Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 25,976–26,000 of 27,380 studies, newest first · page 1040 of 1096.
April 1998 13
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1998-04-01
Frontotemporal dementia and Parkinsonism linked to chromosome 17: a new group of tauopathies
36/100 ✓ Peer-reviewed Disease mechanisms Brain pathology (Zurich, Switzerland)
Key finding: The clinical and neuropathological features of the disease in these families suggest that Frontotemporal Dementia and Parkinsonism linked to chromosome 17 is a distinct disorder.
Full summary, score breakdown and related studies → Original source
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1998-04-01
Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging
51/100 ✓ Peer-reviewed Inflammation and the immune system Neurology
Key finding: The association of immune proteins and immune-competent microglial cells with senile plaques (SP) in both AD and normal aging suggests that these drugs may be able to modify the course of AD, either by interfering with SP formation or by suppressing the inflammation associated with SP. +3 more findings
Full summary, score breakdown and related studies → Original source
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1998-04-01
Prognostic factors in very old demented adults: a seven-year follow-up from a population-based survey in Stockholm
42/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of the American Geriatrics Society
Key finding: Follow-up clinical examinations of dementia patients from a population-based study after 3- and 7-year intervals. +3 more findings
Full summary, score breakdown and related studies → Original source
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1998-04-01
Total serum homocysteine in senile dementia of Alzheimer type
40/100 ✓ Peer-reviewed Cognitive tests and assessment International journal of geriatric psychiatry
Key finding: The main hypothesis was that subtle vitamin B12 deficiencies occur more commonly in senile dementia of Alzheimer type (SDAT) that in healthy elderly individuals, and may be revealed by elevated total serum homocysteine (tHcy). +3 more findings
Full summary, score breakdown and related studies → Original source
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1998-04-01
Degeneration in vivo of rat hippocampal neurons by wild-type Alzheimer amyloid precursor protein overexpressed by adenovirus-mediated gene transfer
36/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: We first improved the efficiency of adenovirus-mediated gene transfer into neurons in vivo by using hypertonic mannitol. +3 more findings
Full summary, score breakdown and related studies → Original source
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1998-04-01
Phosphatidylinositol and inositol involvement in Alzheimer amyloid-beta fibril growth and arrest
42/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of molecular biology
Key finding: The major component is the 39 to 42 residue amyloid-beta peptide (Abeta) which is an internal proteolytic fragment of the integral membrane amyloid precursor protein. +3 more findings
Full summary, score breakdown and related studies → Original source
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1998-04-01
Platelet activation in Alzheimer disease
47/100 ✓ Peer-reviewed Risk genes beyond APOE Archives of neurology
Key finding: In light of recent reports of diminished platelet serotonin concentration and increased plasma serotonin levels in patients with Alzheimer disease (AD), we hypothesized that a state of heightened platelet activation might be present in AD. +3 more findings
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1998-04-01
Protein nitration in Parkinson's disease
44/100 ✓ Peer-reviewed Lewy body dementia Journal of neuropathology and experimental neurology
Key finding: We demonstrate here the presence of nitrotyrosine immunoreactivity in Lewy bodies within melanized neurons and in amorphous deposits associated with intact and degenerating neurons. +1 more finding
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1998-04-01
Glucose, memory, and aging
40/100 ✓ Peer-reviewed Down syndrome and Alzheimer's The American journal of clinical nutrition
Key finding: One application of this work has been to investigate whether age-related memory impairments result from dysfunctions in the neuroendocrine regulation of the brain processes responsible for memory. +3 more findings
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1998-04-01
Does delirium contribute to poor hospital outcomes? A three-site epidemiologic study
65/100 ✓ Peer-reviewed How common it is Journal of general internal medicine
Key finding: Delirium is an important independent prognostic determinant of hospital outcomes including new nursing home placement, death or new nursing home placement, and functional decline-even after controlling for age, gender, dementia, illness severity, and functional status. +2 more findings
Full summary, score breakdown and related studies → Original source
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1998-04-01
Estrogen-replacement therapy and Alzheimer's disease in the Italian Longitudinal Study on Aging
66/100 ✓ Peer-reviewed Prevention and risk Neurology
Key finding: Our data from a population-based study support the hypothesis that estrogen-replacement therapy is associated with a reduced prevalence of Alzheimer's disease in postmenopausal women. +3 more findings
Full summary, score breakdown and related studies → Original source
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1998-04-01
Senile dementia with tangles (tangle predominant form of senile dementia)
41/100 ✓ Peer-reviewed Genetics Brain pathology (Zurich, Switzerland)
Key finding: Neuropathology shows diffuse cerebral atrophy with neurofibrillary tangles, often ghost tangles, and neuropil threads almost limited to limbic areas (transentorhinal, entorhinal area, hippocampuS--not exclusively sector CA 1--and amygdala) with only rare and mild involvement of the neocortex, basal ganglia and brainstem (except nucleus basalis and locus ceruleus), absence of neuritic plaques and absence or scarcety of amyloid deposits. +4 more findings
