Newest studies

Predictors of rehabilitation outcomes in frail patients treated in a geriatric hospital

36/100 ✓ Peer-reviewed Risk factors Journal of the American Geriatrics Society

Key finding: The results of the present study document that severe cognitive impairment may be considered a negative predictor of functional recovery after a period of intensive rehabilitation. +2 more findings

• Care Services

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Increased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells

36/100 ✓ Peer-reviewed Drug development Neuroscience research

Key finding: In our experiments, we found increased AChE expression in apoptotic neuroblastoma SK-N-SH cells after long-term culture. +2 more findings

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Caspase activation and amyloid precursor protein cleavage in rat ocular hypertension

36/100 ✓ Peer-reviewed Brain scans and imaging Investigative ophthalmology & visual science

Key finding: Rat RGCs subjected to chronic ocular hypertension demonstrate caspase activation and abnormal processing of APP, which may contribute to the pathophysiology of glaucoma. +2 more findings

• Risk Factors

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Mapping the evolution of regional atrophy in Alzheimer's disease: unbiased analysis of fluid-registered serial MRI

36/100 ✓ Peer-reviewed Brain scans and imaging Proceedings of the National Academy of Sciences of the United States of America

Key finding: We describe a voxel-based analysis of nonlinear-registered serial MRI to demonstrate the most statistically significant (P < 0.001) regions of change at different stages of the disease. +4 more findings

• Brain Scans

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The SELDI-TOF MS approach to proteomics: protein profiling and biomarker identification

36/100 ✓ Peer-reviewed Genetics Biochemical and biophysical research communications

Key finding: Surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) is a novel approach to biomarker discovery that combines two powerful techniques: chromatography and mass spectrometry. +4 more findings

• Biomarkers

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A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

36/100 ✓ Peer-reviewed Risk genes beyond APOE The EMBO journal

Key finding: This cleavage is stimulated by apoptosis or calcium influx and occurs between human E-cadherin residues Leu731 and Arg732 at the membrane-cytoplasm interface. +4 more findings

• Genetics

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The relationship of hypertension in the elderly to AD, vascular dementia, and cognitive function

69/100 ✓ Peer-reviewed Vascular contributions Neurology

Key finding: Hypertension after age 65 years is not associated with AD and does not adversely affect memory, language, or general cognitive function. +4 more findings

• Risk Factors
• Other Dementias

Full summary, score breakdown and related studies → Original source

Medial temporal lobe atrophy predicts Alzheimer's disease in patients with minor cognitive impairment

43/100 ✓ Peer-reviewed Hippocampus size on brain scans Journal of neurology, neurosurgery, and psychiatry

Key finding: The ability to detect patients at high risk for Alzheimer type dementia among those with minor cognitive impairment increases when data on age and memory function are combined with measures of medial temporal lobe atrophy. +2 more findings

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Independent predictors of cognitive decline in healthy elderly persons

59/100 ✓ Peer-reviewed Hippocampus size on brain scans Archives of neurology

Key finding: Models combining multiple risk factors should refine the prediction of questionable dementia and persistent cognitive impairment, harbingers of dementia. +3 more findings

• Brain Scans
• Genetics

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Stress and depression: possible links to neuron death in the hippocampus

36/100 ✓ Peer-reviewed Hippocampus size on brain scans Bipolar disorders

Key finding: The subtypes of depression associated with hippocampal atrophy typically involve significant hypersecretion of glucocorticoids, the adrenal steroids secreted during stress. +1 more finding

• Brain Biology

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How common are complications of Parkinson's disease?

45/100 ✓ Peer-reviewed Clinical safety Journal of neurology

Key finding: In contrast to clinic-based samples, the most frequently occurring complications of PD in this community-based sample were axial features such as postural instability with falls. +4 more findings

• Other Dementias

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Guadeloupean parkinsonism: a cluster of progressive supranuclear palsy-like tauopathy

45/100 ✓ Peer-reviewed Disease mechanisms Brain : a journal of neurology

Key finding: Biochemical studies detected a major doublet of pathological tau at 64 and 69 kDa in brain tissue homogenates. +4 more findings

• Brain Biology
• Other Dementias

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Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

