Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 23,851–23,875 of 27,380 studies, newest first · page 955 of 1096.

December 2004 25

  1. 2004-12-01
  2. 2004-12-01

    The epidemiology of the comorbidity of epilepsy in the general population

    ✓ Peer-reviewed Getting a diagnosis Epilepsia

    Key finding: The prevalence ratio of many common psychiatric and somatic conditions is increased in adults with epilepsy who consult a primary care physician in the U.K. These findings may have implications in the diagnosis and management of epilepsy and coexisting conditions, as well as in health care provision. +2 more findings

  3. 2004-12-01

    Social resources and cognitive decline in a population of older African Americans and whites

    ✓ Peer-reviewed Prevention trials Neurology

    Key finding: Greater social resources, as defined by social networks and social engagement, are associated with reduced cognitive decline in old age. +3 more findings

  4. 2004-12-01

    Induction of hyperphosphorylated tau in primary rat cortical neuron cultures mediated by oxidative stress and glycogen synthase kinase-3

    ✓ Peer-reviewed Drug development Journal of Alzheimer's disease : JAD

    Key finding: Here we report that treatment of primary rat cortical neuron cultures with cuprizone, a copper chelator, in combination with oxidative stress (Fe(2+)/H(2)O(2)), significantly increased aberrant tau phosphorylation identified by TG3 immunochemistry. +2 more findings

  5. 2004-12-01

    Benefits of cognitive-motor intervention in MCI and mild to moderate Alzheimer disease

    ✓ Peer-reviewed Treatments Neurology

    Key finding: A long-term CMI in ChEI-treated early Alzheimer disease patients produced additional mood and cognitive benefits.

  6. 2004-12-01

    New therapeutic strategies and drug candidates for neurodegenerative diseases: p53 and TNF-alpha inhibitors, and GLP-1 receptor agonists

    ✓ Peer-reviewed Drug development Annals of the New York Academy of Sciences

    Key finding: Stimulation of the glucagon-like peptide-1 receptor (GLP-1R) in brain is associated with neurotrophic functions that, additionally, can protect cells against excess glutamate and other toxic insults.

  7. 2004-12-01

    Hippocampal volume in adult burn patients with and without posttraumatic stress disorder

    ✓ Peer-reviewed Hippocampus size on brain scans The American journal of psychiatry

    Key finding: PTSD is not a necessary condition for small hippocampal size in trauma-exposed individuals. +4 more findings

  8. 2004-12-01

    Smaller hippocampal volume in patients with recent-onset posttraumatic stress disorder

    ✓ Peer-reviewed Hippocampus size on brain scans Biological psychiatry

    Key finding: This result replicates previous findings of smaller hippocampal volumes in PTSD patients, but in an underinvestigated population, suggesting that either smaller hippocampal volume is a predisposing factor in the development of PTSD or that damage occurs within months of trauma, rather than a number of years. +4 more findings

  9. 2004-12-01

    Alterations of neuroplasticity in depression: the hippocampus and beyond

    ✓ Peer-reviewed Hippocampus size on brain scans European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

    Key finding: However, recent neuroimaging studies have demonstrated selective structural changes across various limbic and nonlimbic circuits in the brains of depressed patients. +3 more findings

  10. 2004-12-01

    End-of-life content in treatment guidelines for life-limiting diseases

    ✓ Peer-reviewed End-of-life care Journal of palliative medicine

    Key finding: Scores from domains were summed and classified into 3 categories: 4 or less, minimal; 5-12, moderate; and more than 12, significant content. +3 more findings

  11. 2004-12-01

    Strain experienced by caregivers of dementia patients receiving palliative care: findings from the Palliative Excellence in Alzheimer Care Efforts (PEACE) Program

    ✓ Peer-reviewed End-of-life care Journal of palliative medicine

    Key finding: Factor analysis of the Caregiver Strain Index revealed three dimensions of strain (role, personal, and emotional) related to caregiving. +1 more finding

  12. 2004-12-01

    Terminal care for persons with advanced dementia in the nursing home and home care settings

    ✓ Peer-reviewed End-of-life care Journal of palliative medicine

    Key finding: Persons dying with advanced dementia admitted to nursing homes have different characteristics compared to those admitted to home care services. +2 more findings

  13. 2004-12-01

    Neurosyphilis in the modern era

    ✓ Peer-reviewed Clinical safety Journal of neurology, neurosurgery, and psychiatry

    Key finding: The diagnosis of neurosyphilis can be made with reasonable certainty if there is an appropriate neuropsychiatric syndrome associated with a positive CSF VDRL. +2 more findings

  14. 2004-12-01

    Argyrophilic grain disease: a late-onset dementia with distinctive features among tauopathies

    ✓ Peer-reviewed Disease mechanisms Neuropathology : official journal of the Japanese Society of Neuropathology

    Key finding: AgD shows a significant correlation with advancing age, and it became apparent from recent clinicopathological studies that it might account for approximately 5% of all dementia cases. +1 more finding

  15. 2004-12-01

    Neuroimaging correlates of HIV-associated BBB compromise

    ✓ Peer-reviewed Inflammation and the immune system Journal of neuroimmunology

    Key finding: In 25 HIV-infected patients, we found that: (1) the severity of neurocognitive impairment correlated with the degree of BBB breakdown in the basal ganglia; (2) for any given degree of BBB compromise, patients with high plasma viral load were more severely impaired; (3) BBB compromise correlated with mI/Cr in the basal ganglia; and (4) for any given level of mI/Cr, the severity of BBB compromise and the severity of neurocognitive impairment were significantly less in patients on HAART than in those who were HAART-naive. +1 more finding

  16. 2004-12-01

    In vivo detection of microglial activation in frontotemporal dementia

    ✓ Peer-reviewed Inflammation and the immune system Annals of neurology

    Key finding: This implies the presence of an active glial response reflecting progressive neuronal degeneration. +1 more finding

  17. 2004-12-01

    Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse

    ✓ Peer-reviewed Inflammation and the immune system The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: However, their putative nonimmune functions in the brain remain poorly understood. +3 more findings

  18. 2004-12-01

    CSF tau and β-amyloid as biomarkers for mild cognitive impairment

    ✓ Peer-reviewed Tau biomarkers Dialogues in clinical neuroscience

    Key finding: This will be of greater significance if the drugs aimed at slowing down the degenerative process (secondary prevention) prove to affect AD pathology and are clinically effective, such as γ-secretase inhibitors. +3 more findings

  19. 2004-12-01

    Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment

    ✓ Peer-reviewed Risk genes beyond APOE The Journal of clinical investigation

    Key finding: Both synaptic and cognitive deficits are reproduced in mice double transgenic for amyloid precursor protein (AA substitution K670N,M671L) and presenilin-1 (AA substitution M146V). +3 more findings

  20. 2004-12-01

    Neurological complications in renal failure: a review

    ✓ Peer-reviewed Risk factors Clinical neurology and neurosurgery

    Key finding: Dialysis can directly or indirectly be associated with dialysis dementia, dysequilibrium syndrome, aggravation of atherosclerosis, cerebrovascular accidents due to ultrafiltration-related arterial hypotension, hypertensive encephalopathy, Wernicke's encephalopathy, hemorrhagic stroke, subdural hematoma, osmotic myelinolysis, opportunistic infections, intracranial hypertension and mononeuropathy. +1 more finding

  21. 2004-12-01

    Atrophy rate in medial temporal lobe during progression of Alzheimer disease

    ✓ Peer-reviewed Brain scans and imaging Neurology

    Key finding: Increased annual atrophy rate in the medial temporal lobe is a potential diagnostic marker of the progression of Alzheimer disease.

  22. 2004-12-01

    Does the risk of developing dementia increase with the number of episodes in patients with depressive disorder and in patients with bipolar disorder?

    ✓ Peer-reviewed Getting a diagnosis Journal of neurology, neurosurgery, and psychiatry

    Key finding: On average, the risk of dementia seems to increase with the number of episodes in depressive and bipolar affective disorders. +1 more finding

  23. 2004-12-01

    Prevalence and pattern of neuropsychological impairment in human immunodeficiency virus-infected/acquired immunodeficiency syndrome (HIV/AIDS) patients across pre- and post-highly active antiretroviral therapy eras: a combined study of two cohorts

    ✓ Peer-reviewed Getting a diagnosis Journal of neurovirology

    Key finding: The prevalence of impairment was not significantly different across pre-HAART and HAART eras using a standard criterion to define impairment: -2 SD in two neuropsychological measures (41.1%/38.8%). +2 more findings

  24. 2004-12-01

    Rivastigmine for dementia associated with Parkinson's disease

    ✓ Peer-reviewed Treatments The New England journal of medicine

    Key finding: The outcomes were better among patients treated with rivastigmine than among those who received placebo; however, the differences between these two groups were moderate and similar to those reported in trials of rivastigmine for Alzheimer's disease. +2 more findings

  25. 2004-12-01

    Mixed dementia: emerging concepts and therapeutic implications

    ✓ Peer-reviewed Prevention and risk JAMA

    Key finding: The measured benefits in clinical trials for the treatment of mixed dementia are best described as statistically significant differences in cognitive test scores and clinician and caregiver impressions of change.

Browse the library by subject, with the full score breakdown →