Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 23,476–23,500 of 27,380 studies, newest first · page 940 of 1096.
October 2005 24
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2005-10-01
Mitochondria take center stage in aging and neurodegeneration
40/100 ✓ Peer-reviewed Disease mechanisms Annals of neurology
Key finding: Much of the evidence has been correlative, but recent evidence has shown that the accumulation of mitochondrial DNA mutations accelerates normal aging, leads to oxidative damage to nuclear DNA, and impairs gene transcription. +1 more finding
Full summary, score breakdown and related studies → Original source
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2005-10-01
Nonlinear dynamical analysis of EEG and MEG: review of an emerging field
36/100 ✓ Peer-reviewed Brain scans and imaging Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Key finding: Interpretation of these results in terms of 'functional sources' and 'functional networks' allows the identification of three basic patterns of brain dynamics: (i) normal, ongoing dynamics during a no-task, resting state in healthy subjects; this state is characterized by a high dimensional complexity and a relatively low and fluctuating level of synchronization of the neuronal networks; (ii) hypersynchronous, highly nonlinear dynamics of epileptic seizures; (iii) dynamics of degenerative encephalopathies with an abnormally low level of between area synchronization. +1 more finding
Full summary, score breakdown and related studies → Original source
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2005-10-01
Ribosome dysfunction is an early event in Alzheimer's disease
36/100 ✓ Peer-reviewed Genetics The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: In the present study, we report that in multiple cortical areas of MCI and AD subjects, there is a significant impairment in ribosome function that is not observed in the cerebellum of the same subjects. +2 more findings
Full summary, score breakdown and related studies → Original source
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2005-10-01
Central obesity and the aging brain
60/100 ✓ Peer-reviewed Hippocampus size on brain scans Archives of neurology
Key finding: A larger WHR may be related to neurodegenerative, vascular, or metabolic processes that affect brain structures underlying cognitive decline and dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
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2005-10-01
Chronic stress, as well as acute stress, reduces BDNF mRNA expression in the rat hippocampus but less robustly
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Neuroscience research
Key finding: In these animals, BDNF mRNA levels were significantly decreased in the hippocampus after 6 h of restraint, but the ability of restraint to reduce BDNF synthesis seemed less robust than that seen in acute stress models.
Full summary, score breakdown and related studies → Original source
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2005-10-01
The role of apoptotic pathways in Alzheimer's disease neurodegeneration and cell death
36/100 ✓ Peer-reviewed Disease mechanisms Current Alzheimer research
Key finding: Neuronal loss is associated with Alzheimer's disease (AD).
Full summary, score breakdown and related studies → Original source
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2005-10-01
Enhanced neurofibrillary tangle formation, cerebral atrophy, and cognitive deficits induced by repetitive mild brain injury in a transgenic tauopathy mouse model
38/100 ✓ Peer-reviewed Disease mechanisms Journal of neurotrauma
Key finding: Previous study showed that mild rTBI (mrTBI) accelerated the deposition of Abeta in the brains of transgenic (Tg) mice (Tg2576) that over-express human Abeta precursor proteins with the familial AD Swedish mutations (APP695swe) and model of AD-like amyloidosis. +2 more findings
Full summary, score breakdown and related studies → Original source
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2005-10-01
Long-Term Care in the St. John's Region: Impact of Single Entry and Prediction of Bed Need
41/100 ✓ Peer-reviewed Health systems and care delivery Healthcare Management Forum
Key finding: It was concluded that the single entry system was associated with improved appropriateness of NH bed utilization.