60/100 ✓ Peer-reviewed Disease mechanisms Nature

Key finding: Natural oligomers of human Abeta are formed soon after generation of the peptide within specific intracellular vesicles and are subsequently secreted from the cell. +3 more findings

• Brain Biology

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Economic Cost of Alzheimer Disease in Israel

33/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer Disease & Associated Disorders

Key finding: For community-dwelling patients, 60% of the cost represented an imputed value of unpaid indirect care compared with 12% for institutionalized patients. +3 more findings

• Policy

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Epidemiologic survey of dementia in a community-dwelling Brazilian population

51/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer disease and associated disorders

Key finding: The study was conducted in Catanduva, Brazil. +3 more findings

• Diagnosis

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Theory of mind in patients with frontal variant frontotemporal dementia and Alzheimer's disease: theoretical and practical implications

53/100 ✓ Peer-reviewed Lewy body dementia Brain : a journal of neurology

Key finding: Performance on the faux pas test revealed a double dissociation, with the fvFTD group showing deficits on ToM-based questions and the Alzheimer's disease group failing memory-based questions only. +1 more finding

• Other Dementias

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Hypertension and cerebral white matter lesions in a prospective cohort study

63/100 ✓ Peer-reviewed How common it is Brain : a journal of neurology

Key finding: Hyper tension has been associated with the presence of white matter lesions but this has been investigated almost exclusively in cross-sectional studies. +4 more findings

• Risk Factors

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HIV-associated cognitive impairment before and after the advent of combination therapy

50/100 ✓ Peer-reviewed How common it is Journal of neurovirology

Key finding: The objective of this study was to describe the occurrence of HIV dementia and neuropsychological testing abnormalities in a new cohort of HIV-seropositive individuals at high risk for HIV dementia and to compare these results to a cohort before the advent of highly active antiretroviral therapy (HAART). +1 more finding

• Treatments

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Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study

64/100 ✓ Peer-reviewed How common it is Diabetes

Key finding: Diabetes was associated with total dementia (RR 1.5 [95% CI 1.01-2.2]), Alzheimer's disease (AD; 1.8 [1.1-2.9]), and vascular dementia (VsD; 2.3 [1.1-5.0]). +3 more findings

• Genetics
• Risk Factors
• Brain Biology

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Predictors of mortality among nursing home residents with a diagnosis of Parkinson's disease

40/100 ✓ Peer-reviewed Disparities Medical science monitor : international medical journal of experimental and clinical research

Key finding: Age, sex, functional and cognitive impairment and the diagnosis of pneumonia or congestive heart failure were the strongest predictors of death.

• Health Equity
• Diagnosis
• Other Dementias

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Patient and caregiver characteristics and nursing home placement in patients with dementia

64/100 ✓ Peer-reviewed Caregiving JAMA

Key finding: Patients were divided into a development (n = 3859) and validation (n = 1929) cohort. +1 more finding

• Caregiving
• Care Services

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Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial

73/100 ✓ Peer-reviewed Treatments Lancet (London, England)

Key finding: Vascular dementia is the second commonest form of dementia, and vascular factors contribute to the development of dementia in many patients with Alzheimer's disease. +4 more findings

• Treatments
• Clinical Trials
• Other Dementias

Full summary, score breakdown and related studies → Original source

Ageing and diabetes: implications for brain function

45/100 ✓ Peer-reviewed Prevention and risk European journal of pharmacology

Key finding: Diabetes mellitus is associated with moderate cognitive deficits and neurophysiological and structural changes in the brain, a condition that may be referred to as diabetic encephalopathy.

• Risk Factors

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Alzheimer disease as a vascular disorder: nosological evidence

48/100 ✓ Peer-reviewed Prevention and risk Stroke

Key finding: Since the value of scientific evidence generally revolves around probability and chance, it is concluded that the data presented here pose a powerful argument in support of the proposal that AD should be classified as a vascular disorder. +1 more finding

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The effects of a walking/talking program on communication, ambulation, and functional status in residents with Alzheimer disease

56/100 ✓ Peer-reviewed Treatments Alzheimer disease and associated disorders

Key finding: Residents who received the walk-and-talk intervention did not demonstrate statistically significant differences in the outcome variables measured posttest when compared with residents who received the talk-only intervention or no intervention, even after controlling for individual differences. +1 more finding

• Lifestyle

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