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Age-dependent cognitive decline in the APP23 model precedes amyloid deposition
Van Dam D, D'Hooge R, Staufenbiel M, Van Ginneken C, Van Meir F, De Deyn PP.. The European journal of neuroscience, 2003-01-01
Topic: Amyloid, tau and blood-test diagnosis
Heterozygous APP23 mice, expressing human amyloid-precursor protein with the Swedish double mutation and control littermates, were subjected to behavioral and neuromotor tasks at the age of 6-8 weeks, 3 and 6 months. A hidden-platform Morris-type water maze showed an age-dependent decline of spatial memory capacities in the APP23 model. From the age of 3 months onwards, the APP23 mice displayed major learning and memory deficits as demonstrated by severely impaired learning curves during acquisition and impaired probe trial performance.
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APA 7th
Van Dam, D., D'Hooge, R., Staufenbiel, M., Van Ginneken, C., Van Meir, F., & De Deyn, P. P. (2003). Age-dependent cognitive decline in the APP23 model precedes amyloid deposition. The European journal of neuroscience. https://doi.org/10.1046/j.1460-9568.2003.02444.x
Vancouver
Van Dam D, D'Hooge R, Staufenbiel M, Van Ginneken C, Van Meir F, De Deyn PP. Age-dependent cognitive decline in the APP23 model precedes amyloid deposition. The European journal of neuroscience. 2003. doi:10.1046/j.1460-9568.2003.02444.x. PMID: 12542676.
BibTeX
@article{vandam2003-12542676,
author = {Van Dam, D. and D'Hooge, R. and Staufenbiel, M. and Van Ginneken, C. and Van Meir, F. and De Deyn, P. P.},
title = {{Age-dependent cognitive decline in the APP23 model precedes amyloid deposition}},
journal = {The European journal of neuroscience},
year = {2003},
doi = {10.1046/j.1460-9568.2003.02444.x},
pmid = {12542676},
url = {https://doi.org/10.1046/j.1460-9568.2003.02444.x}
}
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Key findings
- A hidden-platform Morris-type water maze showed an age-dependent decline of spatial memory capacities in the APP23 model.
- From the age of 3 months onwards, the APP23 mice displayed major learning and memory deficits as demonstrated by severely impaired learning curves during acquisition and impaired probe trial performance.
- In addition to the cognitive deficit, APP23 mice displayed disturbed activity patterns.
- Overnight cage-activity recording showed hyperactivity in the transgenics for the three age groups tested.
Why it matters
In the APP23 mouse model, age-dependent cognitive decline appeared before amyloid deposition, with major learning and memory deficits from 3 months of age. This is animal research and does not test a treatment or cure for people.
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Study details
- Evidence strengthLow
How this study scored 47/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The European journal of neuroscience) |
| Journal's citation record | 3 / 4 | European Journal of Neuroscience: journal h-index 277 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2003 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 297 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 11.9 citations a year over 25 year(s) since 2003 |
| Impact for its field and year | 4 / 6 | Cited 11.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 4 other studies in this library |
| Still being cited | 2 / 4 | Cited 30 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Peter Paul De Deyn: h-index 103 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Antwerp: institution h-index 834 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 12542676) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 47 / 100 | — |
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Also tagged “precursor”
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