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[Biological markers for Alzheimer disease]
Tanaka T, Wada K, Yamamori H, Tanaka S, Kudo T, Takeda M.. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 2003-01-01
Topic: Amyloid, tau and blood-test diagnosis
The development of diagnostic markers for earlier and more reliable diagnosis of Alzheimer disease (AD) is essential, particularly because therapeutic medication is available for AD. Cerebrospinal fluid (CSF) is a useful source of diagnostic information. Previously we found the increase of total tau protein in CSF in normal pressure hydrocephalus patients, and others reported the increase also in corticobasal degeneration and frontotemporal dementia.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Tanaka, T., Wada, K., Yamamori, H., Tanaka, S., Kudo, T., & Takeda, M. (2003). [Biological markers for Alzheimer disease]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica.
Vancouver
Tanaka T, Wada K, Yamamori H, Tanaka S, Kudo T, Takeda M. [Biological markers for Alzheimer disease]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica. 2003. PMID: 12806899.
BibTeX
@article{tanaka2003-12806899,
author = {Tanaka, T. and Wada, K. and Yamamori, H. and Tanaka, S. and Kudo, T. and Takeda, M.},
title = {{[Biological markers for Alzheimer disease]}},
journal = {Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica},
year = {2003},
pmid = {12806899}
}
Built from the record alzhub holds for this paper, not looked up. This record has no DOI, so the citation leaves it out. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Cerebrospinal fluid (CSF) is a useful source of diagnostic information.
- Previously we found the increase of total tau protein in CSF in normal pressure hydrocephalus patients, and others reported the increase also in corticobasal degeneration and frontotemporal dementia.
- To differentiate the AD from other diseases, further approach was employed and oxidized protein in CSF was investigated.
- Heat stable fractions of CSF were analyzed on the content of carbonyl residues, which are derivatives of protein oxidization.
Why it matters
This paper discusses cerebrospinal fluid markers, including total tau and oxidized proteins, for distinguishing Alzheimer's disease from other conditions. It concerns diagnosis and does not report any treatment, cure, or prevention.
New to this subject? Start with our plain-English guide: Blood tests & biomarkers →
Study details
- Evidence strengthLow
How this study scored 30/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record and impact for its field and year, so those were left out: it earned 27 of the 90 points we could judge it on, which is 30 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2003 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 5 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.2 citations a year over 25 year(s) since 2003 |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Masatoshi Takeda: h-index 69 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | The University of Osaka: institution h-index 1,138 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 12806899) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 27 / 90 | Scored on 18 of 20 parts. We have no data for the rest, so they are left out: 27 of the 90 points we could judge it on is 30 out of 100. |
| Total | 30 / 100 | — |
What each of these 20 components measures, and what this score is not →
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