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Mapping hippocampal and ventricular change in Alzheimer disease
Thompson PM, Hayashi KM, De Zubicaray GI, Janke AL, Rose SE, Semple J, Hong MS, Herman DH et al.. NeuroImage, 2004-08-01
Topic: Amyloid, tau and blood-test diagnosis
We developed an anatomical mapping technique to detect hippocampal and ventricular changes in Alzheimer disease (AD). The resulting maps are sensitive to longitudinal changes in brain structure as the disease progresses. An anatomical surface modeling approach was combined with surface-based statistics to visualize the region and rate of atrophy in serial MRI scans and isolate where these changes link with cognitive decline. Sixty-two [corrected] high-resolution MRI scans were acquired from 12 AD patients (mean [corrected] age +/- SE at first scan: 68.7 +/- 1.7 [corrected] years) and 14 matched controls (age: 71.4 +/- 0.9 years) [corrected] each scanned twice (1.9 +/- 0.2 [corrected] years apart, when all subjects are pooled [corrected] 3D parametric mesh models of the hippocampus and temporal horns were created in sequential scans and averaged across subjects to identify systematic patterns of atrophy. As an index of radial atrophy, 3D distance fields were generated relating each anatomical surface point to a medial curve threading down the medial axis of each structure. Hippocampal atrophic rates and ventricular expansion were assessed statistically using surface-based permutation testing and were faster in AD than in controls. Using color-coded maps and video sequences, these changes were visualized as they progressed anatomically over time. Additional maps localized regions where atrophic changes linked with cognitive decline. Temporal horn expansion maps were more sensitive to AD progression than maps of hippocampal atrophy, but both maps correlated with clinical deterioration. These quantitative, dynamic visualizations of hippocampal atrophy and ventricular expansion rates in aging and AD may provide a promising measure to track AD progression in drug trials.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Thompson, P. M., Hayashi, K. M., De Zubicaray, G. I., Janke, A. L., Rose, S. E., Semple, J., et al. (2004). Mapping hippocampal and ventricular change in Alzheimer disease. NeuroImage. https://doi.org/10.1016/j.neuroimage.2004.03.040
Vancouver
Thompson PM, Hayashi KM, De Zubicaray GI, Janke AL, Rose SE, Semple J, et al. Mapping hippocampal and ventricular change in Alzheimer disease. NeuroImage. 2004. doi:10.1016/j.neuroimage.2004.03.040. PMID: 15275931.
BibTeX
@article{thompson2004-15275931,
author = {Thompson, P. M. and Hayashi, K. M. and De Zubicaray, G. I. and Janke, A. L. and Rose, S. E. and Semple, J. and Hong, M. S. and Herman, D. H. and others},
title = {{Mapping hippocampal and ventricular change in Alzheimer disease}},
journal = {NeuroImage},
year = {2004},
doi = {10.1016/j.neuroimage.2004.03.040},
pmid = {15275931},
url = {https://doi.org/10.1016/j.neuroimage.2004.03.040}
}
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Key findings
- Hippocampal atrophic rates and ventricular expansion were assessed statistically using surface-based permutation testing and were faster in AD than in controls.
- Using color-coded maps and video sequences, these changes were visualized as they progressed anatomically over time.
- Additional maps localized regions where atrophic changes linked with cognitive decline.
- Temporal horn expansion maps were more sensitive to AD progression than maps of hippocampal atrophy, but both maps correlated with clinical deterioration.
- These quantitative, dynamic visualizations of hippocampal atrophy and ventricular expansion rates in aging and AD may provide a promising measure to track AD progression in drug trials.
Why it matters
Using serial MRI in 12 Alzheimer patients and 14 controls, hippocampal atrophy and ventricular expansion were faster in Alzheimer disease than in controls, and these changes were linked with cognitive decline. Temporal horn expansion maps were more sensitive to disease progression than maps of hippocampal atrophy.
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Study details
- Study designlongitudinal study
- Evidence strengthModerate
How this study scored 61/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (NeuroImage) |
| Journal's citation record | 4 / 4 | NeuroImage: journal h-index 523 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2004 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 612 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 25.5 citations a year over 24 year(s) since 2004 |
| Impact for its field and year | 4 / 6 | Cited 13.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 29 other studies in this library |
| Still being cited | 2 / 4 | Cited 48 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Arthur W. Toga: h-index 179 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of California, Los Angeles: institution h-index 1,923 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 15275931) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 61 / 100 | — |
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