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Relationship between serum insulin-like growth factor-1 levels and Alzheimer's disease and vascular dementia
Watanabe T, Miyazaki A, Katagiri T, Yamamoto H, Idei T, Iguchi T.. Journal of the American Geriatrics Society, 2005-10-01
Topic: Amyloid, tau and blood-test diagnosis
Objectives To determine whether decreased serum insulin-like growth factor-1 (IGF-1) levels could be a risk factor for dementia in older people. Setting Showa University Karasuyama Hospital, Tokyo, Japan. Participants A total of 436 Japanese elderly subjects: 106 patients with Alzheimer's disease (AD), 103 patients with vascular dementia (VaD), and 227 age-matched controls without dementia.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Watanabe, T., Miyazaki, A., Katagiri, T., Yamamoto, H., Idei, T., & Iguchi, T. (2005). Relationship between serum insulin-like growth factor-1 levels and Alzheimer's disease and vascular dementia. Journal of the American Geriatrics Society. https://doi.org/10.1111/j.1532-5415.2005.53524.x
Vancouver
Watanabe T, Miyazaki A, Katagiri T, Yamamoto H, Idei T, Iguchi T. Relationship between serum insulin-like growth factor-1 levels and Alzheimer's disease and vascular dementia. Journal of the American Geriatrics Society. 2005. doi:10.1111/j.1532-5415.2005.53524.x. PMID: 16181175.
BibTeX
@article{watanabe2005-16181175,
author = {Watanabe, T. and Miyazaki, A. and Katagiri, T. and Yamamoto, H. and Idei, T. and Iguchi, T.},
title = {{Relationship between serum insulin-like growth factor-1 levels and Alzheimer's disease and vascular dementia}},
journal = {Journal of the American Geriatrics Society},
year = {2005},
doi = {10.1111/j.1532-5415.2005.53524.x},
pmid = {16181175},
url = {https://doi.org/10.1111/j.1532-5415.2005.53524.x}
}
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Key findings
- Setting Showa University Karasuyama Hospital, Tokyo, Japan.
- Participants A total of 436 Japanese elderly subjects: 106 patients with Alzheimer's disease (AD), 103 patients with vascular dementia (VaD), and 227 age-matched controls without dementia.
- Measurements Serum concentrations of IGF-1 and atherogenic lipoproteins, carotid artery intima-media thickness (IMT), and plaques were determined.
- Results Mini-Mental State Examination (MMSE) scores were positively correlated with serum IGF-1 concentrations as well as mean blood pressure or body mass index and were negatively correlated with age, serum low-density lipoprotein cholesterol and lipoprotein(a) concentrations, and carotid IMT.
Why it matters
This study of 436 elderly subjects examined whether lower serum insulin-like growth factor-1 levels were a risk factor for Alzheimer's disease and vascular dementia, finding MMSE scores positively correlated with serum IGF-1. This describes an association between IGF-1 levels and cognition, but it does not show that altering IGF-1 treats or prevents dementia.
Study details
- Participants106
- Evidence strengthLow
How this study scored 45/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 43 of the 96 points we could judge it on, which is 45 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of the American Geriatrics Society) |
| Journal's citation record | 3 / 4 | Journal of the American Geriatrics Society: journal h-index 344 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2005 — older than 20 years, still counted |
| Sample size | 2 / 4 | 106 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 133 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 5.8 citations a year over 23 year(s) since 2005 |
| Impact for its field and year | 3 / 6 | Cited 3.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 3 other studies in this library |
| Still being cited | 1 / 4 | Cited 11 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | 0 / 3 | SHOWA Medical University: institution h-index 420 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 16181175) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 43 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 43 of the 96 points we could judge it on is 45 out of 100. |
| Total | 45 / 100 | — |
What each of these 20 components measures, and what this score is not →
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