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Atherosclerosis and risk for dementia
van Oijen M, de Jong FJ, Witteman JC, Hofman A, Koudstaal PJ, Breteler MM.. Annals of neurology, 2007-05-01
Topic: Risk, prevention and care in population studies
Objective Atherosclerosis has been implicated in the development of dementia and its major subtypes, Alzheimer's disease and vascular dementia. However, support for this association mainly comes from cross-sectional studies. We investigated the association of atherosclerosis with dementia and subtypes of dementia during long follow-up, with various noninvasive measures of atherosclerosis.
Key findings
- However, support for this association mainly comes from cross-sectional studies.
- We investigated the association of atherosclerosis with dementia and subtypes of dementia during long follow-up, with various noninvasive measures of atherosclerosis.
- Methods This study was based on 6,647 participants in the Rotterdam Study, a population-based prospective cohort study among 7,983 elderly subjects.
- At baseline (1990-1993) and at the third survey (1997-1999), common carotid intima media thickness, carotid plaques, and peripheral arterial disease (measured as ankle-brachial index) were measured.
Why it matters
This study investigated whether atherosclerosis, or hardening of the arteries, is linked to dementia and its subtypes over long follow-up in 6,647 participants. It examined a possible risk factor for dementia, which could inform prevention efforts, but no treatment was tested.
Study details
- Study designcohort study
- Participants6,647
- Evidence strengthModerate
How this study scored 64/100
Published in a leading specialty journal, and it is a cohort study following people over time. Scored zero for effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Annals of neurology) |
| Journal's citation record | 3 / 4 | Annals of Neurology: journal h-index 437 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2007 — within 20 year(s) of the newest study here |
| Sample size | 3 / 4 | 6,647 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 312 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 14.9 citations a year over 21 year(s) since 2007 |
| Impact for its field and year | 4 / 6 | Cited 11.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 19 other studies in this library |
| Still being cited | 2 / 4 | Cited 29 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Monique M.B. Breteler: h-index 162 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Erasmus MC: institution h-index 1,321 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 17328068) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 64 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
van Oijen, M., de Jong, F. J., Witteman, J. C., Hofman, A., Koudstaal, P. J., & Breteler, M. M. (2007). Atherosclerosis and risk for dementia. Annals of neurology. https://doi.org/10.1002/ana.21073
Vancouver
van Oijen M, de Jong FJ, Witteman JC, Hofman A, Koudstaal PJ, Breteler MM. Atherosclerosis and risk for dementia. Annals of neurology. 2007. doi:10.1002/ana.21073. PMID: 17328068.
BibTeX
@article{vanoijen2007-17328068,
author = {van Oijen, M. and de Jong, F. J. and Witteman, J. C. and Hofman, A. and Koudstaal, P. J. and Breteler, M. M.},
title = {{Atherosclerosis and risk for dementia}},
journal = {Annals of neurology},
year = {2007},
doi = {10.1002/ana.21073},
pmid = {17328068},
url = {https://doi.org/10.1002/ana.21073}
}
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