Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 23,851–23,875 of 27,380 studies, newest first · page 955 of 1096.
December 2004 25
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2004-12-01
Disruptive behaviors in Veterans Affairs nursing home residents: how different are residents with serious mental illness?
57/100 ✓ Peer-reviewed Digital health tools Journal of the American Geriatrics Society
Key finding: Many VA nursing home residents have SMI.
Full summary, score breakdown and related studies → Original source
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2004-12-01
The epidemiology of the comorbidity of epilepsy in the general population
47/100 ✓ Peer-reviewed Getting a diagnosis Epilepsia
Key finding: The prevalence ratio of many common psychiatric and somatic conditions is increased in adults with epilepsy who consult a primary care physician in the U.K. These findings may have implications in the diagnosis and management of epilepsy and coexisting conditions, as well as in health care provision. +2 more findings
Full summary, score breakdown and related studies → Original source
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2004-12-01
Social resources and cognitive decline in a population of older African Americans and whites
43/100 ✓ Peer-reviewed Prevention trials Neurology
Key finding: Greater social resources, as defined by social networks and social engagement, are associated with reduced cognitive decline in old age. +3 more findings
Full summary, score breakdown and related studies → Original source
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2004-12-01
Induction of hyperphosphorylated tau in primary rat cortical neuron cultures mediated by oxidative stress and glycogen synthase kinase-3
36/100 ✓ Peer-reviewed Drug development Journal of Alzheimer's disease : JAD
Key finding: Here we report that treatment of primary rat cortical neuron cultures with cuprizone, a copper chelator, in combination with oxidative stress (Fe(2+)/H(2)O(2)), significantly increased aberrant tau phosphorylation identified by TG3 immunochemistry. +2 more findings
Full summary, score breakdown and related studies → Original source
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2004-12-01
Benefits of cognitive-motor intervention in MCI and mild to moderate Alzheimer disease
74/100 ✓ Peer-reviewed Treatments Neurology
Key finding: A long-term CMI in ChEI-treated early Alzheimer disease patients produced additional mood and cognitive benefits.
Full summary, score breakdown and related studies → Original source
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2004-12-01
New therapeutic strategies and drug candidates for neurodegenerative diseases: p53 and TNF-alpha inhibitors, and GLP-1 receptor agonists
36/100 ✓ Peer-reviewed Drug development Annals of the New York Academy of Sciences
Key finding: Stimulation of the glucagon-like peptide-1 receptor (GLP-1R) in brain is associated with neurotrophic functions that, additionally, can protect cells against excess glutamate and other toxic insults.
Full summary, score breakdown and related studies → Original source
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2004-12-01
Hippocampal volume in adult burn patients with and without posttraumatic stress disorder
43/100 ✓ Peer-reviewed Hippocampus size on brain scans The American journal of psychiatry
Key finding: PTSD is not a necessary condition for small hippocampal size in trauma-exposed individuals. +4 more findings
Full summary, score breakdown and related studies → Original source
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2004-12-01
Smaller hippocampal volume in patients with recent-onset posttraumatic stress disorder
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Biological psychiatry
Key finding: This result replicates previous findings of smaller hippocampal volumes in PTSD patients, but in an underinvestigated population, suggesting that either smaller hippocampal volume is a predisposing factor in the development of PTSD or that damage occurs within months of trauma, rather than a number of years. +4 more findings
Full summary, score breakdown and related studies → Original source
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2004-12-01
Alterations of neuroplasticity in depression: the hippocampus and beyond
36/100 ✓ Peer-reviewed Hippocampus size on brain scans European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Key finding: However, recent neuroimaging studies have demonstrated selective structural changes across various limbic and nonlimbic circuits in the brains of depressed patients. +3 more findings
Full summary, score breakdown and related studies → Original source
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2004-12-01
End-of-life content in treatment guidelines for life-limiting diseases
43/100 ✓ Peer-reviewed End-of-life care Journal of palliative medicine
Key finding: Scores from domains were summed and classified into 3 categories: 4 or less, minimal; 5-12, moderate; and more than 12, significant content. +3 more findings
Full summary, score breakdown and related studies → Original source
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2004-12-01
Strain experienced by caregivers of dementia patients receiving palliative care: findings from the Palliative Excellence in Alzheimer Care Efforts (PEACE) Program
36/100 ✓ Peer-reviewed End-of-life care Journal of palliative medicine
Key finding: Factor analysis of the Caregiver Strain Index revealed three dimensions of strain (role, personal, and emotional) related to caregiving. +1 more finding
Full summary, score breakdown and related studies → Original source
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2004-12-01
Terminal care for persons with advanced dementia in the nursing home and home care settings
66/100 ✓ Peer-reviewed End-of-life care Journal of palliative medicine
Key finding: Persons dying with advanced dementia admitted to nursing homes have different characteristics compared to those admitted to home care services. +2 more findings
Full summary, score breakdown and related studies → Original source
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2004-12-01
Neurosyphilis in the modern era
45/100 ✓ Peer-reviewed Clinical safety Journal of neurology, neurosurgery, and psychiatry
Key finding: The diagnosis of neurosyphilis can be made with reasonable certainty if there is an appropriate neuropsychiatric syndrome associated with a positive CSF VDRL. +2 more findings
Full summary, score breakdown and related studies → Original source
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2004-12-01
Argyrophilic grain disease: a late-onset dementia with distinctive features among tauopathies
36/100 ✓ Peer-reviewed Disease mechanisms Neuropathology : official journal of the Japanese Society of Neuropathology
Key finding: AgD shows a significant correlation with advancing age, and it became apparent from recent clinicopathological studies that it might account for approximately 5% of all dementia cases. +1 more finding
Full summary, score breakdown and related studies → Original source
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2004-12-01
Neuroimaging correlates of HIV-associated BBB compromise
41/100 ✓ Peer-reviewed Inflammation and the immune system Journal of neuroimmunology
Key finding: In 25 HIV-infected patients, we found that: (1) the severity of neurocognitive impairment correlated with the degree of BBB breakdown in the basal ganglia; (2) for any given degree of BBB compromise, patients with high plasma viral load were more severely impaired; (3) BBB compromise correlated with mI/Cr in the basal ganglia; and (4) for any given level of mI/Cr, the severity of BBB compromise and the severity of neurocognitive impairment were significantly less in patients on HAART than in those who were HAART-naive. +1 more finding
Full summary, score breakdown and related studies → Original source
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2004-12-01
In vivo detection of microglial activation in frontotemporal dementia
48/100 ✓ Peer-reviewed Inflammation and the immune system Annals of neurology
Key finding: This implies the presence of an active glial response reflecting progressive neuronal degeneration. +1 more finding
Full summary, score breakdown and related studies → Original source
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2004-12-01
Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse
47/100 ✓ Peer-reviewed Inflammation and the immune system The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: However, their putative nonimmune functions in the brain remain poorly understood. +3 more findings
Full summary, score breakdown and related studies → Original source
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2004-12-01
CSF tau and β-amyloid as biomarkers for mild cognitive impairment
39/100 ✓ Peer-reviewed Tau biomarkers Dialogues in clinical neuroscience
Key finding: This will be of greater significance if the drugs aimed at slowing down the degenerative process (secondary prevention) prove to affect AD pathology and are clinically effective, such as γ-secretase inhibitors. +3 more findings
Full summary, score breakdown and related studies → Original source
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2004-12-01
Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment
48/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of clinical investigation
Key finding: Both synaptic and cognitive deficits are reproduced in mice double transgenic for amyloid precursor protein (AA substitution K670N,M671L) and presenilin-1 (AA substitution M146V). +3 more findings
Full summary, score breakdown and related studies → Original source
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2004-12-01
Neurological complications in renal failure: a review
43/100 ✓ Peer-reviewed Risk factors Clinical neurology and neurosurgery
Key finding: Dialysis can directly or indirectly be associated with dialysis dementia, dysequilibrium syndrome, aggravation of atherosclerosis, cerebrovascular accidents due to ultrafiltration-related arterial hypotension, hypertensive encephalopathy, Wernicke's encephalopathy, hemorrhagic stroke, subdural hematoma, osmotic myelinolysis, opportunistic infections, intracranial hypertension and mononeuropathy. +1 more finding
Full summary, score breakdown and related studies → Original source
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2004-12-01
Atrophy rate in medial temporal lobe during progression of Alzheimer disease
51/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: Increased annual atrophy rate in the medial temporal lobe is a potential diagnostic marker of the progression of Alzheimer disease.
Full summary, score breakdown and related studies → Original source
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2004-12-01
Does the risk of developing dementia increase with the number of episodes in patients with depressive disorder and in patients with bipolar disorder?
52/100 ✓ Peer-reviewed Getting a diagnosis Journal of neurology, neurosurgery, and psychiatry
Key finding: On average, the risk of dementia seems to increase with the number of episodes in depressive and bipolar affective disorders. +1 more finding
Full summary, score breakdown and related studies → Original source
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2004-12-01
Prevalence and pattern of neuropsychological impairment in human immunodeficiency virus-infected/acquired immunodeficiency syndrome (HIV/AIDS) patients across pre- and post-highly active antiretroviral therapy eras: a combined study of two cohorts
49/100 ✓ Peer-reviewed Getting a diagnosis Journal of neurovirology
Key finding: The prevalence of impairment was not significantly different across pre-HAART and HAART eras using a standard criterion to define impairment: -2 SD in two neuropsychological measures (41.1%/38.8%). +2 more findings
Full summary, score breakdown and related studies → Original source
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2004-12-01
Rivastigmine for dementia associated with Parkinson's disease
78/100 ✓ Peer-reviewed Treatments The New England journal of medicine
Key finding: The outcomes were better among patients treated with rivastigmine than among those who received placebo; however, the differences between these two groups were moderate and similar to those reported in trials of rivastigmine for Alzheimer's disease. +2 more findings
Full summary, score breakdown and related studies → Original source
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2004-12-01
Mixed dementia: emerging concepts and therapeutic implications
66/100 ✓ Peer-reviewed Prevention and risk JAMA
Key finding: The measured benefits in clinical trials for the treatment of mixed dementia are best described as statistically significant differences in cognitive test scores and clinician and caregiver impressions of change.
Full summary, score breakdown and related studies → Original source
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