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Enlarged amygdala volume and reduced hippocampal volume in young women with major depression
Lange C, Irle E.. Psychological medicine, 2004-08-01
Topic: Brain proteins, microglia and lab models
Background Evidence is increasing that amygdala and hippocampus show significant structural abnormalities in affective disorders. Two previous studies found enlarged amygdala size in subjects with recent-onset major depression. Method Amygdala and hippocampal volumes were assessed in 17 young women with major depressive disorder and 17 healthy matched control subjects by use of three-dimensional structural magnetic resonance imaging. The severity of depressive symptoms was assessed using the Hamilton Depression Scale and the Beck Depression Inventory. Results Compared with control subjects, depressive subjects had significantly larger (+13 %) amygdala volumes and significantly smaller (-12%) hippocampal volumes. Amygdala and hippocampal volumes were not significantly correlated with disorder-related variables. Conclusions Our results are consistent with previous findings of structural abnormalities of amygdala and hippocampus in subjects with recent-onset major depression. It may be suggested that the size of the amygdala is enlarged in the first years of the disorder, and may decrease with prolonged disorder duration.
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APA 7th
Lange, C., & Irle, E. (2004). Enlarged amygdala volume and reduced hippocampal volume in young women with major depression. Psychological medicine. https://doi.org/10.1017/s0033291703001806
Vancouver
Lange C, Irle E. Enlarged amygdala volume and reduced hippocampal volume in young women with major depression. Psychological medicine. 2004. doi:10.1017/s0033291703001806. PMID: 15554576.
BibTeX
@article{lange2004-15554576,
author = {Lange, C. and Irle, E.},
title = {{Enlarged amygdala volume and reduced hippocampal volume in young women with major depression}},
journal = {Psychological medicine},
year = {2004},
doi = {10.1017/s0033291703001806},
pmid = {15554576},
url = {https://doi.org/10.1017/s0033291703001806}
}
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Key findings
- Background Evidence is increasing that amygdala and hippocampus show significant structural abnormalities in affective disorders.
- Results Compared with control subjects, depressive subjects had significantly larger (+13 %) amygdala volumes and significantly smaller (-12%) hippocampal volumes.
- Amygdala and hippocampal volumes were not significantly correlated with disorder-related variables.
- Conclusions Our results are consistent with previous findings of structural abnormalities of amygdala and hippocampus in subjects with recent-onset major depression.
- It may be suggested that the size of the amygdala is enlarged in the first years of the disorder, and may decrease with prolonged disorder duration.
Study details
- Evidence strengthLow
How this study scored 36/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 21 of the 58 points we could judge it on, which is 36 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Psychological medicine) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2004 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 15554576) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 21 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 21 of the 58 points we could judge it on is 36 out of 100. |
| Total | 36 / 100 | — |
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