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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 24,476–24,500 of 27,380 studies, newest first · page 980 of 1096.

May 2003 25

  1. 2003-05-16

    Systemic infection, interleukin 1beta, and cognitive decline in Alzheimer's disease

    ✓ Peer-reviewed Genetics Journal of Neurology Neurosurgery & Psychiatry

    Key finding: Breakpoints of soL1Rs suggested that a few variant mechanisms can be involved in the L1 retrotransposition processes. +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2003-05-15

    Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta

    ✓ Peer-reviewed Drug development Proceedings of the National Academy of Sciences of the United States of America

    Key finding: We found that slow rotation of Abeta1-40 solution reproducibly gave self-aggregated Abeta1-40 containing a stable and highly toxic moiety. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2003-05-14

    Amyloid-beta is found in drusen from some age-related macular degeneration retinas, but not in drusen from normal retinas

    ✓ Peer-reviewed Brain scans and imaging Molecular vision

    Key finding: Abeta was present in 4 of 9 AMD eyes. +2 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2003-05-09

    Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2

    ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America

    Key finding: This unusual protease has eluded identification, though evidence suggests that the presenilin heterodimer comprises the catalytic site and that a highly glycosylated form of nicastrin associates with it. +1 more finding

    Full summary, score breakdown and related studies → Original source

  5. 2003-05-01

    A Collaborative Study of the Emergence and Clinical Features of the Major Depressive Syndrome of Alzheimer’s Disease

    ✓ Peer-reviewed Risk factors American Journal of Psychiatry

    Key finding: Despite the use of a common, reliable methodology for the assessment and diagnosis of major depressive episodes, the prevalence of major depression in Alzheimer's disease ranged widely from 22.5% to 54.4% across the recruitment sites. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2003-05-01

    Early diagnosis of Alzheimer's disease: clinical and economic benefits

    ✓ Peer-reviewed Costs and economics Journal of the American Geriatrics Society

    Key finding: Primary care physicians have a key role in evaluating older patients for early signs of dementia and in initiating treatment that can significantly retard its progression over the maximum period of time.

    Full summary, score breakdown and related studies → Original source

  7. 2003-05-01

    Community-acquired pneumonia in very elderly patients: causative organisms, clinical characteristics, and outcomes

    ✓ Peer-reviewed Health systems and care delivery Medicine

    Key finding: Comorbidities significantly associated with older age were chronic obstructive pulmonary disease, chronic heart disease, and dementia. +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2003-05-01

    Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory

    ✓ Peer-reviewed Disease mechanisms Progress in neurobiology

    Key finding: Indeed, it has been proposed that reductions in the level or activity of certain APP fragments, in addition to accumulation of Abeta, may play a critical role in the cognitive dysfunction associated with AD, particularly early in the course of the disease. +2 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2003-05-01

    Depression as a risk factor for Alzheimer disease: the MIRAGE Study

    ✓ Peer-reviewed Risk factors Archives of neurology

    Key finding: Depression symptoms before the onset of AD are associated with the development of AD, even in families where first depression symptoms occurred more than 25 years before the onset of AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2003-05-01

    Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease

    ✓ Peer-reviewed Clinical trials Neuron

    Key finding: Patients who generated such antibodies showed significantly slower rates of decline of cognitive functions and activities of daily living, as indicated by the Mini Mental State Examination, the Disability Assessment for Dementia, and the Visual Paired Associates Test of delayed recall from the Wechsler Memory Scale, as compared to patients without such antibodies. +1 more finding

    Full summary, score breakdown and related studies → Original source

  11. 2003-05-01

    Reconstitution of gamma-secretase activity

    ✓ Peer-reviewed Risk genes beyond APOE Nature cell biology

    Key finding: Reconstituted gamma-secretase activity depends on the presence of four complex components including presenilin (PS), nicastrin (Nct), APH-1 (refs 3-6) and PEN-2 (refs 4, 7), is associated with endoproteolysis of PS, and produces Abeta and AICD in vitro.

    Full summary, score breakdown and related studies → Original source

  12. 2003-05-01

    GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

    ✓ Peer-reviewed Risk genes beyond APOE Nature

    Key finding: Alzheimer's disease is associated with increased production and aggregation of amyloid-beta (Abeta) peptides.

