Newest studies

FDG-PET improves accuracy in distinguishing frontotemporal dementia and Alzheimer's disease

63/100 ✓ Peer-reviewed Getting a diagnosis Brain : a journal of neurology

Key finding: It also had the highest specificity (97.6%) and sensitivity (86%), and positive likelihood ratio for FTD (36.5). +4 more findings

• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source

Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment

52/100 ✓ Peer-reviewed Mild cognitive impairment Nucleic acids research

Key finding: We found significant BER deficiencies in brains of AD patients due to limited DNA base damage processing by DNA glycosylases and reduced DNA synthesis capacity by DNA polymerase beta. +2 more findings

• Early Stage
• Brain Biology

Full summary, score breakdown and related studies → Original source

New and evolving concepts in the neurotoxicology of lead

36/100 ✓ Peer-reviewed Disparities Toxicology and applied pharmacology

Key finding: Experimental studies have shown that stress can significantly alter the effects of Pb, effects that could potentially be mediated through alterations in the interactions of glucocorticoids with the mesocorticolimbic dopamine system of the brain. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Nutritional challenges for the elderly

33/100 ✓ Peer-reviewed Risk factors Nutrition & Dietetics

Key finding: Unintentional weight loss is associated with increased morbidity and mortality. +4 more findings

• Lifestyle
• Risk Factors

Full summary, score breakdown and related studies → Original source

Neuropsychiatric symptoms are associated with progression from mild cognitive impairment to Alzheimer's disease

51/100 ✓ Peer-reviewed Mild cognitive impairment Dementia and geriatric cognitive disorders

Key finding: These findings suggest that neuropsychiatric symptoms in MCI are a predictor of progression to AD. +3 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

PIB is a non-specific imaging marker of amyloid-beta (Abeta) peptide-related cerebral amyloidosis

40/100 ✓ Peer-reviewed Brain scans and imaging Brain : a journal of neurology

Key finding: The in vivo imaging probe [11C]-PIB (Pittsburgh Compound B, N-methyl[11C]2-(4'-methylaminophenyl-6-hydroxybenzathiazole) is under evaluation as a key imaging tool in Alzheimer's disease (AD) and to date has been assumed to bind with high affinity and specificity to the amyloid structures associated with classical plaques (CPs), one of the pathological hallmarks of the disease. +2 more findings

• Brain Scans
• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Prediction of 6-month mortality in nursing home residents with advanced dementia: validity of a risk score

56/100 ✓ Peer-reviewed End-of-life care Journal of the American Medical Directors Association

Key finding: The original mortality risk score predicted 6-month mortality with reasonable accuracy in 2 validation cohorts of nursing home residents with advanced dementia. +1 more finding

• Care Services

Full summary, score breakdown and related studies → Original source

Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system--too little activation is bad, too much is even worse

36/100 ✓ Peer-reviewed Treatments Neuropharmacology

Key finding: Additionally, impairment of synaptic plasticity (learning) may result not only from neuronal damage per se but may also be a direct consequence of this continuous, non-contingent NMDA receptor activation.

• Treatments

Full summary, score breakdown and related studies → Original source

The effects of tobacco smoke and nicotine on cognition and the brain

36/100 ✓ Peer-reviewed Vascular contributions Neuropsychology review

Key finding: In most studies, exposure to smoke is associated with increased risk for negative preclinical and cognitive outcomes in younger people as well as in older adults.

• Risk Factors
• Brain Biology

Full summary, score breakdown and related studies → Original source

Is gray matter volume an intermediate phenotype for schizophrenia? A voxel-based morphometry study of patients with schizophrenia and their healthy siblings

45/100 ✓ Peer-reviewed Hippocampus size on brain scans Biological psychiatry

Key finding: Our findings confirm and extend previous voxel-based morphometry analyses in ill subjects with schizophrenia. +3 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses

59/100 ✓ Peer-reviewed Genetics The American Journal of Human Genetics

Key finding: PLINK is an open-source C/C++ WGAS tool set developed to address computational and analytic challenges in whole-genome association studies. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Targeting amyloid-beta in glaucoma treatment

36/100 ✓ Peer-reviewed Brain scans and imaging Proceedings of the National Academy of Sciences of the United States of America

Key finding: The development of the devastating neurodegenerative condition, Alzheimer's disease, is strongly associated with amyloid-beta (Abeta) deposition, neuronal apoptosis, and cell loss. +2 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Imaging of amyloid burden and distribution in cerebral amyloid angiopathy

53/100 ✓ Peer-reviewed Brain scans and imaging Annals of Neurology

We conclude that PiB-positron emission tomography can detect cerebrovascular beta-amyloid and may serve as a method for identifying the extent of CAA in living subjects.

