Newest studies

Long-term donepezil use for dementia with Lewy bodies: results from an open-label extension of Phase III trial

52/100 ✓ Peer-reviewed Treatments Alzheimer's Research & Therapy

Key finding: In total, 100 subjects completed the study. +4 more findings

• Clinical Trials
• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Donepezil for dementia with Lewy bodies: a randomized, placebo-controlled, confirmatory phase III trial

48/100 ✓ Peer-reviewed Treatments Alzheimer's Research & Therapy

Key finding: The predefined superiority of donepezil to the placebo was not confirmed in either active group in the primary analysis. +4 more findings

• Treatments
• Clinical Trials
• Other Dementias

Full summary, score breakdown and related studies → Original source

Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949)

86/100 ✓ Peer-reviewed Genetics Molecular psychiatry

Key finding: We report 13 genome-wide significant single-nucleotide polymorphism (SNP) associations in three genomic regions, 6q16.1, 14q12 and 19q13.32 (best SNP and closest gene, respectively: rs10457441, P=3.93 × 10(-9), MIR2113; rs17522122, P=2.55 × 10(-8), AKAP6; rs10119, P=5.67 × 10(-9), APOE/TOMM40). +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

End-of-life decisions in individuals dying with dementia in Belgium

54/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society

Key finding: The intense pain and symptoms of individuals with dementia was alleviated less often than those of individuals with cancer (odds ratio (OR) = 0.50, P < .001), and individuals with dementia were more likely to have life-prolonging treatment withheld or withdrawn (OR = 1.40, P = .048). +4 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Characterization of Dementia and Alzheimer’s Disease in an Older Population: Updated Incidence and Life Expectancy With and Without Dementia

46/100 ✓ Peer-reviewed How common it is American Journal of Public Health

Key finding: Efforts to delay onset of dementia, if successful, would likely benefit older adults of all ages. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Second-Generation Antipsychotics and Tardive Syndromes in Affective Illness: A Public Health Problem With Neuropsychiatric Consequences

36/100 ✓ Peer-reviewed Clinical safety American Journal of Public Health

Key finding: Updated literature challenges safety advantages of atypical versus typical antipsychotics.

• Side Effects

Full summary, score breakdown and related studies → Original source

Nonpharmacological Therapeutic Techniques to Decrease Agitation in Geriatric Psychiatric Patients With Dementia

36/100 ✓ Peer-reviewed Clinical safety Journal of Gerontological Nursing

Key finding: Many serious problems and side effects are associated with the use of medications to treat agitation; therefore, alternative approaches to treating agitation must be assessed. +3 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Sleep‐like behavior and 24‐h rhythm disruption in the Tc1 mouse model of Down syndrome

36/100 ✓ Peer-reviewed Risk factors Genes, Brain and Behavior

Key finding: Down syndrome is a common disorder associated with intellectual disability in humans. +1 more finding

• Brain Biology
• Down Syndrome
• Lifestyle

Full summary, score breakdown and related studies → Original source

Chronology and Chronicity of Altered Resting-State Functional Connectivity after Traumatic Brain Injury

54/100 ✓ Peer-reviewed Brain scans and imaging Journal of Neurotrauma

Key finding: Whereas traumatic brain injury (TBI) results in widespread disruption of neural networks, changes in regional resting-state functional connectivity patterns after insult remain unclear. +3 more findings

• Brain Scans
• Risk Factors

Full summary, score breakdown and related studies → Original source

A Peptide Antagonist of Thrombospondin-1 Promotes Abdominal Aortic Aneurysm Progression in the Angiotensin II–Infused Apolipoprotein-E–Deficient Mouse

36/100 ✓ Peer-reviewed Genetics Arteriosclerosis, Thrombosis, and Vascular Biology

Key finding: LSKL peptide administration was associated with greater aortic elastin fragmentation and lower expression and activity of the TGF-β1-target gene lysyl oxidase like 1 ( LOXL1 ). +2 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Angiotensin II Mobilizes Spleen Monocytes to Promote the Development of Abdominal Aortic Aneurysm in Apoe −/− Mice

36/100 ✓ Peer-reviewed Genetics Arteriosclerosis, Thrombosis, and Vascular Biology

Key finding: Intriguingly, the process is dependent on the presence of B cells and significantly contributes to the development of AAA and the occurrence of aortic rupture. +4 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

The ApoE Gene Is Related with Exceptional Longevity: A Systematic Review and Meta-Analysis

