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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 10,976–11,000 of 27,380 studies, newest first · page 440 of 1096.

November 2020 25

  1. 2020-11-11

    White matter hyperintensities and risks of cognitive impairment and dementia: A systematic review and meta-analysis of 36 prospective studies

    ✓ Peer-reviewed Vascular contributions Neuroscience and biobehavioral reviews

    Key finding: WMH were associated with increased risk of cognitive dysfunction and could become a neuroimaging indicator of dementia. +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2020-11-11

    Antibiotic use during end-of-life care: A systematic literature review and meta-analysis

    ✓ Peer-reviewed End-of-life care Infection control and hospital epidemiology

    Key finding: Future studies are needed to evaluate the benefits and harms of using antibiotics for patients during EOL care in diverse patient populations. +2 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2020-11-11

    TDP-43 proteinopathies: a new wave of neurodegenerative diseases

    ✓ Peer-reviewed Lewy body dementia Journal of neurology, neurosurgery, and psychiatry

    Key finding: This review highlights the key physiological functions of the TDP-43 protein, while considering an expanding spectrum of neurodegenerative diseases associated with pathogenic TDP-43 deposition, and dissecting key molecular pathways through which TDP-43 may mediate neurodegeneration.

    Full summary, score breakdown and related studies → Original source

  4. 2020-11-10

    Combination of snapshot hyperspectral retinal imaging and optical coherence tomography to identify Alzheimer's disease patients

    ✓ Peer-reviewed Brain scans and imaging Alzheimer's research & therapy

    Key finding: Hyperspectral data and retinal nerve fiber layer thickness data were used in a linear discriminant classification model to discriminate between AD patients and controls. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2020-11-10

    Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer's continuum when only subtle changes in Aβ pathology are detected

    ✓ Peer-reviewed Tau biomarkers EMBO molecular medicine

    Key finding: The main aim of our study was to characterize the pattern of changes in phosphorylated tau (p-tau) in the preclinical stage of the Alzheimer's continuum. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2020-11-10

    A novel systems biology approach to evaluate mouse models of late-onset Alzheimer's disease

    ✓ Peer-reviewed TREM2 and immune genetics Molecular neurodegeneration

    Key finding: Late-onset Alzheimer's disease (LOAD) is the most common form of dementia worldwide. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2020-11-10

    Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis

    ✓ Peer-reviewed Genetics Neuron

    Key finding: Apolipoprotein E (ApoE) is of great interest due to its role as a cholesterol/lipid transporter in the central nervous system (CNS) and as the most influential genetic risk factor for Alzheimer disease (AD). +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2020-11-09

    Emerging potential of cannabidiol in reversing proteinopathies

    ✓ Peer-reviewed Disease mechanisms Ageing research reviews

    Key finding: Over the past years, compelling evidence has documented disease-modifying role of CBD in various preclinical and clinical models of neurological disorders, suggesting the potential therapeutic implications of CBD in these disorders. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2020-11-09

    The NLRP3 inflammasome triggers sterile neuroinflammation and Alzheimer's disease

    ✓ Peer-reviewed Inflammation and the immune system Current opinion in immunology

    Key finding: The NLRP3 inflammasome coordinates such processes to clear tissue damage and induce repair. +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2020-11-09

    PINK1/PARKIN signalling in neurodegeneration and neuroinflammation

    ✓ Peer-reviewed Brain scans and imaging Acta neuropathologica communications

    Key finding: Mutations in the PTEN-induced kinase 1 (PINK1) and Parkin RBR E3 ubiquitin-protein ligase (PARKIN) genes are associated with familial forms of Parkinson's disease (PD).

    Full summary, score breakdown and related studies → Original source

  11. 2020-11-09

    Bidirectional associations between COVID-19 and psychiatric disorder: retrospective cohort studies of 62 354 COVID-19 cases in the USA

    ✓ Peer-reviewed Getting a diagnosis The lancet. Psychiatry

    Key finding: Although preliminary, our findings have implications for clinical services, and prospective cohort studies are warranted. +2 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2020-11-07

    Alzheimer-related altered white matter microstructural integrity in Down syndrome: A model for sporadic AD?

    ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer's & dementia (Amsterdam, Netherlands)

    Key finding: Our findings suggest that quantification of WM changes in DS could provide a promising and clinically relevant biomarker for AD clinical onset and progression. +1 more finding

    Full summary, score breakdown and related studies → Original source

  13. 2020-11-07

    Socioeconomic Status Mediates Racial Differences Seen Using the AT(N) Framework

    ✓ Peer-reviewed Disparities Annals of neurology

    Key finding: Future studies should emphasize collection of relevant psychosocial factors in addition to the development of intentional diversity and inclusion efforts to improve the racial/ethnic and socioeconomic representativeness of AD studies.

