Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 23,601–23,625 of 27,380 studies, newest first · page 945 of 1096.
July 2005 11
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2005-07-01
Brain-derived neurotrophic factor val66met polymorphism and volume of the hippocampal formation
47/100 ✓ Peer-reviewed Hippocampus size on brain scans Molecular psychiatry
Key finding: In this study, we investigated whether val66met, a functional and abundant missense polymorphism in the coding region of the BDNF gene, was associated with the volume of the hippocampal formation in 19 patients with first-episode schizophrenia and 25 healthy volunteers. +3 more findings
Full summary, score breakdown and related studies → Original source
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2005-07-01
Ways toward an early diagnosis in Alzheimer's disease: The Alzheimer's Disease Neuroimaging Initiative (ADNI)
54/100 ✓ Peer-reviewed Biomarkers Alzheimer s & Dementia
With the increasing life expectancy in developed countries, the incidence of Alzheimer's disease (AD) and thus its socioeconomic impact are growing.
Full summary, score breakdown and related studies → Original source
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2005-07-01
Early and late life cognitive activity and cognitive systems in old age
48/100 ✓ Peer-reviewed Brain tissue and pathology Journal of the International Neuropsychological Society : JINS
Key finding: In a cohort of 576 older persons without dementia, we assessed current and past (childhood, young adulthood, middle age) frequency of cognitive activity; availability of cognitively stimulating resources in the home in childhood and middle age; and 5 domains of cognitive function. +3 more findings
Full summary, score breakdown and related studies → Original source
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2005-07-01
Restrictions of the Mini-Mental State Examination in acute stroke
49/100 ✓ Peer-reviewed Cognitive tests and assessment Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists
Key finding: However, the validity of the MMSE as such has never been evaluated in acute stroke. +3 more findings
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2005-07-01
A total score for the CERAD neuropsychological battery
56/100 ✓ Peer-reviewed Cognitive tests and assessment Neurology
Key finding: CERAD total scores were obtained by summing scores from the individual CERAD subtests (excluding the Mini-Mental State Examination [MMSE]) into a total composite (maximum score = 100). +3 more findings
Full summary, score breakdown and related studies → Original source
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2005-07-01
Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer's disease
46/100 ✓ Peer-reviewed Mild cognitive impairment Neurobiology of aging
Key finding: Our data show that there is a statistically significant (P<0.05) increase in HNE in HPG, SMTG and CER in MCI compared to age-matched control subjects. +4 more findings
Full summary, score breakdown and related studies → Original source
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2005-07-01
Dementia and Alzheimer's disease incidence in relationship to cardiovascular disease in the Cardiovascular Health Study cohort
72/100 ✓ Peer-reviewed How common it is Journal of the American Geriatrics Society
Key finding: Older adults with CVD other than stroke had a higher risk of dementia and AD than did those without CVD. +4 more findings
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2005-07-01
Measuring atrophy in Alzheimer disease: a serial MRI study over 6 and 12 months
49/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: This potential benefit must be balanced against the possibility that ventricular volumes may be more likely to be affected by factors other than neurodegeneration.
Full summary, score breakdown and related studies → Original source
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2005-07-01
International conference on the healthy effect of virgin olive oil
39/100 ✓ Peer-reviewed Prevention and risk European journal of clinical investigation
Key finding: Epidemiological studies suggest that a Mediterranean diet (which is rich in virgin olive oil) decreases the risk of cardiovascular disease. 3. +3 more findings
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2005-07-01
Atorvastatin therapy lowers circulating cholesterol but not free radical activity in advance of identifiable clinical benefit in the treatment of mild-to-moderate AD
56/100 ✓ Peer-reviewed Treatments Current Alzheimer research
Key finding: Cholesterol-induced production of amyloid beta (Abeta) as a putative neurotoxin in Alzheimer's disease (AD), along with epidemiological evidence, suggests that statin drugs may provide benefit in treatment of the disorder. +4 more findings
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2005-07-01
APOE, vascular pathology, and the AD brain
47/100 ✓ Peer-reviewed Genetics Neurology
Key finding: APOE-epsilon4 is associated with small vessel arteriolosclerosis, microinfarcts of the deep nuclei, neuritic senile plaque density, and amyloid angiopathy in patients with autopsy-proven Alzheimer disease (AD). +4 more findings
Full summary, score breakdown and related studies → Original source
June 2005 14
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2005-06-29
Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice
50/100 ✓ Peer-reviewed Down syndrome and Alzheimer's The Journal of biological chemistry
Key finding: A variable but significant number of BACE1 offspring died in the first weeks after birth. +4 more findings
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2005-06-27
The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production
45/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: Amyloid is mainly composed by amyloid-beta (A(beta)) peptides, which are derive from processing of the beta-amyloid precursor protein (APP), better named amyloid-beta precursor protein (A(beta)PP), by secretases. +3 more findings
Full summary, score breakdown and related studies → Original source
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2005-06-21
National Institutes of Health State-of-the-Science Conference Statement: Management of Menopause-Related Symptoms
53/100 ✓ Peer-reviewed Disparities Annals of Internal Medicine
Key finding: NIH Conferences21 June 2005National Institutes of Health State-of-the-Science Conference Statement: Management of Menopause-Related SymptomsFREENIH State-of-the-Science Panel*NIH State-of-the-Science Panel*Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-142-12_Part_1-200506210-00117 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail National Institutes of Health (NIH) consensus and state-of-the-science statements are prepared by independent panels of health professionals and public representatives on the basis of 1) the results of a systematic literature review prepared under contract with the Agency for Healthcare Research and Quality (AHRQ), 2) presentations by investigators working in areas relevant to the conference questions during a 2-day public session, 3) questions and statements from conference attendees during open discussion periods that are part of the public session, and 4) closed deliberations by the panel during the remainder of the second day and the morning of the third. +4 more findings
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2005-06-21
Attitudes of physicians, nurses and relatives towards end-of-life decisions concerning nursing home patients with dementia
36/100 ✓ Peer-reviewed End-of-life care Patient education and counseling
Key finding: Although physicians, nurses and relatives are all guided by the best interest of the patient, it seems that differences in religious beliefs, perspective of the patient, and responsibility can lead to different attitudes towards end-of-life decisions.
