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CIND and MCI in the Italian elderly: frequency, vascular risk factors, progression to dementia
Di Carlo A, Lamassa M, Baldereschi M, Inzitari M, Scafato E, Farchi G, Inzitari D.. Neurology, 2007-05-01
Topic: Risk, prevention and care in population studies
Objective To estimate prevalence and progression to dementia of cognitive impairment, no dementia (CIND), mild cognitive impairment (MCI), and relative subtypes, evaluating the relationships with daily functioning, cardiovascular diseases and vascular risk factors. Methods We evaluated CIND and MCI in the Italian Longitudinal Study on Aging. The neuropsychological battery assessed global cognitive function, memory and attention. Two thousand eight hundred thirty participants were examined at baseline and after a mean follow-up of 3.9 +/- 0.7 years. Results The prevalence was 9.5% for CIND and 16.1% for MCI. Prevalence rates for CIND subtypes were 1.8% for amnestic, 2.3% for single nonmemory, 1.5% for multidomain, and 3.9% for CIND defined only on global cognitive function. The prevalence was 7.0% for amnestic, 7.8% for single nonmemory, and 1.3% for multidomain MCI. Incidence of dementia (per 1,000 person-years) was 7.63 in the total sample, 21.37 in CIND, and 13.59 in MCI. In MCI, rates ranged from 8.74 in amnestic to 40.60 in multidomain subtype. The highest incidence of 56.02 per 1,000 person-years was found in multidomain CIND. Both CIND and MCI increased by almost three times the risk of dementia at follow-up. Among baseline variables, only previous stroke and impairment in instrumental activities of daily living significantly increased the risk of dementia at follow-up. Conclusions Both cognitive impairment, no dementia and mild cognitive impairment are frequent in the Italian elderly (2,955,000 prevalent cases expected) and significantly predict progression to dementia. Individuation of subgroups with different risk factors and transition rates to dementia is required to plan early and cost-effective interventions.
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APA 7th
Di Carlo, A., Lamassa, M., Baldereschi, M., Inzitari, M., Scafato, E., Farchi, G., et al. (2007). CIND and MCI in the Italian elderly: frequency, vascular risk factors, progression to dementia. Neurology. https://doi.org/10.1212/01.wnl.0000263132.99055.0d
Vancouver
Di Carlo A, Lamassa M, Baldereschi M, Inzitari M, Scafato E, Farchi G, et al. CIND and MCI in the Italian elderly: frequency, vascular risk factors, progression to dementia. Neurology. 2007. doi:10.1212/01.wnl.0000263132.99055.0d. PMID: 17536047.
BibTeX
@article{dicarlo2007-17536047,
author = {Di Carlo, A. and Lamassa, M. and Baldereschi, M. and Inzitari, M. and Scafato, E. and Farchi, G. and Inzitari, D.},
title = {{CIND and MCI in the Italian elderly: frequency, vascular risk factors, progression to dementia}},
journal = {Neurology},
year = {2007},
doi = {10.1212/01.wnl.0000263132.99055.0d},
pmid = {17536047},
url = {https://doi.org/10.1212/01.wnl.0000263132.99055.0d}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Results The prevalence was 9.5% for CIND and 16.1% for MCI.
- Among baseline variables, only previous stroke and impairment in instrumental activities of daily living significantly increased the risk of dementia at follow-up.
- Conclusions Both cognitive impairment, no dementia and mild cognitive impairment are frequent in the Italian elderly (2,955,000 prevalent cases expected) and significantly predict progression to dementia.
Why it matters
This longitudinal study in Italian elderly people estimated the frequency of cognitive impairment, no dementia and mild cognitive impairment, and their progression to dementia. It found that both conditions significantly predicted progression to dementia, and that previous stroke and impairment in daily activities increased the risk.
Study details
- Study designlongitudinal study
- Effect size9.5%; 16.1%; 1.8%
- Evidence strengthModerate
How this study scored 58/100
Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for sample size, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2007 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 148 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 7.0 citations a year over 21 year(s) since 2007 |
| Impact for its field and year | 3 / 6 | Cited 4.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 15 other studies in this library |
| Still being cited | 1 / 4 | Cited 14 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Domenico Inzitari: h-index 60 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | National Research Council: institution h-index 840 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 17536047) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 58 / 100 | — |
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