    Full summary, score breakdown and related studies → Original source

  13. 2003-05-01

    Effect of estrogen plus progestin on global cognitive function in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial

    ✓ Peer-reviewed Vascular contributions JAMA

    Key finding: Among postmenopausal women aged 65 years or older, estrogen plus progestin did not improve cognitive function when compared with placebo. +4 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2003-05-01

    MRI and PET study of deficits in hippocampal structure and function in women with childhood sexual abuse and posttraumatic stress disorder

    ✓ Peer-reviewed Hippocampus size on brain scans The American journal of psychiatry

    Key finding: These results are consistent with deficits in hippocampal function and structure in abuse-related PTSD. +2 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2003-05-01

    Characteristics of dementia end-of-life care across care settings

    ✓ Peer-reviewed End-of-life care The American journal of hospice & palliative care

    Key finding: Psychiatric symptoms increased caregiver burden and were the most common reason for admission to an institution, and psychiatric care was associated with longer stay at home. +1 more finding

    Full summary, score breakdown and related studies → Original source

  16. 2003-05-01

    Endogenous estradiol and risk of dementia in women and men: the Rotterdam Study

    ✓ Peer-reviewed Long-term cohort studies Annals of neurology

    Key finding: The analyses were based on a random subcohort of 508 women and 438 men, and on 76 women and 53 men with incident dementia. +3 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2003-05-01

    Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease

    ✓ Peer-reviewed Cognitive tests and assessment Neurology

    Key finding: Previous studies reported substantial contributions of neurofibrillary tangles (NFT), amyloid deposits, and neuronal loss to the development of dementia. +3 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2003-05-01

    Plasma amyloid beta protein 1-42 levels are increased in old Down Syndrome but not in young Down Syndrome

    ✓ Peer-reviewed Down syndrome and Alzheimer's Neuroscience letters

    Key finding: The higher Abeta42 levels in old DS suggests that Abeta42 is selectively increased in plasma concurrently with the development of Alzheimer disease neuropathology.

    Full summary, score breakdown and related studies → Original source

  19. 2003-05-01

    Astrocytes accumulate A beta 42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains

    ✓ Peer-reviewed Down syndrome and Alzheimer's Brain research

    Key finding: Our findings suggest that astrocytes throughout the entorhinal cortex of AD patients gradually accumulate A beta 42-positive material and that the amount of this material correlates positively with the extent of local AD pathology. +2 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2003-05-01

    Temporal lobe regions engaged during normal speech comprehension

    ✓ Peer-reviewed Digital health tools Brain : a journal of neurology

    Key finding: Thus, during normal speech comprehension, the listener is aware of the overall meaning of the speaker's utterance without the need to direct attention to individual linguistic and paralinguistic (intonational, prosodic, etc.) features contained within the speech signal. +1 more finding

    Full summary, score breakdown and related studies → Original source

  21. 2003-05-01

    Delirium in the intensive care unit: occurrence and clinical course in older patients

    ✓ Peer-reviewed How common it is Journal of the American Geriatrics Society

    Key finding: Delirium is a frequent complication in older ICU patients and often persists beyond their ICU stay. +2 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2003-05-01

    Herbs commonly used by women: an evidence-based review

    ✓ Peer-reviewed Disparities American journal of obstetrics and gynecology

    Key finding: Some herbs are medically useful, but the American public would benefit from increased regulation.

    Full summary, score breakdown and related studies → Original source

  23. 2003-05-01

    Meta-analysis of psychosocial interventions for caregivers of people with dementia

    ✓ Peer-reviewed Caregiving Journal of the American Geriatrics Society

    Key finding: Some CG interventions can reduce CG psychological morbidity and help people with dementia stay at home longer. +1 more finding

    Full summary, score breakdown and related studies → Original source

  24. 2003-05-01

    Movement Disorders Society Scientific Issues Committee report: SIC Task Force appraisal of clinical diagnostic criteria for Parkinsonian disorders

    ✓ Peer-reviewed Getting a diagnosis Movement disorders : official journal of the Movement Disorder Society

    Key finding: Clinicopathologic studies have shown significant false-positive and false-negative rates for diagnosing these disorders, and misdiagnosis is especially common during the early stages of these diseases.

    Full summary, score breakdown and related studies → Original source

  25. 2003-05-01

    Vascular dementia: distinguishing characteristics, treatment, and prevention

    ✓ Peer-reviewed Prevention and risk Journal of the American Geriatrics Society

    Key finding: Diagnosis requires the following criteria: cognitive loss, often predominantly subcortical; vascular brain lesions demonstrated by imaging; a temporal link between stroke and dementia; and exclusion of other causes of dementia.

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →