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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 25,101–25,125 of 27,380 studies, newest first · page 1005 of 1096.

September 2001 5

  1. 2001-09-01

    To tell or not to tell-comparison of older patients' reaction to their diagnosis of dementia and depression

    ✓ Peer-reviewed Disparities International journal of geriatric psychiatry

    Key finding: There was no significant difference between patients with dementia or depression in their wish to know their diagnosis. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2001-09-01

    Incidence of Alzheimer's disease in a rural community in India: the Indo-US study

    ✓ Peer-reviewed Disparities Neurology

    Key finding: These are the first AD incidence rates to be reported from the Indian subcontinent, and they appear to be among the lowest ever reported. +2 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2001-09-01

    Mirtazapine for treatment of depression and comorbidities in Alzheimer disease

    ✓ Peer-reviewed Treatments The Annals of pharmacotherapy

    Key finding: Despite the persistence of memory loss, the patients experienced a prompt and sustained response to mirtazapine. +1 more finding

    Full summary, score breakdown and related studies → Original source

  4. 2001-09-01

    The evolution of A beta peptide burden in the APP23 transgenic mice: implications for A beta deposition in Alzheimer disease

    ✓ Peer-reviewed Genetics Molecular medicine (Cambridge, Mass.)

    Key finding: We suggest that the APP23 Tg mouse may develop an earlier blockage in A beta clearance than the Tg2576 mice, resulting in a more severe accumulation of A beta in the perivascular drainage pathways and in the brain. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2001-09-01

    Neuronal and glial coexpression of argininosuccinate synthetase and inducible nitric oxide synthase in Alzheimer disease

    ✓ Peer-reviewed Biomarkers Journal of neuropathology and experimental neurology

    Key finding: GFAP-positive astrocytes expressing ASS were not increased in AD brains versus controls, whereas the number of iNOS expressing GFAP-positive astrocytes was significantly higher in AD brains. +2 more findings

    Full summary, score breakdown and related studies → Original source

August 2001 18

  1. 2001-08-28

    Prediction of cognitive decline in normal elderly subjects with 2-[(18)F]fluoro-2-deoxy-D-glucose/poitron-emission tomography (FDG/PET)

    ✓ Peer-reviewed Genetics Proceedings of the National Academy of Sciences of the United States of America

    Key finding: In a 3-year longitudinal study of 48 healthy normal elderly, 12 individuals (mean age 72) demonstrated cognitive decline (11 to MCI and 1 to Alzheimer's disease). +1 more finding

    Full summary, score breakdown and related studies → Original source

  2. 2001-08-24

    Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils

    ✓ Peer-reviewed Disease mechanisms Science

    beta-Amyloid plaques and neurofibrillary tangles (NFTs) are the defining neuropathological hallmarks of Alzheimer's disease, but their pathophysiological relation is unclear.

    Full summary, score breakdown and related studies → Original source

  3. 2001-08-24

    Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP

    ✓ Peer-reviewed Disease mechanisms Science

    JNPL3 transgenic mice expressing a mutant tau protein, which develop neurofibrillary tangles and progressive motor disturbance, were crossed with Tg2576 transgenic mice expressing mutant beta-amyloid precursor protein (APP), thus modulating the APP-Abeta (beta-amyloid peptide) environment.

    Full summary, score breakdown and related studies → Original source

  4. 2001-08-21

    Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: implications for the pathogenesis and treatment of Alzheimer's disease

    ✓ Peer-reviewed Down syndrome and Alzheimer's Proceedings of the National Academy of Sciences of the United States of America

    Key finding: We found that transgenic expression of human APP in B6SJL mice, under the prion promoter, results in immune hyporesponsiveness to human Abeta, in terms of both antibody and cellular immune responses. +1 more finding

    Full summary, score breakdown and related studies → Original source

  5. 2001-08 month only

    Homocysteine, vascular dementia and Alzheimer's disease

    ✓ Peer-reviewed Clinical trials Clinical chemistry and laboratory medicine

    Key finding: There are only a few intervention studies, and the results are disappointing for such a frequent disease.

    Full summary, score breakdown and related studies → Original source

  6. 2001-08-01

    Chronic overexpression of the calcineurin inhibitory gene DSCR1 (Adapt78) is associated with Alzheimer's disease

    ✓ Peer-reviewed Down syndrome and Alzheimer's The Journal of biological chemistry

    Key finding: To address this question we first studied DSCR1 (Adapt78) in multiple human tissues and found significant expression in brain, spinal cord, kidney, liver, mammary gland, skeletal muscle, and heart. +2 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2001-08-01

    Cerebral microvascular pathology in aging and Alzheimer's disease

    ✓ Peer-reviewed Vascular contributions Progress in neurobiology

    Key finding: The aging of the central nervous system and the development of incapacitating neurological diseases like Alzheimer's disease (AD) are generally associated with a wide range of histological and pathophysiological changes eventually leading to a compromised cognitive status.