    Full summary, score breakdown and related studies → Original source

  14. 2020-11-06

    The dietary fatty acids α-linolenic acid (ALA) and linoleic acid (LA) selectively inhibit microglial nitric oxide production

    ✓ Peer-reviewed Prevention trials Molecular and cellular neurosciences

    Key finding: Furthermore, gas chromatography with a flame ionization detector (GC-FID) revealed that exposure to LA or ALA did not alter the fatty acid composition of BV-2 microglia. +1 more finding

    Full summary, score breakdown and related studies → Original source

  15. 2020-11-06

    Novel benzoic acid derivatives: Synthesis and biological evaluation as multitarget acetylcholinesterase and carbonic anhydrase inhibitors

    ✓ Peer-reviewed Digital health tools Archiv der Pharmazie

    Key finding: The results revealed that 6c (1,3-dimethyldihydropyrimidine-2,4-(1H,3H)-dione-substituted, K I value of 33.00 ± 0.29 nM), 6e (cyclohexanone-substituted, K I value of 18.78 ± 0.09 nM), and 6f (2,2-dimethyl-1,3-dioxan-4-one-substituted, K I value of 13.62 ± 0.21 nM) from the benzoic acid derivatives in this series were the most promising derivatives, as they exhibited a good multifunctional inhibition at all experimental levels and in the in silico validation against hCA I, hCA II, and AChE, respectively, for the treatment of AD.

    Full summary, score breakdown and related studies → Original source

  16. 2020-11-05

    scREAD: A Single-Cell RNA-Seq Database for Alzheimer's Disease

    ✓ Peer-reviewed Genetics iScience

    Key finding: The single-cell RNA-sequencing (scRNA-Seq) and single-nucleus RNA-sequencing (snRNA-Seq) techniques are extremely useful for dissecting the function/dysfunction of highly heterogeneous cells in the brain at the single-cell level, and the corresponding data analyses can significantly improve our understanding of why particular cells are vulnerable in AD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  17. 2020-11-05

    Comparing cortical signatures of atrophy between late-onset and autosomal dominant Alzheimer disease

    ✓ Peer-reviewed Biomarkers NeuroImage. Clinical

    Key finding: Defining a signature of cortical regions of interest preferentially affected by Alzheimer disease (AD) pathology may offer improved sensitivity to early AD compared to hippocampal volume or mesial temporal lobe alone. +2 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2020-11-04

    APOE2: protective mechanism and therapeutic implications for Alzheimer's disease

    ✓ Peer-reviewed Genetics Molecular neurodegeneration

    Key finding: Investigations of apolipoprotein E (APOE) gene, the major genetic risk modifier for Alzheimer's disease (AD), have yielded significant insights into the pathogenic mechanism. +3 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2020-11-04

    Comparison of Common and Disease-Specific Post-translational Modifications of Pathological Tau Associated With a Wide Range of Tauopathies

    ✓ Peer-reviewed Disease mechanisms Frontiers in neuroscience

    Key finding: In pathological tau proteins associated with a wide range of tauopathies, 170 PTMs in total were identified including new PTMs. +1 more finding

    Full summary, score breakdown and related studies → Original source

  20. 2020-11-04

    Vitamin D exerts neuroprotection via SIRT1/nrf-2/ NF-kB signaling pathways against D-galactose-induced memory impairment in adult mice

    ✓ Peer-reviewed Disease mechanisms Neurochemistry international

    Key finding: D plays a significant part in memory and cognition as its inadequate amount may accelerate cognitive impairment. +3 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2020-11-03

    Social Frailty in the COVID-19 Pandemic Era

    ✓ Peer-reviewed Risk factors Frontiers in psychiatry

    Key finding: Frailty is an age-related multidimensional clinical condition defined as a non-specific state of vulnerability, identifying older people at increased risk of falls, institutionalization, hospitalization, disability, dementia, and death. +1 more finding

    Full summary, score breakdown and related studies → Original source

  22. 2020-11-03

    Apolipoprotein E (APOE) ε4 Status Moderates the Relationship Between Close-Range Blast Exposure and Cognitive Functioning

    ✓ Peer-reviewed Genetics Journal of the International Neuropsychological Society : JINS

    Key finding: As predicted, we observed a differential impact of CBE status on cognition as a function of APOE ε4 status, in which CBE ε4 carriers displayed significantly worse neuropsychological performance, specifically in the domain of memory. +2 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2020-11-03

    Hi-GCN: A hierarchical graph convolution network for graph embedding learning of brain network and brain disorders prediction

    ✓ Peer-reviewed Digital health tools Computers in biology and medicine

    Key finding: The proposed hi-GCN method performs the graph embedding learning from a hierarchical perspective while considering the structure in individual brain network and the subject's correlation in the global population network, which can capture the most essential embedding features to improve the classification performance of disease diagnosis. +1 more finding

    Full summary, score breakdown and related studies → Original source

  24. 2020-11-02

    Loss of TREM2 Confers Resilience to Synaptic and Cognitive Impairment in Aged Mice

    ✓ Peer-reviewed TREM2 and immune genetics The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: Human genetic studies have shown that the loss-of-function mutations in TREM2 signaling are strongly associated with an elevated risk of age-related neurodegenerative diseases including Alzheimer's disease (AD). +3 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2020-11-02

    APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids

    ✓ Peer-reviewed Risk factors Nature communications

    Key finding: APOE4 is the strongest genetic risk factor associated with late-onset Alzheimer's disease (AD). +2 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →