Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 25,876–25,900 of 27,380 studies, newest first · page 1036 of 1096.
November 1998 4
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1998-11-01
Perceptions of dementia, caregiving, and help seeking among Asian and Pacific Islander Americans
38/100 ✓ Peer-reviewed Disparities Health & social work
Key finding: The United States is becoming more ethnically diverse, and Asian and Pacific Islanders (APIs) are one of the most rapidly growing ethnic minority groups. +3 more findings
Full summary, score breakdown and related studies → Original source
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1998-11-01
The efficacy of Ginkgo biloba on cognitive function in Alzheimer disease
70/100 ✓ Peer-reviewed Getting a diagnosis Archives of neurology
Key finding: Of more than 50 articles identified, the overwhelming majority did not meet inclusion criteria, primarily because of lack of clear diagnoses of dementia and AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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1998-11-01
The phenotypic spectrum of CADASIL: clinical findings in 102 cases
51/100 ✓ Peer-reviewed Getting a diagnosis Annals of neurology
Key finding: An investigation of the 18 multiplex families revealed marked intrafamilial variations.
Full summary, score breakdown and related studies → Original source
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1998-11-01
Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease
65/100 ✓ Peer-reviewed Getting a diagnosis Archives of neurology
Key finding: Serum tHcy levels were significantly higher and serum folate and vitamin B12 levels were lower in patients with DAT and patients with histologically confirmed AD than in controls. +3 more findings
Full summary, score breakdown and related studies → Original source
October 1998 14
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1998-10-01
Reduced dendritic spine density on cerebral cortical pyramidal neurons in schizophrenia
36/100 ✓ Peer-reviewed Disease mechanisms Journal of neurology, neurosurgery, and psychiatry
Key finding: The results support the concept of there being a defect in the fine structure of dendrites of pyramidal neurons, involving loss of spines, in schizophrenia and may help to explain the loss of cortical volume without loss of neurons in this condition, although the effect of neuroleptic drugs cannot be ruled out. +2 more findings
Full summary, score breakdown and related studies → Original source
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1998-10-01
Lipid peroxidation products and antioxidants in human disease
40/100 ✓ Peer-reviewed Brain scans and imaging Environmental health perspectives
Key finding: This latter form is associated mostly with cellular damage as a result of oxidative stress, which also involves cellular antioxidants in this process. +3 more findings
Full summary, score breakdown and related studies → Original source
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1998-10-01
Rate of medial temporal lobe atrophy in typical aging and Alzheimer's disease
57/100 ✓ Peer-reviewed Hippocampus size on brain scans Neurology
Key finding: A statistically significant yearly decline in hippocampal volume and an increase in temporal horn volume was identified in elderly control subjects who represent typical aging individuals. +3 more findings
Full summary, score breakdown and related studies → Original source
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1998-10-01
Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17
51/100 ✓ Peer-reviewed Lewy body dementia Proceedings of the National Academy of Sciences of the United States of America
Key finding: Transcripts that contain exon 10 encode tau isoforms with four microtubule (MT)-binding repeats (4Rtau) as opposed to tau isoforms with three MT-binding repeats (3Rtau). +4 more findings
Full summary, score breakdown and related studies → Original source
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1998-10-01
Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly
49/100 ✓ Peer-reviewed Lewy body dementia FEBS letters
Key finding: Recently exonic and intronic mutations in the gene for microtubule-associated protein tau have been discovered in cases of familial frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). +4 more findings
Full summary, score breakdown and related studies → Original source
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1998-10-01
Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation
48/100 ✓ Peer-reviewed Lewy body dementia The Journal of biological chemistry
Key finding: The presynaptic protein alpha-synuclein has been implicated in the pathogenesis of Parkinson's disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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1998-10-01
Tau protein pathology in neurodegenerative diseases
49/100 ✓ Peer-reviewed Lewy body dementia Trends in neurosciences
Key finding: Abundant tau-positive neurofibrillary lesions constitute a defining neuropathological characteristic of Alzheimer's disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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1998-10-01
Complex visual hallucinations. Clinical and neurobiological insights
47/100 ✓ Peer-reviewed Risk factors Brain : a journal of neurology
Key finding: (ii) Visual pathway lesions cause defective visual input and may result in hallucinations from defective visual processing or an abnormal cortical release phenomenon. +2 more findings
Full summary, score breakdown and related studies → Original source
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1998-10-01
A study of emotional processing in Parkinson's disease
35/100 ✓ Peer-reviewed Digital health tools Brain and cognition
Key finding: PD patients with intact cognitive functions were solely impaired at producing affectively loaded sentences, but otherwise displayed normal emotional processing abilities as compared to a clinical control group. +3 more findings
