Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 23,351–23,375 of 27,380 studies, newest first · page 935 of 1096.
January 2006 10
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2006-01-01
Clinicopathologic analysis of frontotemporal and corticobasal degenerations and PSP
54/100 ✓ Peer-reviewed Getting a diagnosis Neurology
Key finding: Frontotemporal lobar degeneration, corticobasal degeneration (CBD), and progressive supranuclear palsy (PSP) have overlapping clinical features.
Full summary, score breakdown and related studies → Original source
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2006-01-01
Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the Consortium on DLB International Workshop
46/100 ✓ Peer-reviewed Getting a diagnosis Journal of Alzheimer's disease : JAD
Key finding: Subsequent recognition that 10-15% of dementia cases in older people were associated with Lewy body pathology led to the publication in 1996 of Consensus clinical and pathological diagnostic criteria for the disorder.
Full summary, score breakdown and related studies → Original source
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2006-01-01
The diagnosis of Parkinson's disease
52/100 ✓ Peer-reviewed Getting a diagnosis The Lancet. Neurology
Key finding: Clinicopathological studies based on brain bank material from the UK and Canada have shown that clinicians diagnose the disease incorrectly in about 25% of patients.
Full summary, score breakdown and related studies → Original source
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2006-01-01
Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older
75/100 ✓ Peer-reviewed Prevention and risk Annals of internal medicine
Key finding: These results suggest that regular exercise is associated with a delay in onset of dementia and Alzheimer disease, further supporting its value for elderly persons. +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-01-01
Circulating cholesterol levels, apolipoprotein E genotype and dementia severity influence the benefit of atorvastatin treatment in Alzheimer's disease: results of the Alzheimer's Disease Cholesterol-Lowering Treatment (ADCLT) trial
60/100 ✓ Peer-reviewed Treatments Acta neurologica Scandinavica. Supplementum
Key finding: Atorvastatin therapy may be of benefit in the treatment of mild-to-moderately affected AD patients, but the level of benefit produced may be predicated on earlier treatment, an individual's apolipoprotein E genotype or whether the patient exhibits elevated cholesterol levels. +2 more findings
Full summary, score breakdown and related studies → Original source
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2006-01-01
A 24-week open-label extension study of memantine in moderate to severe Alzheimer disease
65/100 ✓ Peer-reviewed Treatments Archives of neurology
Key finding: This study is an extension of a 28-week, randomized, double-blind, placebo-controlled study of memantine in 252 patients with moderate to severe Alzheimer disease.
Full summary, score breakdown and related studies → Original source
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2006-01-01
Apolipoprotein E and Alzheimer disease
45/100 ✓ Peer-reviewed Genetics Neurology
Key finding: Unlike apoE3, the most common isoform, apoE4, is associated with increased risk of developing Alzheimer disease (AD) and other neurodegenerative disorders. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-01-01
Cholesterol, APOE genotype, and Alzheimer disease: an epidemiologic study of Nigerian Yoruba
62/100 ✓ Peer-reviewed Genetics Neurology
Key finding: There was a significant interaction between cholesterol, APOE-epsilon4, and the risk of Alzheimer disease (AD) in the Yoruba, a population that has lower cholesterol levels and lower incidence rates of AD compared to African Americans. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-01-01
Apolipoprotein E genotype and age-related myelin breakdown in healthy individuals: implications for cognitive decline and dementia
53/100 ✓ Peer-reviewed Genetics Archives of general psychiatry
Key finding: In later-myelinating regions, the severity and rate of myelin breakdown in healthy older individuals are associated with APOE status and support the hypothesis that this process may contribute to age at onset of AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-01-01
Plasma beta-amyloid and white matter lesions in AD, MCI, and cerebral amyloid angiopathy
62/100 ✓ Peer-reviewed Genetics Neurology
Key finding: If confirmed in longitudinal studies, these data would suggest circulating beta-amyloid peptide as a novel biomarker or risk factor for microvascular damage in these common diseases of the elderly. +1 more finding
Full summary, score breakdown and related studies → Original source
December 2005 15
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2005-12-27
Identification of nitrated proteins in Alzheimer's disease brain using a redox proteomics approach
36/100 ✓ Peer-reviewed Genetics Neurobiology of disease
Key finding: In the present study, using a proteomics approach, we identified enolase, glyceraldehyde-3-phosphate dehydrogenase, ATP synthase alpha chain, carbonic anhydrase-II, and voltage-dependent anion channel-protein as the targets of nitration in AD hippocampus, a region that shows a extensive deposition of amyloid beta-peptide, compared with the age-matched control brains. +1 more finding
Full summary, score breakdown and related studies → Original source
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2005-12-20
Mechanism of action of memantine
36/100 ✓ Peer-reviewed Treatments Current opinion in pharmacology
Key finding: The unusual therapeutic utility of memantine probably results from inhibitory mechanisms shared with ketamine, combined with actions specific to memantine.