80/100 ✓ Peer-reviewed Genetics Rejuvenation Research

Key finding: The main result for all ethnic groups combined was that the likelihood of reaching EL was negatively associated with ε4 allele carriage [pooled odds ratio (OR)=0.43; 95% confidence interval (CI) 0.36, 0.50; p <0.001] and with ε4/ε4 (OR=0.18; 95% CI 0.08, 0.39; p <0.001), ε3/ε4 (OR=0.44; 95% CI 0.37, 0.53; p <0.001) and ε2/ε4 genotypes (OR=0.48; 95% CI 0.31, 0.74; p <0.001). +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Effects of metabolic syndrome on language functions in aging

38/100 ✓ Peer-reviewed Risk factors Journal of the International Neuropsychological Society : JINS

Key finding: MetS is a constellation of five vascular and metabolic risk factors associated with the development of chronic diseases and increased risk of mortality, as well as brain and cognitive impairments. +2 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease

45/100 ✓ Peer-reviewed Disease mechanisms Nature

Key finding: Our results reveal new insights into the mechanisms of neurodegeneration and establish the mouse as a useful model for functional studies of AD regulatory regions.

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Saxagliptin: a novel antiparkinsonian approach

36/100 ✓ Peer-reviewed Drug development Neuropharmacology

Key finding: Improvement in striatal energy level was associated with partial hindrance of ROT-induced body weight reduction. +2 more findings

Full summary, score breakdown and related studies → Original source

Evolution of prodromal clinical markers of Parkinson disease in a GBA mutation-positive cohort

43/100 ✓ Peer-reviewed Brain scans and imaging JAMA neurology

Key finding: This study indicates that, as a group, GBA mutation-positive individuals show a deterioration in clinical markers consistent with the prodrome of PD. +4 more findings

• Diagnosis
• Genetics

Full summary, score breakdown and related studies → Original source

B-lymphocyte-mediated delayed cognitive impairment following stroke

36/100 ✓ Peer-reviewed Vascular contributions The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: Each year, 10 million people worldwide survive the neurologic injury associated with a stroke. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Non-steroidal anti-inflammatory drugs as a treatment for Alzheimer's disease: a systematic review and meta-analysis of treatment effect

58/100 ✓ Peer-reviewed Cognitive tests and assessment Drugs & aging

Key finding: Alzheimer's disease (AD) is the cause of more than two-thirds of all dementia cases. +3 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Exendin-4, a glucagon-like peptide-1 receptor agonist, reduces Alzheimer disease-associated tau hyperphosphorylation in the hippocampus of rats with type 2 diabetes

39/100 ✓ Peer-reviewed Drug development Journal of investigative medicine : the official publication of the American Federation for Clinical Research

Key finding: Impaired insulin signaling pathway in the brain in type 2 diabetes (T2D) is a risk factor for Alzheimer disease (AD). +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Tau proteins in the temporal and frontal cortices in patients with vascular dementia

37/100 ✓ Peer-reviewed Tau biomarkers Journal of neuropathology and experimental neurology

Key finding: It is unclear, however, if tau proteins also accumulate in the brains of older VaD subjects. +3 more findings

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke

52/100 ✓ Peer-reviewed TREM2 and immune genetics The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: Triggering receptor expressed on myeloid cells-2 (TREM2) is a newly identified receptor expressed on microglia and is thought to phagocytose damaged brain cells. +3 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Downregulated miR-29c correlates with increased BACE1 expression in sporadic Alzheimer's disease

39/100 ✓ Peer-reviewed Risk genes beyond APOE International journal of clinical and experimental pathology

Key finding: Beta-site Amyloid precursor protein Cleaving Enzyme 1 (BACE1) is conceived as a potential target for therapies against Alzheimer disease (AD) which is characterized by the accumulation of plaques formed of short β-amyloid (APPβ) peptides. +3 more findings

Full summary, score breakdown and related studies → Original source

Parkinson's disease iron deposition caused by nitric oxide-induced loss of β-amyloid precursor protein

48/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: We reported previously that the Alzheimer-associated β-amyloid precursor protein (APP) facilitates neuronal iron export. +3 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Coding mutations in SORL1 and Alzheimer disease

52/100 ✓ Peer-reviewed Risk genes beyond APOE Annals of neurology

Key finding: Common single nucleotide polymorphisms in the SORL1 gene have been associated with late onset Alzheimer disease (LOAD), but causal variants have not been fully characterized nor has the mechanism been established. +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice

49/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: Klotho is a key modulator of the aging process and, when overexpressed, extends mammalian lifespan, increases synaptic plasticity, and enhances cognition. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source