Full summary, score breakdown and related studies → Original source
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2005-06-18
Donepezil for dementia in Parkinson's disease: a randomised, double blind, placebo controlled, crossover study
57/100 ✓ Peer-reviewed Treatments Journal of Neurology Neurosurgery & Psychiatry
Key finding: Donepezil was well tolerated and most adverse events were mild. +4 more findings
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2005-06-16
Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype
41/100 ✓ Peer-reviewed Genetics Neurobiology of aging
Key finding: These findings suggest that intranasal insulin administration may have therapeutic benefit without the risk of peripheral hypoglycemia and provide further evidence for apolipoprotein E (APOE) related differences in insulin metabolism.
Full summary, score breakdown and related studies → Original source
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2005-06-13
Management of referred deep brain stimulation failures: a retrospective analysis from 2 movement disorders centers
38/100 ✓ Peer-reviewed Treatments Archives of neurology
Key finding: An increasing number of patients come to experienced DBS centers after unsatisfactory results from DBS surgery. +4 more findings
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2005-06-13
Oxidative modification and down-regulation of Pin1 in Alzheimer's disease hippocampus: A redox proteomics analysis
50/100 ✓ Peer-reviewed Risk genes beyond APOE Neurobiology of aging
Key finding: AD brain has been reported to be under oxidative stress that may play an important role in the pathogenesis and progression of AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2005-06-09
Cerebral small-vessel disease and decline in information processing speed, executive function and memory
48/100 ✓ Peer-reviewed Vascular contributions Brain : a journal of neurology
Key finding: Increasing severity of periventricular WML and generalized brain atrophy and the presence of brain infarcts on MRI were associated with a steeper decline in cognitive function. +4 more findings
Full summary, score breakdown and related studies → Original source
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2005-06-09
Kinetic Modeling of Amyloid Binding in Humans using PET Imaging and Pittsburgh Compound-B
46/100 ✓ Peer-reviewed Brain scans and imaging Journal of Cerebral Blood Flow & Metabolism
A valid quantitative imaging method for the measurement of amyloid deposition in humans could improve Alzheimer's disease (AD) diagnosis and antiamyloid therapy assessment.
Full summary, score breakdown and related studies → Original source
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2005-06-09
Obesity in middle age and future risk of dementia: a 27 year longitudinal population based study
68/100 ✓ Peer-reviewed Prevention and risk BMJ
Key finding: Obese people in midlife (BMI 30+) had 74% higher dementia risk decades later than normal-weight peers +3 more findings
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2005-06-02
Correlations between apolipoprotein E epsilon4 gene dose and brain-imaging measurements of regional hypometabolism
52/100 ✓ Peer-reviewed Brain tissue and pathology Proceedings of the National Academy of Sciences of the United States of America
Key finding: Apolipoprotein E (APOE) epsilon4 gene dose (i.e., the number of epsilon4 alleles in a person's APOE genotype) is associated with a higher risk of AD and a younger age at dementia onset. +3 more findings
Full summary, score breakdown and related studies → Original source
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2005-06-01
The impact of long-chainn-3 polyunsaturated fatty acids on human health
40/100 ✓ Peer-reviewed Brain scans and imaging Nutrition Research Reviews
Key finding: Data from intervention trials are consistent in suggesting that LC n-3 PUFA lower the risk of CVD, probably by the multiple mechanisms of lowering serum triacylglycerols, improving the LDL:HDL ratio, anti-arrhythmic effects on heart muscle, improved plaque stability, anti-thrombotic effects and reduced endothelial activation.
Full summary, score breakdown and related studies → Original source
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2005-06-01
Diagnosis and management of idiopathic normal-pressure hydrocephalus: a prospective study in 151 patients
41/100 ✓ Peer-reviewed Digital health tools Journal of neurosurgery
Key finding: The clinical criterion for idiopathic NPH included ventriculomegaly demonstrated on computerized tomography or magnetic resonance imaging studies combined with gait disturbance, incontinence, and dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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