    Full summary, score breakdown and related studies → Original source

  8. 2001-08-01

    Nicastrin binds to membrane-tethered Notch

    ✓ Peer-reviewed Drug development Nature cell biology

    Key finding: In addition, we report that the Notch and betaAPP pathways do not significantly compete with each other.

    Full summary, score breakdown and related studies → Original source

  9. 2001-08-01

    A 1-year, randomized, placebo-controlled study of donepezil in patients with mild to moderate AD

    ✓ Peer-reviewed Genetics Neurology

    Key finding: As the first 1-year, multinational, double-blinded, placebo-controlled study of a cholinesterase inhibitor in AD, these data support donepezil as a well tolerated and effective long-term treatment for patients with AD, with benefits over placebo on global assessment, cognition, and ADL. +2 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2001-08-01

    The Hypothalamic-Pituitary-Adrenal Axis in Major Depressive Disorder: A Brief Primer for Primary Care Physicians

    ✓ Peer-reviewed Hippocampus size on brain scans Primary care companion to the Journal of clinical psychiatry

    Key finding: The data support that HPA axis activation is common in depressed patients. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2001-08-01

    Longitudinal MRI study of hippocampal volume in trauma survivors with PTSD

    ✓ Peer-reviewed Hippocampus size on brain scans The American journal of psychiatry

    Key finding: Smaller hippocampal volume is not a necessary risk factor for developing PTSD and does not occur within 6 months of expressing the disorder.

    Full summary, score breakdown and related studies → Original source

  12. 2001-08-01

    Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection

    ✓ Peer-reviewed Inflammation and the immune system Journal of neurochemistry

    Key finding: Although QUIN has been shown to be produced in neurotoxic concentrations by macrophages and microglia, the role of astrocytes in QUIN production is controversial. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2001-08-01

    In-vivo measurement of activated microglia in dementia

    ✓ Peer-reviewed Inflammation and the immune system Lancet (London, England)

    Key finding: The transition of microglia from the normal resting state to the activated state is associated with an increased expression of receptors known as peripheral benzodiazepine binding sites, which are abundant on cells of mononuclear phagocyte lineage. +3 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2001-08-01

    Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APP(SW) mice

    ✓ Peer-reviewed Risk genes beyond APOE Journal of neuropathology and experimental neurology

    Key finding: We examined whether cholesterol might be present in senile plaques, a hallmark neuropathological feature of AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2001-08-01

    Functional genomics of the Down syndrome

    ✓ Peer-reviewed Down syndrome and Alzheimer's Croatian medical journal

    Key finding: Down syndrome, as a phenotypic result of trisomy 21, is a complex condition with a set of over 30 phenotypic features, which manifest themselves with varying frequencies among affected individuals. +2 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2001-08-01

    A 24-week, randomized, double-blind study of donepezil in moderate to severe Alzheimer's disease

    ✓ Peer-reviewed Treatments Neurology

    Key finding: Patients' mean age was 73.6 years (range 48 to 92 years). +1 more finding

    Full summary, score breakdown and related studies → Original source

  17. 2001-08-01

    A 1-year, placebo-controlled preservation of function survival study of donepezil in AD patients

    ✓ Peer-reviewed Treatments Neurology

    Key finding: Patients with AD continue to show detectable disease progression over time, but treatment with donepezil for 1 year was associated with a 38% reduction in the risk of functional decline compared with placebo. +3 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2001-08-01

    Oxidative damage is the earliest event in Alzheimer disease

    ✓ Peer-reviewed Genetics Journal of neuropathology and experimental neurology

    Key finding: Recently, we demonstrated a significant increase of an oxidized nucleoside derived from RNA, 8-hydroxyguanosine (8OHG), and an oxidized amino acid, nitrotyrosine in vulnerable neurons of patients with Alzheimer disease (AD). +4 more findings

    Full summary, score breakdown and related studies → Original source

July 2001 2

  1. 2001-07-15

    The glial glutamate transporter, GLT‐1, is oxidatively modified by 4‐hydroxy‐2‐nonenal in the Alzheimer's disease brain: the role of Aβ1–42

    ✓ Peer-reviewed Disease mechanisms Journal of Neurochemistry

    Key finding: Western blots of immunoprecipitated HNE-immunoreactive proteins from the inferior parietal lobule of AD and control brains suggest that HNE is conjugated to GLT-1 to a greater extent in the AD brain. +1 more finding

    Full summary, score breakdown and related studies → Original source

  2. 2001-07-01

    The Association Between Caregiver Burden and Caregiver Health-Related Quality of Life in Alzheimer Disease

    ✓ Peer-reviewed Costs and economics Alzheimer Disease & Associated Disorders

    Key finding: The burden experienced by family caregivers of individuals with Alzheimer disease (AD) affects the caregivers' overall health-related quality of life (HRQOL).

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →