trial

    ✓ Peer-reviewed Clinical safety BMJ (Clinical research ed.)

    Key finding: Multifactorial intervention was not effective in preventing falls in older people with cognitive impairment and dementia presenting to the accident and emergency department after a fall. +1 more finding

    Full summary, score breakdown and related studies → Original source

  23. 2003-01-01

    The role of diet in cognitive decline

    ✓ Peer-reviewed Prevention trials Journal of neural transmission (Vienna, Austria : 1996)

    Key finding: In particular, in an older population of Southern Italy with a typical Mediterranean diet, high monounsaturated fatty acids energy intake appeared to be associated with a high protection against cognitive decline.

    Full summary, score breakdown and related studies → Original source

  24. 2003-01-01

    Donepezil for dementia due to Alzheimer's disease

    ✓ Peer-reviewed Cognitive tests and assessment The Cochrane database of systematic reviews

    Key finding: However, some (like tacrine) are associated with adverse effects such as hepatotoxicity, but donepezil (E2020, Aricept) is safer. +4 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2003-01-01

    Memantine for dementia

    ✓ Peer-reviewed Treatments The Cochrane database of systematic reviews

    Key finding: Main results Effect of memantine in patients with moderate to severe Alzheimer's disease: analysis of the change from baseline at 28 weeks gave statistically significant results in favour of memantine for 20 mg/day on cognition (MD: 6.1. 95% CI 2.99 to 9.21, P=0.0001) activities of daily living (MD 2.10, 95% CI 0.46 to 3.74, p=0.01) and in the global clinical impression of change measured by the CIBIC-Plus at 28 weeks (MD -0.30, 95% CI -0.58 to -0.02, p=0.04), in all cases the analysis was the ITT-LOCF population (Reisberg 2000). +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →