Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 22,851–22,875 of 27,380 studies, newest first · page 915 of 1096.
December 2006 17
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2006-12-01
Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans
36/100 ✓ Peer-reviewed Disease mechanisms The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: We previously demonstrated that the standardized Ginkgo biloba extract EGb 761, commonly used to enhance memory and by AD patients for dementia, inhibits Abeta-induced apoptosis in neuroblastoma cells. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-12-01
Green Banana*: Dementia Epidemiology Research: It Is Time to Modify the Focus of Research
41/100 ✓ Peer-reviewed Risk factors The Journals of Gerontology Series A
Key finding: Study designs need to be modified, including a greater emphasis on geographic variations in AD and dementia based on imaging studies, longitudinal studies of successful aging without cardiovascular disease (CVD) or AD, gene-environment interactions, and studies of unique populations that may be at lower risk because of specific lifestyles.
Full summary, score breakdown and related studies → Original source
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2006-12-01
Assembly Votes Challenge Threats to Patient Care
22/100 ✓ Peer-reviewed Health systems and care delivery Psychiatric News
Key finding: Back to table of contents Previous article Next article Association NewsFull AccessAssembly Votes Challenge Threats to Patient CareKen HausmanKen HausmanSearch for more papers by this authorPublished Online:1 Dec 2006https://doi.org/10.1176/pn.41.23.0004Patient care issues had a prominent place on the agenda for the APA Assembly's November meeting in Washington, D.C., and several dealt with prescribing concerns in a health care environment that is not always patient friendly.
Full summary, score breakdown and related studies → Original source
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2006-12-01
Cognitive impact of subcortical vascular and Alzheimer's disease pathology
63/100 ✓ Peer-reviewed Brain tissue and pathology Annals of neurology
Key finding: Thirty percent of the cases had significant cerebrovascular parenchymal pathology scores (CVDPS), 54% had significant AD pathology, and 18% had HS. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-12-01
Patient versus informant reported quality of life in the earliest phases of Alzheimer's disease
43/100 ✓ Peer-reviewed Cognitive tests and assessment International journal of geriatric psychiatry
Key finding: In addition, we examined whether anosognosia had an impact on the agreement between patient and informant ratings of QoL and whether anosognosia, dementia severity, depression and behavioural symptoms were significantly correlated to QoL in early AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-12-01
Stanley Fahn Lecture 2005: The staging procedure for the inclusion body pathology associated with sporadic Parkinson's disease reconsidered
53/100 ✓ Peer-reviewed Lewy body dementia Movement disorders : official journal of the Movement Disorder Society
Key finding: A recent staging procedure for the inclusion body pathology associated with PD proposes that, in the brain, the pathological process (formation of proteinaceous intraneuronal Lewy bodies and Lewy neurites) begins at two sites and continues in a topographically predictable sequence in six stages, during which components of the olfactory, autonomic, limbic, and somatomotor systems become progressively involved.
Full summary, score breakdown and related studies → Original source
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2006-12-01
Progressive increase of frontostriatal brain activation from childhood to adulthood during event-related tasks of cognitive control
47/100 ✓ Peer-reviewed Lewy body dementia Human brain mapping
Key finding: Adults compared with children showed increased brain activation in task-specific frontostriatal networks, including right orbital and mesial prefrontal cortex and caudate during the Go/no-go task, right mesial and inferior prefrontal cortex, parietal lobe, and putamen during the Switch task and left dorsolateral and inferior frontotemporoparietal regions and putamen during the Simon task.
