Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 25,251–25,275 of 27,380 studies, newest first · page 1011 of 1096.
February 2001 3
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2001-02-01
Prevalence of Alzheimer's disease, vascular dementia and dementia with Lewy bodies in a Japanese population
45/100 ✓ Peer-reviewed Disparities Psychiatry and clinical neurosciences
Key finding: The overall prevalence was higher in women for AD, while that of VD was the same in both sexes. +1 more finding
Full summary, score breakdown and related studies → Original source
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2001-02-01
A randomized, controlled trial of a home environmental intervention: effect on efficacy and upset in caregivers and on daily function of persons with dementia
66/100 ✓ Peer-reviewed Caregiving The Gerontologist
Key finding: Purpose of study The authors determined short-term effects of a home environmental intervention on self-efficacy and upset in caregivers and daily function of dementia patients.
Full summary, score breakdown and related studies → Original source
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2001-02-01
Astrocytic clasmatodendrosis in hippocampal organ culture
36/100 ✓ Peer-reviewed Biomarkers Glia
Key finding: More than 90 years ago Alzheimer showed that astrocytes lose their distal processes (i.e., undergo "clasmatodendrosis") when irreversibly injured by a reduction in blood flow, a process shown by Friede and van Houten (1961) to be due to energy failure and acidosis. +2 more findings
Full summary, score breakdown and related studies → Original source
January 2001 22
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2001-01-10
Evidence for a partially folded intermediate in alpha-synuclein fibril formation
36/100 ✓ Peer-reviewed Brain tissue and pathology The Journal of biological chemistry
Key finding: This raises the question of how an essentially disordered protein is transformed into highly organized fibrils. +4 more findings
Full summary, score breakdown and related studies → Original source
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2001-01-09
Incidence of AD in African-Americans, Caribbean Hispanics, and Caucasians in northern Manhattan
52/100 ✓ Peer-reviewed Disparities Neurology
The incidence rate for AD was significantly higher among African-American and Caribbean Hispanic elderly individuals compared white individuals.
Full summary, score breakdown and related studies → Original source
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2001-01-01
CRMP-5 neuronal autoantibody: Marker of lung cancer and thymoma-related autoimmunity
48/100 ✓ Peer-reviewed Disease mechanisms Annals of Neurology
Key finding: Clinical information, obtained for 116 patients, revealed multifocal neurological signs. +1 more finding
Full summary, score breakdown and related studies → Original source
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2001-01-01
Pericytes: Cell Biology and Pathology
36/100 ✓ Peer-reviewed Vascular contributions Cells Tissues Organs
Key finding: The coverage of EC by pericytes varies considerably between different microvessel types and the location of pericytes on the microvessel is not random but appears to be functionally determined. +4 more findings
Full summary, score breakdown and related studies → Original source
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2001 year only
Late life depression
38/100 ✓ Peer-reviewed Risk factors European archives of psychiatry and clinical neuroscience
Key finding: Depression has an overall prevalence of 5-8%. +2 more findings
Full summary, score breakdown and related studies → Original source
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2001 year only
Economic evaluations during early (phase II) drug development: a role for clinical trial simulations?
38/100 ✓ Peer-reviewed Clinical trials PharmacoEconomics
Key finding: The results demonstrate how the modelling may be of value in 'go/no-go' decisions during the drug development programme.
Full summary, score breakdown and related studies → Original source
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2001 year only
Tacrine and rate of progression in Alzheimer's disease--relation to ApoE allele genotype
43/100 ✓ Peer-reviewed Genetics Journal of neural transmission (Vienna, Austria : 1996)
Key finding: No differences were found after 6 months of treatment, but after 12 months the CIBIC scores revealed that the ApoE4 patients had declined more than the ApoE2-3 patients (p < 0.05). +1 more finding
Full summary, score breakdown and related studies → Original source
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2001-01-01
Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease
40/100 ✓ Peer-reviewed Cognitive tests and assessment Neurology
Key finding: Compared with control subjects (CDR = 0), mild (early) AD (CDR = 0.5 to 1) cases had a 25% loss of synaptophysin immunoreactivity.
Full summary, score breakdown and related studies → Original source
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2001-01-01
Down syndrome and Alzheimer's disease: a link between development and aging
41/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Mental retardation and developmental disabilities research reviews
Key finding: A review of the existing literature indicates that oxidative damage and neuroinflammation may interact to accelerate the disease process particularly in individuals with DS over the age of 40 years.