Full summary, score breakdown and related studies → Original source
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1998-10-01
Prevalence of Alzheimer's disease and other dementias in rural India: the Indo-US study
57/100 ✓ Peer-reviewed Disparities Neurology
Key finding: In this population, the prevalence of AD and other dementias was low, increased with age, and was not associated with gender or literacy. +4 more findings
Full summary, score breakdown and related studies → Original source
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1998-10-01
Predictors of institutionalization for people with dementia living at home with a carer
57/100 ✓ Peer-reviewed Caregiving International journal of geriatric psychiatry
Key finding: Both behaviour and psychological functioning and the caring environment can help in predicting which patients with dementia currently living at home will enter an institution 1 year later. +1 more finding
Full summary, score breakdown and related studies → Original source
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1998-10-01
Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial
79/100 ✓ Peer-reviewed Prevention and risk Lancet (London, England)
Key finding: Median follow-up by intention to treat was 2.0 years. +1 more finding
Full summary, score breakdown and related studies → Original source
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1998-10-01
HIV-infected subjects with the E4 allele for APOE have excess dementia and peripheral neuropathy
48/100 ✓ Peer-reviewed Genetics Nature medicine
Key finding: Compared with E4(-) subjects, twice as many E4(+) subjects were demented (30% compared with 15%) or had peripheral neuropathy (70% compared with 39%) at least once, and they had threefold more symptomatic examinations (13% compared with 3% and 42% compared with 14%, respectively)(P < 0.0001).
Full summary, score breakdown and related studies → Original source
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1998-10-01
Advanced glycation end products in Alzheimer's disease and other neurodegenerative diseases
48/100 ✓ Peer-reviewed Genetics The American journal of pathology
Key finding: These results suggest that AGE may contribute to eventual neuronal dysfunction and death as an important factor in the progression of various neurodegenerative diseases, including Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
September 1998 7
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1998-09-01
Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α‐synuclein
40/100 ✓ Peer-reviewed Brain tissue and pathology Annals of Neurology
Key finding: Recently, alpha-synuclein was shown to be a structural component of the filaments in Lewy bodies (LBs) of Parkinson's disease (PD), dementia with LBs (DLB) as well as the LB variant of Alzheimer's disease, and this suggests that alpha-synuclein could play a mechanistic role in the pathogenesis of these disorders. +2 more findings
Full summary, score breakdown and related studies → Original source
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1998-09-01
Donepezil for Treatment of Dementia With Lewy Bodies: A Case Series of Nine Patients
40/100 ✓ Peer-reviewed Treatments International Psychogeriatrics
Key finding: Treatment of DLB patients with donepezil for 12 weeks most commonly improved hallucinations, and sometimes improved cognition and overall function. +1 more finding
Full summary, score breakdown and related studies → Original source
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1998-09 month only
Tau protein in cerebrospinal fluid: a new diagnostic and prognostic marker in Alzheimer disease?
38/100 ✓ Peer-reviewed Tau biomarkers Alzheimer disease and associated disorders
Key finding: Individuals with AD had significantly higher tau levels than FLD, VD, and controls. +2 more findings
Full summary, score breakdown and related studies → Original source
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1998-09-01
Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease
36/100 ✓ Peer-reviewed Health systems and care delivery Archives of neurology
Key finding: These findings are consistent with the hypothesis that NPs are among the earliest neuropathological lesions in AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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1998-09-01
Cytokine actions in the central nervous system
36/100 ✓ Peer-reviewed Vascular contributions Cytokine & growth factor reviews
Key finding: Also, these soluble mediators have important roles in contributing to a wide array of neurological diseases such as multiple sclerosis, AIDS Dementia Complex, stroke and Alzheimer's disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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1998-09-01
Hippocampal volume and neuronal number in Ts65Dn mice: a murine model of Down syndrome
40/100 ✓ Peer-reviewed Hippocampus size on brain scans Neuroscience letters
Key finding: In order to gain insight into the cause of these deficiencies, we studied the possibility of changes in volumes and neuronal numbers in different regions of the hippocampus (dentate gyrus, CA3, CA2 and CA1) in trisomic mice as compared to control littermates using stereological methods. +2 more findings
Full summary, score breakdown and related studies → Original source
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1998-09-01
Memory impairments associated with hippocampal versus parahippocampal-gyrus atrophy: an MR volumetry study in Alzheimer's disease
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Neuropsychologia
Key finding: We examined the performance of the two groups on immediate and delayed recall trials of an auditory-verbal list-learning task (CVLT), a visual non-verbal memory task (Visual Reproduction of the WMS-R), and a screening procedure that provides an estimate of overall cognitive functioning (DRS). +4 more findings
Full summary, score breakdown and related studies → Original source
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