Full summary, score breakdown and related studies → Original source
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2006-12-01
Beta-amyloid, oxidative stress and down syndrome
39/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Current Alzheimer research
Key finding: Overexpression of APP in the obligate region for DS is associated with abundant Abeta plaques and tangles consistent with Braak stage V-VI. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-12-01
Omega-3 fatty acids: evidence basis for treatment and future research in psychiatry
65/100 ✓ Peer-reviewed How common it is The Journal of clinical psychiatry
Key finding: The preponderance of epidemiologic and tissue compositional studies supports a protective effect of omega-3 EFA intake, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in mood disorders. +2 more findings
Full summary, score breakdown and related studies → Original source
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2006-12-01
Feasibility of telecognitive assessment in dementia
44/100 ✓ Peer-reviewed Disparities Assessment
Key finding: VC-based diagnostic interviewing has shown good agreement with conventional face-to-face diagnosis of dementia in several investigations, but extension of this technology to neurocognitive assessment has received little attention. +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-12-01
Diabetes is related to cerebral infarction but not to AD pathology in older persons
50/100 ✓ Peer-reviewed Caregiving Neurology
Key finding: Subjects were 233 older Catholic clergy in the Religious Orders Study, who underwent detailed annual evaluations, including neuropsychological testing, and brain autopsy at time of death (mean age 86 years, 45% men). +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-12-01
Brain metal concentrations in chronic liver failure patients with pallidal T1 MRI hyperintensity
43/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: In chronic liver failure, manganese accumulation is responsible for the pallidal MRI T1 hyperintensity. +2 more findings
Full summary, score breakdown and related studies → Original source
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2006-12-01
Extent and distribution of white matter hyperintensities in normal aging, MCI, and AD
56/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: Differences in white matter hyperintensities (WMH) associated with increasing cognitive impairment appear related to both extent and spatial location. +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-12-01
Vitamin D deficiency is associated with low mood and worse cognitive performance in older adults
56/100 ✓ Peer-reviewed Getting a diagnosis The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: In a cross-section of older adults, vitamin D deficiency was associated with low mood and with impairment on two of four measures of cognitive performance. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-12-01
Mild cognitive impairment: long-term course of four clinical subtypes
69/100 ✓ Peer-reviewed Getting a diagnosis Neurology
Key finding: It has been assumed that each MCI subtype is associated with an increased risk for a particular type of dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-12-01
High-sensitivity C-reactive protein and risk of nontraumatic fractures in the Bruneck study
51/100 ✓ Peer-reviewed Prevention and risk Archives of internal medicine
Key finding: Between September 1, 1990, and August 31, 2005, 69 subjects experienced nontraumatic hip or vertebral fractures. +2 more findings
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2006-12-01
Survival and mortality differences between dementia with Lewy bodies vs Alzheimer disease
62/100 ✓ Peer-reviewed Genetics Neurology
Key finding: Patients with DLB had an increased risk of mortality vs patients with AD (hazard ratio [HR] 1.88, 95% CI: 1.4 to 2.5). +2 more findings
Full summary, score breakdown and related studies → Original source
November 2006 8
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2006-11-29
The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease
49/100 ✓ Peer-reviewed Genetics Human molecular genetics
Key finding: We scanned throughout chromosome 21 to assess genetic associations with late-onset Alzheimer disease (AD) using 374 Japanese patients and 375 population-based controls, because trisomy 21 is known to be associated with early deposition of beta-amyloid (Abeta) in the brain. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-11-27
Bilingualism as a protection against the onset of symptoms of dementia
54/100 ✓ Peer-reviewed Getting a diagnosis Neuropsychologia
Key finding: This study examined the effect of lifelong bilingualism on maintaining cognitive functioning and delaying the onset of symptoms of dementia in old age. +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-11-22
Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression
36/100 ✓ Peer-reviewed Vascular contributions Proceedings of the National Academy of Sciences of the United States of America
Key finding: A history of stroke was found to be associated with development of some AD cases, especially in the presence of vascular risk factors. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-11-21
Hippocampal volume is as variable in young as in older adults: implications for the notion of hippocampal atrophy in humans
64/100 ✓ Peer-reviewed Hippocampus size on brain scans NeuroImage
Key finding: Altogether, these data suggested that aging or psychiatric disease can have neurotoxic effects on the hippocampus, and lead to HC atrophy. +2 more findings
Full summary, score breakdown and related studies → Original source
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2006-11-21
Enhancing the Quality of Life of Dementia Caregivers From Different Ethnic or Racial Groups: A Randomized, Controlled Trial
71/100 ✓ Peer-reviewed Caregiving Annals of Internal Medicine
Key finding: 212 Hispanic/Latino, 219 White, and 211 Black/African-American caregiver-care recipient pairs were randomized +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-11-19
Activation of beta2-adrenergic receptor stimulates gamma-secretase activity and accelerates amyloid plaque formation
50/100 ✓ Peer-reviewed Brain tissue and pathology Nature medicine
Key finding: Mutations of presenilin-1, the gamma-secretase catalytic subunit, can affect amyloid-beta (Abeta) production and Alzheimer disease pathogenesis. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-11-17
Community based occupational therapy for patients with dementia and their care givers: randomised controlled trial
76/100 ✓ Peer-reviewed Caregiving BMJ (Clinical research ed.)
Key finding: Occupational therapy improved patients' daily functioning and reduced the burden on the care giver, despite the patients' limited learning ability. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-11-17
Cardiovascular and cerebrovascular events in the randomized, controlled Alzheimer's Disease Anti-Inflammatory Prevention Trial (ADAPT)
55/100 ✓ Peer-reviewed Prevention and risk PLoS clinical trials
Key finding: For celecoxib, ADAPT data do not show the same level of risk as those of the APC trial.
Full summary, score breakdown and related studies → Original source
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