• Brain Scans

Full summary, score breakdown and related studies → Original source

ESCRT-III dysfunction causes autophagosome accumulation and neurodegeneration

48/100 ✓ Peer-reviewed Lewy body dementia Current biology : CB

Key finding: Loss of mSnf7-2 in mature cortical neurons caused retraction of dendrites and neuronal cell loss. mSnf7-2 binds to CHMP2B, another ESCRT-III subunit, in which a rare dominant mutation is associated with frontotemporal dementia linked to chromosome 3 (FTD3). +1 more finding

Full summary, score breakdown and related studies → Original source

Long-term care market competition and nursing home dementia special care units

45/100 ✓ Peer-reviewed Health systems and care delivery Medical care

Key finding: Competition from another NH-based SCU was associated with the presence of an SCU in a NH [adjusted odds ratio, 3.3; 95% confidence interval (CI), 1.6-6.6] but there were no associations with other measures. +2 more findings

• Care Services

Full summary, score breakdown and related studies → Original source

Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease

53/100 ✓ Peer-reviewed Drug development Neurology

Key finding: These findings demonstrate an association between antecedent statin use and neurofibrillary tangle burden at autopsy. +3 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Stem cells: a revolution in therapeutics-recent advances in stem cell biology and their therapeutic applications in regenerative medicine and cancer therapies

36/100 ✓ Peer-reviewed Brain scans and imaging Clinical pharmacology and therapeutics

Key finding: We describe how these results have improved our understanding on critical and unique functions of these rare sub-populations of multipotent and undifferentiated cells with an unlimited self-renewal capacity and high plasticity.

• Treatments

Full summary, score breakdown and related studies → Original source

What causes the hippocampal volume decrease in depression? Are neurogenesis, glial changes and apoptosis implicated?

36/100 ✓ Peer-reviewed Hippocampus size on brain scans European archives of psychiatry and clinical neuroscience

Key finding: Even though in vivo imaging studies document significant reductions of hippocampal volume in depressed patients, the exact underlying cellular mechanisms are unclear. +2 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Characteristics associated with delirium in older patients in a medical intensive care unit

64/100 ✓ Peer-reviewed Clinical safety Archives of internal medicine

Key finding: Delirium is frequent among older ICU patients.

Full summary, score breakdown and related studies → Original source

Changes in everyday function in individuals with psychometrically defined mild cognitive impairment in the Advanced Cognitive Training for Independent and Vital Elderly Study

62/100 ✓ Peer-reviewed Prevention trials Journal of the American Geriatrics Society

Key finding: MCI classification guidelines should allow for functional changes in MCI, and clinicians should monitor for such changes. +1 more finding

• Early Stage
• Lifestyle

Full summary, score breakdown and related studies → Original source

Hospitalization of Nursing Home Residents With Cognitive Impairments: The Influence of Organizational Features and State Policies

40/100 ✓ Peer-reviewed Risk factors The Gerontologist

Key finding: Of 359,474 cognitively impaired residents, 49% had a diagnosis of dementia. +4 more findings

• Care Services
• Policy

Full summary, score breakdown and related studies → Original source

Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease

48/100 ✓ Peer-reviewed Risk genes beyond APOE PLoS medicine

Key finding: Understanding the mechanisms of amyloid-beta protein (Abeta) production and clearance in the brain has been essential to elucidating the etiology of Alzheimer disease (AD). +3 more findings

• Brain Biology
• Treatments
• Genetics

Full summary, score breakdown and related studies → Original source

Redox proteomics identification of oxidatively modified brain proteins in Alzheimer's disease and mild cognitive impairment: insights into the progression of this dementing disorder

42/100 ✓ Peer-reviewed Mild cognitive impairment Journal of Alzheimer's disease : JAD

Key finding: In the present review, we summarize our finding of oxidatively modified proteins using a redox proteomics approach in AD and MCI brain to investigate the mechanism that may be involved in MCI and AD pathogenesis and discuss our findings in terms of AD progression and pathogenesis.

• Early Stage
• Brain Biology

Full summary, score breakdown and related studies → Original source

Mild cognitive impairment: a systematic review

56/100 ✓ Peer-reviewed Mild cognitive impairment Journal of Alzheimer's disease : JAD

Key finding: MCI in fact represents a condition with multiple sources of heterogeneity, including clinical presentation, etiology, and prognosis. +4 more findings

• Early Stage
• Other Dementias

Full summary, score breakdown and related studies → Original source

Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements

48/100 ✓ Peer-reviewed Lewy body dementia The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: Interestingly, age-dependent autoantibodies that recognized recombinant tau protein but not the immunogen were detected in the P301L mice. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source