Full summary, score breakdown and related studies → Original source
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2005-10-01
Introduction: Dementia Care and Quality of Life in Assisted Living and Nursing Homes
35/100 ✓ Peer-reviewed Health systems and care delivery The Gerontologist
Key finding: Recent estimates indicate that 23% to 42% of RC/AL residents have moderate or severe dementia, as do more than 50% of nursing home residents (Zimmerman et al., 2003). +1 more finding
Full summary, score breakdown and related studies → Original source
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2005-10-01
Neuropsychiatric profiles in patients with Alzheimer's disease and vascular dementia
47/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of neurology, neurosurgery, and psychiatry
Key finding: We investigated consecutive patients with dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2005-10-01
Relationship between serum insulin-like growth factor-1 levels and Alzheimer's disease and vascular dementia
45/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of the American Geriatrics Society
Key finding: Showa University Karasuyama Hospital, Tokyo, Japan. +3 more findings
Full summary, score breakdown and related studies → Original source
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2005-10-01
Alcohol consumption and cognitive function in late life: a longitudinal community study
57/100 ✓ Peer-reviewed Cognitive tests and assessment Neurology
Key finding: Cognitive functions and self-reported drinking habits were assessed at 2-year intervals over an average of 7 years of follow-up. +3 more findings
Full summary, score breakdown and related studies → Original source
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2005-10-01
Delusions and hallucinations are associated with worse outcome in Alzheimer disease
56/100 ✓ Peer-reviewed Cognitive tests and assessment Archives of neurology
Key finding: According to all previous literature, they are not associated with mortality. +3 more findings
Full summary, score breakdown and related studies → Original source
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2005-10-01
A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease
49/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of clinical investigation
Key finding: Here we report that, in cytokine-stressed human neural cells, DHA attenuates amyloid-beta (Abeta) secretion, an effect accompanied by the formation of NPD1, a novel, DHA-derived 10,17S-docosatriene. +3 more findings
Full summary, score breakdown and related studies → Original source
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2005-10-01
Using voxel-based morphometry to map the structural changes associated with rapid conversion in MCI: a longitudinal MRI study
63/100 ✓ Peer-reviewed Mild cognitive impairment NeuroImage
Key finding: Regions of significant GM loss over the 18-month follow-up period common to both converters and non-converters included the temporal neocortex, parahippocampal cortex, orbitofrontal and inferior parietal areas, and the left thalamus. +2 more findings
Full summary, score breakdown and related studies → Original source
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2005-10-01
A systematic review of prevalence studies of dementia in Parkinson's disease
77/100 ✓ Peer-reviewed How common it is Movement disorders : official journal of the Movement Disorder Society
Key finding: There were significant methodological variations between studies and in the four studies that matched the quality criteria most closely, the rate of PDD was 31.1% (20.1-42.1). +1 more finding
Full summary, score breakdown and related studies → Original source
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2005-10-01
Brain atrophy rates predict subsequent clinical conversion in normal elderly and amnestic MCI
57/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: During follow-up, 13 healthy patients converted to MCI or Alzheimer disease (AD), whereas 39 MCI subjects converted to AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2005-10-01
Association between recurrent concussion and late-life cognitive impairment in retired professional football players
51/100 ✓ Peer-reviewed Getting a diagnosis Neurosurgery
Key finding: Our findings suggest that the onset of dementia-related syndromes may be initiated by repetitive cerebral concussions in professional football players. +4 more findings
Full summary, score breakdown and related studies → Original source
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2005-10-01
Delayed neurotoxicity in primary central nervous system lymphoma
42/100 ✓ Peer-reviewed Prevention and risk Archives of neurology
Key finding: The 5-year cumulative incidence of neurotoxicity was 24%; this incidence increases over time. +3 more findings
Full summary, score breakdown and related studies → Original source
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2005-10-01
Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease
57/100 ✓ Peer-reviewed Prevention and risk Archives of neurology
Key finding: Obesity at midlife is associated with an increased risk of dementia and AD later in life. +2 more findings
Full summary, score breakdown and related studies → Original source
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2005-10-01
Hyperinsulinemia provokes synchronous increases in central inflammation and beta-amyloid in normal adults
51/100 ✓ Peer-reviewed Treatments Archives of neurology
Key finding: Inflammation has been implicated as a pathogenetic factor in Alzheimer disease, possibly via effects on beta-amyloid (Abeta).
Full summary, score breakdown and related studies → Original source
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2005-10-01
Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials
82/100 ✓ Peer-reviewed Treatments JAMA
Key finding: Atypical antipsychotic drugs may be associated with a small increased risk for death compared with placebo. +1 more finding
Full summary, score breakdown and related studies → Original source
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2005-10-01
Serum cholesterol and risk of Alzheimer disease: a community-based cohort study
57/100 ✓ Peer-reviewed Genetics Neurology
Key finding: The data do not support an association between serum total cholesterol or high density lipoprotein in late life and subsequent risk of dementia or Alzheimer disease (AD). +4 more findings
Full summary, score breakdown and related studies → Original source
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2005-10-01
Prediction of individual clinical outcome in MCI by means of genetic assessment and (18)F-FDG PET
53/100 ✓ Peer-reviewed Genetics Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Key finding: (18)F-FDG PET of cerebral glucose metabolism is a valuable diagnostic tool for the prediction of clinical outcome in individual MCI patients. +3 more findings
Full summary, score breakdown and related studies → Original source
September 2005 1
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2005-09-30
Segmented hippocampal volume in children and adolescents with posttraumatic stress disorder
52/100 ✓ Peer-reviewed Hippocampus size on brain scans Biological psychiatry
Key finding: Future longitudinal studies with trauma control subjects and neuropsychological measures are indicated to further elucidate the relationship between hippocampus and behavioral abnormalities in young PTSD subjects. +2 more findings
Full summary, score breakdown and related studies → Original source
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