Full summary, score breakdown and related studies → Original source
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2005-12-20
Rapamycin alleviates toxicity of different aggregate-prone proteins
36/100 ✓ Peer-reviewed Disease mechanisms Human molecular genetics
Key finding: Previously, we showed that rapamycin, an autophagy inducer, enhances mutant huntingtin fragment clearance and attenuated toxicity. +1 more finding
Full summary, score breakdown and related studies → Original source
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2005-12-20
APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy
58/100 ✓ Peer-reviewed Brain tissue and pathology Nature genetics
Key finding: Among these families, the duplicated segments had a minimal size ranging from 0.58 to 6.37 Mb. +2 more findings
Full summary, score breakdown and related studies → Original source
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2005-12-19
Disenrollment From an Acute/Long-Term Managed Care Program (PACE)
42/100 ✓ Peer-reviewed Health systems and care delivery Medical Care
Key finding: Our findings show a low level of disenrollment. +4 more findings
Full summary, score breakdown and related studies → Original source
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2005-12-16
A prospective longitudinal study of apathy in Alzheimer's disease
48/100 ✓ Peer-reviewed Clinical safety Journal of Neurology Neurosurgery & Psychiatry
Key finding: Apathy was significantly associated with older age (p = 0.009), and a higher frequency of minor and major depression (p < 0.0001). +2 more findings
Full summary, score breakdown and related studies → Original source
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2005-12-16
Lawsuit Challenges Medicare Part D Transition Plan For Dual Eligibles
22/100 ✓ Peer-reviewed Health systems and care delivery Psychiatric News
Key finding: But advocacy groups, including APA, have been bracing for enormous complications with transitioning these beneficiaries— some 2 million of whom are believed to have mental illness—into the new program.
Full summary, score breakdown and related studies → Original source
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2005-12-16
Stage-dependent BDNF serum concentrations in Alzheimer's disease
46/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of neural transmission (Vienna, Austria : 1996)
Key finding: Recent findings have suggested an involvement of brain-derived neurotrophic factor (BDNF) in the pathogenesis of AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2005-12-15
The assessment of cognitive function in advanced HIV-1 infection and AIDS dementia complex using a new computerised cognitive test battery
47/100 ✓ Peer-reviewed Cognitive tests and assessment Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists
Key finding: The computerised assessment demonstrated a good sensitivity of 81.1% and specificity of 69.9% as well as good positive predictive value (81%) and acceptable construct validity (.45-.62).
Full summary, score breakdown and related studies → Original source
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2005-12-15
Glutamate-based therapeutic approaches: clinical trials with NMDA antagonists
47/100 ✓ Peer-reviewed Vascular contributions Current opinion in pharmacology
Key finding: Systematic reviews in stroke and TBI have shown that definitive conclusions cannot be drawn for most agents owing to early termination of trials.
Full summary, score breakdown and related studies → Original source
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2005-12-14
Astroglial plasticity in the hippocampus is affected by chronic psychosocial stress and concomitant fluoxetine treatment
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Key finding: Analysis of post-mortem tissue from patients with affective disorders has revealed a decreased number of glial cells in several brain areas. +2 more findings
Full summary, score breakdown and related studies → Original source
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2005-12-13
Principal components analysis of Laplacian waveforms as a generic method for identifying ERP generator patterns: I. Evaluation with auditory oddball tasks
44/100 ✓ Peer-reviewed Lewy body dementia Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Key finding: CSD transformation is shown to be a valuable preprocessing step for PCA of ERP data, providing a unique, physiologically meaningful solution to the ubiquitous reference problem. +3 more findings
Full summary, score breakdown and related studies → Original source
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2005-12-09
Activation of Toll-like receptor 2 on microglia promotes cell uptake of Alzheimer disease-associated amyloid beta peptide
47/100 ✓ Peer-reviewed Inflammation and the immune system The Journal of biological chemistry
Key finding: Because mFPR2 was inducible in mouse microglial cells by proinflammatory stimulants, such as bacterial lipopolysaccharide, a ligand for the Toll-like receptor 4 (TLR4), we investigated the role of TLR2 in the regulation of mFPR2. +3 more findings
Full summary, score breakdown and related studies → Original source
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2005-12-02
Advance care planning documents in nursing facilities: results from a nationally representative survey
38/100 ✓ Peer-reviewed End-of-life care Archives of gerontology and geriatrics
Key finding: This study assessed clinical, demographic, facility, and regional factors associated with documented do-not-resuscitate (DNR) orders, feeding/medication/other treatment (FMT) restrictions, and living wills among nursing facility residents.
Full summary, score breakdown and related studies → Original source
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2005-12-01
‘AND A TIME TO DIE
34/100 ✓ Peer-reviewed End-of-life care Oncology Times
Key finding: Kaufman, “dying people are not wanted in medical institutions, and it shows.” +4 more findings
Full summary, score breakdown and related studies → Original source
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