Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 24,751–24,775 of 27,380 studies, newest first · page 991 of 1096.
September 2002 19
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2002-09-01
Incidence of dementia after ischemic stroke: results of a longitudinal study
47/100 ✓ Peer-reviewed Vascular contributions Stroke
Key finding: The risk of incident dementia is high among patients with ischemic stroke, particularly in association with intercurrent medical illnesses that might cause cerebral hypoxia or ischemia, suggesting that cerebral hypoperfusion may serve as a basis for some cases of dementia after stroke. +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-09-01
Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases
36/100 ✓ Peer-reviewed Vascular contributions Neurobiology of aging
Key finding: Non-steroidal anti-inflammatory drugs (NSAIDs) show significant promise.
Full summary, score breakdown and related studies → Original source
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2002-09-01
Contributions of genetic risk and fetal hypoxia to hippocampal volume in patients with schizophrenia or schizoaffective disorder, their unaffected siblings, and healthy unrelated volunteers
40/100 ✓ Peer-reviewed Hippocampus size on brain scans The American journal of psychiatry
Key finding: These findings suggest that in patients with schizophrenia spectrum disorders, hippocampal volume is influenced in part by schizophrenia susceptibility genes and an interaction of these genes with fetal hypoxia. +2 more findings
Full summary, score breakdown and related studies → Original source
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2002-09-01
Comparison of automated and manual MRI volumetry of hippocampus in normal aging and dementia
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Journal of magnetic resonance imaging : JMRI
Key finding: Because the automatic calculations were faster and less susceptible to rater bias than manual tracing, this automated method is expected to be very useful for analyzing hippocampal changes in studies of aging and dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2002-09-01
Volumetric MRI predicts rate of cognitive decline related to AD and cerebrovascular disease
59/100 ✓ Peer-reviewed Hippocampus size on brain scans Neurology
Key finding: Hippocampal volume may index disease severity and predict progression in AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-09-01
Left hippocampal volume as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric study of nonpsychotic first-degree relatives
43/100 ✓ Peer-reviewed Hippocampus size on brain scans Archives of general psychiatry
Key finding: Compared with controls, relatives, particularly from multiplex families, had significantly smaller left hippocampi. +4 more findings
Full summary, score breakdown and related studies → Original source
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2002-09-01
Automatic differentiation of anatomical patterns in the human brain: validation with studies of degenerative dementias
41/100 ✓ Peer-reviewed Hippocampus size on brain scans NeuroImage
Key finding: In conclusion, the automated technique detects a general trend of atrophy similar to that of expertly labeled ROI measurements in AD and SD, although there are discrepancies in the ranking of severity and in the significance of volume reductions that are more marked in AD.
Full summary, score breakdown and related studies → Original source
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2002-09-01
Characterization of chemokines and their receptors in the central nervous system: physiopathological implications
44/100 ✓ Peer-reviewed Inflammation and the immune system Journal of neurochemistry
Key finding: Neurobiologists took little interest in chemokines for many years, until their link to acquired immune deficiency syndrome-associated dementia became established, and thus their importance in this field has been neglected. +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-09-01
[Neuropsychiatric symptoms of dementia: psychometric aspects of the Dutch Neuropsychiatric Inventory (NPI)]
38/100 ✓ Peer-reviewed Cognitive tests and assessment Tijdschrift voor gerontologie en geriatrie
Key finding: The Neuropsychiatric Inventory was constructed to measure these symptoms. +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-09-01
Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease
47/100 ✓ Peer-reviewed Risk genes beyond APOE Archives of neurology
Key finding: Amyloid plaques, a major pathological feature of Alzheimer disease (AD), are composed of an internal fragment of amyloid precursor protein (APP): the 4-kd amyloid-beta protein (Abeta). +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-09-01
Croatian population data for arylsulfatase a pseudodeficiency-associated mutations in healthy subjects, and in patients with Alzheimer-type dementia and Down syndrome
34/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Archives of medical research
Key finding: Frequency of two mutations associated with ASA pseudodeficiency in the Croatian population is slightly below the range reported for other populations. +4 more findings
Full summary, score breakdown and related studies → Original source
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2002-09-01
Risk factors for Alzheimer's disease: a prospective analysis from the Canadian Study of Health and Aging
56/100 ✓ Peer-reviewed Risk factors American journal of epidemiology
Key finding: Increasing age, fewer years of education, and the apolipoprotein E epsilon4 allele were significantly associated with increased risk of Alzheimer's disease. +2 more findings
Full summary, score breakdown and related studies → Original source
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2002-09-01
Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study
78/100 ✓ Peer-reviewed How common it is JAMA
Key finding: Dementia and MCI are associated with neuropsychiatric symptoms in clinical samples. +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-09-01
Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative
49/100 ✓ Peer-reviewed Brain scans and imaging Journal of neuropathology and experimental neurology
Key finding: Methoxy-X04 retains in vitro binding affinity for amyloid beta (Abeta) fibrils (Ki = 26.8 nM) very similar to that of Chrysamine-G (Ki = 25.3 nM). +4 more findings
Full summary, score breakdown and related studies → Original source
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2002-09-01
Lipid peroxidation in aging brain and Alzheimer's disease
50/100 ✓ Peer-reviewed Getting a diagnosis Free radical biology & medicine
Key finding: Numerous studies have demonstrated increased lipid peroxidation in brain of patients with Alzheimer's disease (AD) compared with age-matched controls. +4 more findings
Full summary, score breakdown and related studies → Original source
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2002-09-01
Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET
59/100 ✓ Peer-reviewed Getting a diagnosis NeuroImage
Key finding: In controls FDG uptake declined significantly with age in anterior cingulate and frontolateral perisylvian cortex. +4 more findings
Full summary, score breakdown and related studies → Original source
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2002-09-01
Six-item screener to identify cognitive impairment among potential subjects for clinical research
56/100 ✓ Peer-reviewed Getting a diagnosis Medical care
Key finding: The six-item screener is a brief and reliable instrument for identifying subjects with cognitive impairment and its diagnostic properties are comparable to the full MMSE.
Full summary, score breakdown and related studies → Original source
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2002-09-01
Predictors of functional change: a longitudinal study of nondemented people aged 65 and older
64/100 ✓ Peer-reviewed Prevention and risk Journal of the American Geriatrics Society
Key finding: Our study has identified not only risk factors associated with functional decline but also the interactions among these factors. +4 more findings
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2002-09-01
Reduced incidence of AD with NSAID but not H2 receptor antagonists: the Cache County Study
62/100 ✓ Peer-reviewed Prevention and risk Neurology
Key finding: Long-term NSAID use may reduce the risk of AD, provided such use occurs well before the onset of dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
August 2002 6
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2002-08-20
The Alzheimer's A beta -peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration
36/100 ✓ Peer-reviewed Brain scans and imaging Proceedings of the National Academy of Sciences of the United States of America
Key finding: Although drusen deposition is common in older individuals, large numbers of drusen and/or extensive areas of confluent drusen represent a significant risk factor for AMD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2002-08-07
Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning
50/100 ✓ Peer-reviewed Genetics The Journal of biological chemistry
Key finding: ApoE receptors have been indirectly implicated in memory and neurodegenerative disorders because their ligand, apoE, is genetically associated with Alzheimer disease. +2 more findings
Full summary, score breakdown and related studies → Original source
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2002-08 month only
Burden among family caregivers of persons with Alzheimer's disease in nursing homes
38/100 ✓ Peer-reviewed Caregiving The Gerontologist
Key finding: SAS PROC MIXED analysis showed burden to be associated with caregiver age, length of time involved in caregiving, custodial units, involvement in hands-on care, and expectations for care. +1 more finding
Full summary, score breakdown and related studies → Original source
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2002-08-01
Assessment of late life depression
38/100 ✓ Peer-reviewed Risk factors Biological psychiatry
Key finding: Considering disability a distinct aspect of health status may add an important dimension to the assessment of depression and result in complementary interventions aimed at depression and disability concurrently. +1 more finding
Full summary, score breakdown and related studies → Original source
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2002-08-01
Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1
36/100 ✓ Peer-reviewed Genetics Free radical biology & medicine
Key finding: Identification of specific targets of protein oxidation represents a crucial step in establishing a relationship between oxidative modification and neuronal death in AD, and was partially achieved previously in our laboratory through immunochemical detection of creatine kinase BB and beta-actin as specifically oxidized proteins in AD brain versus control brain. +1 more finding
Full summary, score breakdown and related studies → Original source
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2002-08-01
Role of superoxide dismutases in oxidative damage and neurodegenerative disorders
36/100 ✓ Peer-reviewed Vascular contributions The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
Key finding: Among the various biochemical events associated with these conditions, emerging evidence suggests the formation of superoxide anion and expression/activity of its endogenous scavenger, superoxide dismutase (SOD), as a common denominator.
Full summary, score breakdown and related studies → Original source
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