Full summary, score breakdown and related studies → Original source
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2001-01-01
Sleep disturbances in patients with Alzheimer's disease: epidemiology, pathophysiology and treatment
36/100 ✓ Peer-reviewed Health systems and care delivery CNS drugs
Key finding: A common complaint in both normal aging and the dementias is that of significant sleep disturbance. +2 more findings
Full summary, score breakdown and related studies → Original source
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2001-01-01
Prevalence and pharmacological management of behavioural and psychological symptoms amongst dementia sufferers living in care environments
36/100 ✓ Peer-reviewed Caregiving International journal of geriatric psychiatry
Key finding: BPSD are common in elderly people with dementia living in care environments. +1 more finding
Full summary, score breakdown and related studies → Original source
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2001-01-01
Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment
36/100 ✓ Peer-reviewed Inflammation and the immune system Drugs & aging
Key finding: Indeed, it has been shown that proteasomal inhibition increases levels of oxidative damage not only to proteins but also to other biomolecules.
Full summary, score breakdown and related studies → Original source
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2001-01-01
A new therapeutic target in Alzheimer's disease treatment: attention to butyrylcholinesterase
36/100 ✓ Peer-reviewed Treatments Current medical research and opinion
Key finding: Recent evidence suggests that BuChE may also have a role in the aetiology and progression of AD beyond regulation of synaptic ACh levels.
Full summary, score breakdown and related studies → Original source
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2001-01-01
Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice
36/100 ✓ Peer-reviewed Risk genes beyond APOE The EMBO journal
Key finding: Our results demonstrate that in vivo overexpression of GSK-3beta results in neurodegeneration and suggest that these mice can be used as an animal model to study the relevance of GSK-3beta deregulation to the pathogenesis of Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
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2001-01-01
Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain
36/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of neurochemistry
Key finding: We describe a novel class of compounds that reduce A beta production by functionally inhibiting gamma-secretase, the activity responsible for the carboxy-terminal cleavage required for A beta production. +4 more findings
Full summary, score breakdown and related studies → Original source
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2001-01-01
Protein oxidation in the brain in Alzheimer's disease
36/100 ✓ Peer-reviewed Biomarkers Neuroscience
Key finding: In two brain regions severely affected by Alzheimer's disease pathology, prominent protein carbonyl immunoreactivity was localized in the cytoplasm of neurons without visual pathomorphological changes and degenerating neurons, suggesting that intracellular proteins might be significantly affected by oxidative modifications. +3 more findings
Full summary, score breakdown and related studies → Original source
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2001-01-01
Biology of posttraumatic stress disorder
36/100 ✓ Peer-reviewed Hippocampus size on brain scans The Journal of clinical psychiatry
Key finding: However, over the last 10 years, biological observations have been made in PTSD that are different from what has been typically associated with chronic stress, notably certain hypothalamic-pituitary-adrenal (HPA) axis findings. +2 more findings
Full summary, score breakdown and related studies → Original source
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2001-01-01
Neuroimaging studies of the hippocampus in schizophrenia
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Hippocampus
Key finding: Functional neuroimaging studies have demonstrated abnormal levels of hippocampal activity at rest, during the experience of auditory hallucinations, and during the performance of memory retrieval tasks. +1 more finding
Full summary, score breakdown and related studies → Original source
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2001-01-01
Ethnicity and end-of-life care: the use of feeding tubes
57/100 ✓ Peer-reviewed End-of-life care Ethnicity & disease
Key finding: Feeding tube use is significantly more common in Blacks than in Whites. +4 more findings
Full summary, score breakdown and related studies → Original source
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2001-01-01
Family caregiving in hospice: effects on psychological and health functioning among spousal caregivers of hospice patients with lung cancer or dementia
36/100 ✓ Peer-reviewed End-of-life care The Hospice journal
Key finding: Hospice family caregivers are at high risk for both psychological and physical health disorders, and caregiver depression and health problems should be systematically assessed and treated by the hospice team. +3 more findings
Full summary, score breakdown and related studies → Original source
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2001-01-01
Synergistic neurotoxicity of opioids and human immunodeficiency virus-1 Tat protein in striatal neurons in vitro
36/100 ✓ Peer-reviewed Inflammation and the immune system Neuroscience
Key finding: Morphine (10nM, 100nM or 1microM) significantly increased Tat-induced (100 or 200nM) neuronal losses by about two-fold at 24h following exposure. +1 more finding
Full summary, score breakdown and related studies → Original source
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2001 no date recorded — placed by publication year
Pathologic Correlates of Nondemented Aging, Mild Cognitive Impairment, and Early-Stage Alzheimer's Disease
44/100 ✓ Peer-reviewed Brain tissue and pathology Journal of Molecular Neuroscience
Full summary, score breakdown and related studies → Original source
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