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1998-04-01
Enhanced GFAP expression in astrocytes of transgenic mice expressing the human brain-specific trypsinogen IV
32/100 ✓ Peer-reviewed Biomarkers Glia
Key finding: Immunocytochemical analysis of the brains of transgenic mice revealed a striking enhancement of glial fibrillar acidic protein (GFAP) expression in astrocytes. +1 more finding
Full summary, score breakdown and related studies → Original source
March 1998 12
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1998-03-01
Dutch Normal-Pressure Hydrocephalus Study: randomized comparison of low- and medium-pressure shunts
45/100 ✓ Peer-reviewed Digital health tools Journal of neurosurgery
Key finding: Outcome was better for patients who had an LPV shunt than for those with an MPV shunt, although most differences were not statistically significant. +1 more finding
Full summary, score breakdown and related studies → Original source
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1998-03 month only
Placement of dementia sufferers in residential and nursing home care
50/100 ✓ Peer-reviewed Health systems and care delivery Age and ageing
Key finding: 25 (21.6%) of the 116 patients living at home were admitted to residential or nursing home care during the follow-up year. +2 more findings
Full summary, score breakdown and related studies → Original source
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1998-03-01
EEG coherence in Alzheimer's disease
36/100 ✓ Peer-reviewed Brain scans and imaging Electroencephalography and clinical neurophysiology
Key finding: Alpha coherence was significantly decreased in 6 patients, the decrease being more accentuated in the area near the electrode taken into account; a significant delta coherence increase was found in a few patients between frontal and posterior regions. +1 more finding
Full summary, score breakdown and related studies → Original source
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1998-03-01
Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia
36/100 ✓ Peer-reviewed Tau biomarkers Proceedings of the National Academy of Sciences of the United States of America
Key finding: Because monocytic infiltration of the central nervous system closely correlates with HIV-1-associated dementia, it has been suggested that monocyte-derived toxins mediate nervous system damage. +1 more finding
Full summary, score breakdown and related studies → Original source
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1998-03-01
Hippocampal atrophy and apolipoprotein E genotype are independently associated with Alzheimer's disease
47/100 ✓ Peer-reviewed Hippocampus size on brain scans Annals of neurology
Key finding: A variety of anatomic and functional neuroimaging findings are associated with Alzheimer's disease (AD). +3 more findings
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1998-03-01
Barriers to obtaining consent in dementia research: implications for surrogate decision-making
50/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society
Key finding: Absence of functional surrogate decision-makers is a major barrier to research and clinical decision-making for hospitalized patients with advanced dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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1998-03-01
Attention and driving performance in Alzheimer's disease
36/100 ✓ Peer-reviewed Clinical safety The journals of gerontology. Series B, Psychological sciences and social sciences
Key finding: The results indicated that error rate and reaction time during visual search were the best predictors of driving performance. +2 more findings
Full summary, score breakdown and related studies → Original source
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1998-03-01
Consensus Report of the Working Group on: “Molecular and Biochemical Markers of Alzheimer’s Disease”
44/100 ✓ Peer-reviewed Biomarkers Neurobiology of Aging
The ideal biomarker for Alzheimer’s disease (AD) should detect a fundamental feature of neuropathology and be validated in neuropathologically-confirmed cases; it should have a sensitivity >80% for detecting AD and a specificity of >80% for distinguishing other dementias; it should be reliable, reproducible, non-invasive, simple to perform, and inexpensive.
Full summary, score breakdown and related studies → Original source
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1998-03-01
Enlarged and phagocytic, but not primed, interleukin-1 alpha-immunoreactive microglia increase with age in normal human brain
45/100 ✓ Peer-reviewed Inflammation and the immune system Acta neuropathologica
Key finding: The strong age association of Alzheimer's disease incidence suggests that events in normal aging may promote such responses. +3 more findings
Full summary, score breakdown and related studies → Original source
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1998-03-01
Incidence and risk of dementia. The Rotterdam Study
64/100 ✓ Peer-reviewed Long-term cohort studies American journal of epidemiology
Key finding: Participants were recruited among residents of a suburb of Rotterdam, aged 55 years and older. +3 more findings
Full summary, score breakdown and related studies → Original source
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1998-03-01
Multiple neurological abnormalities in mice deficient in the G protein Go
47/100 ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America
Key finding: In vitro, Go is also activated by growth cone-associated protein of Mr 43,000 (GAP43) and the Alzheimer amyloid precursor protein, but it is not known whether this occurs in intact cells. +3 more findings
Full summary, score breakdown and related studies → Original source
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1998-03-01
Molecular mapping of Alzheimer-type dementia in Down's syndrome
54/100 ✓ Peer-reviewed Risk genes beyond APOE Annals of neurology
Key finding: We report the case of a 78-year-old woman with Down's syndrome with partial trisomy 21 [46,XX,rec(21)dup q, inv(21) (p12q22.1)]. +3 more findings
Full summary, score breakdown and related studies → Original source
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