Newest studies

Prestroke cognitive performance, incident stroke, and risk of dementia: the Rotterdam Study

57/100 ✓ Peer-reviewed Long-term cohort studies Stroke

Key finding: Several studies indicate that stroke increases the risk of dementia. +3 more findings

• Risk Factors

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Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer's disease

36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of neurochemistry

Key finding: Most individuals with Down Syndrome (DS) show an early-onset of Alzheimer's disease (AD), which potentially results from the presence of an extra copy of a segment of chromosome 21. +1 more finding

• Down Syndrome
• Brain Biology

Full summary, score breakdown and related studies → Original source

Selective changes of resting-state networks in individuals at risk for Alzheimer's disease

43/100 ✓ Peer-reviewed Brain scans and imaging Proceedings of the National Academy of Sciences of the United States of America

Key finding: Only selected areas of the DMN and the executive attention network demonstrated reduced network-related activity in the patient group. +2 more findings

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STAT1 signaling modulates HIV-1-induced inflammatory responses and leukocyte transmigration across the blood-brain barrier

36/100 ✓ Peer-reviewed Inflammation and the immune system Blood

Key finding: Our previous works demonstrated that HIV-1 activates pro-inflammatory and interferon-alpha-inducible genes in human brain microvascular endothelial cells (HBMECs) and that these genes are linked to the Janus kinase (JAK)/STAT pathway.

• Brain Biology

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Synaptic proteins, neuropathology and cognitive status in the oldest-old

36/100 ✓ Peer-reviewed Cognitive tests and assessment Neurobiology of aging

Key finding: However, senile plaque and neurofibrillary tangle pathology do not consistently differentiate individuals with and without dementia. +3 more findings

• Brain Biology

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NSAID use and dementia risk in the Cardiovascular Health Study: role of APOE and NSAID type

68/100 ✓ Peer-reviewed Genetics Neurology

Key finding: Use of NSAIDs was associated with a lower risk of dementia (adjusted hazard ratio or aHR 0.76, 95% CI or CI 0.60-0.96) and, in particular, AD (aHR 0.63, CI 0.45-0.88), but not VaD (aHR 0.92, CI 0.65-1.28). +2 more findings

• Genetics
• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease

62/100 ✓ Peer-reviewed Genetics Archives of neurology

Key finding: Unadjusted, SNP RS4420638 within APOC1 was strongly associated with AD due entirely to linkage disequilibrium with APOE. +1 more finding

• Genetics

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Neuropsychiatric syndromes in dementia. Results from the European Alzheimer Disease Consortium: part I

54/100 ✓ Peer-reviewed Clinical safety Dementia and geriatric cognitive disorders

Key finding: This large study has provided additional robust evidence for the existence of neuropsychiatric subsyndromes in AD.

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A 93-year-old man with advanced dementia and eating problems

47/100 ✓ Peer-reviewed End-of-life care JAMA

Key finding: More than 5 million Americans have dementia, a leading cause of death among persons older than 65 years in the United States. +3 more findings

• End-of-Life Care

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Peptide Conformation and Supramolecular Organization in Amylin Fibrils: Constraints from Solid-State NMR

40/100 ✓ Peer-reviewed Risk factors Biochemistry

Key finding: The molecular structure of amylin protofilaments in striated ribbons closely resembles the protofilament in amyloid fibrils with a similar morphology formed by the 40-residue beta-amyloid peptide that is associated with Alzheimer's disease.

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Associations of gait speed and other measures of physical function with cognition in a healthy cohort of elderly persons

43/100 ✓ Peer-reviewed Digital health tools The journals of gerontology. Series A, Biological sciences and medical sciences

Key finding: In very healthy older adults, performance-based measures better predict early cognitive decline than do subjective measures, and tasks requiring greater functional reserve, such as fast-paced walking, appear to be the most sensitive in assessing these relationships. +2 more findings

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Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments

36/100 ✓ Peer-reviewed Drug development The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: Here, we found that activation of GSK-3 by wortmannin or transient overexpression of wild-type GSK-3beta could suppress the induction of long-term potentiation (LTP) in rat hippocampus, whereas simultaneous inhibition of GSK-3 by lithium or SB216763 or transient expression of a dominant-negative GSK-3beta mutant (dnGSK-3beta) preserved the LTP. +3 more findings

• Brain Biology

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Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease

36/100 ✓ Peer-reviewed Drug development The Journal of clinical investigation

Key finding: Recent epidemiological evidence suggests that some antihypertensive medications may reduce the risk for Alzheimer disease (AD). +4 more findings

• Brain Biology
• Treatments

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Insight into the kinetic of amyloid beta (1-42) peptide self-aggregation: elucidation of inhibitors' mechanism of action

36/100 ✓ Peer-reviewed Treatments Chembiochem : a European journal of chemical biology

Key finding: When the exponential rate is affected exclusively, such as in the case of Congo red and tetracycline, then the inhibitor affinity might be higher for the pleated beta-sheet structure. +4 more findings

• Treatments
• Brain Biology

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Oxidative damage in mild cognitive impairment and early Alzheimer's disease

45/100 ✓ Peer-reviewed Mild cognitive impairment Journal of neuroscience research

Key finding: Multiple studies show significantly increased levels of lipid peroxidation and protein, DNA, and RNA oxidation in vulnerable regions of the brain of patients with late-stage AD (LAD). +1 more finding

• Early Stage

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Spatial patterns of brain atrophy in MCI patients, identified via high-dimensional pattern classification, predict subsequent cognitive decline

52/100 ✓ Peer-reviewed Mild cognitive impairment NeuroImage

Key finding: In addition to the hippocampus and the medial temporal lobe gray matter, a number of other regions displayed significant atrophy, including orbitofrontal and medial-prefrontal grey matter, cingulate (mainly posterior), insula, uncus, and temporal lobe white matter. +2 more findings

• Early Stage
• Brain Scans

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Cognitive impairment in amyotrophic lateral sclerosis

50/100 ✓ Peer-reviewed Lewy body dementia The Lancet. Neurology

Key finding: We review studies of cognitive impairment in ALS and common neuropsychological test results.

• Other Dementias

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Semantic dementia: a unique clinicopathological syndrome

54/100 ✓ Peer-reviewed Lewy body dementia The Lancet. Neurology

Key finding: Semantic dementia (SD), one of the main clinical variants of frontotemporal dementia, presents a unique combination of clinical and imaging abnormalities. +4 more findings

• Brain Scans

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Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease

55/100 ✓ Peer-reviewed Lewy body dementia The Journal of cell biology

Key finding: Mutations in the ESCRT-III subunit CHMP2B were recently associated with frontotemporal dementia and amyotrophic lateral sclerosis (ALS), neurodegenerative diseases characterized by abnormal ubiquitin-positive protein deposits in affected neurons. +2 more findings

• Other Dementias

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Pure akinesia with gait freezing: a third clinical phenotype of progressive supranuclear palsy

52/100 ✓ Peer-reviewed Digital health tools Movement disorders : official journal of the Movement Disorder Society

Key finding: The clinical syndrome of pure akinesia has most often been associated with progressive supranuclear palsy (PSP) and is characterized by difficulty initiating gait and "freezing" during walking, writing and speaking.

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Distinct antemortem profiles in patients with pathologically defined frontotemporal dementia

45/100 ✓ Peer-reviewed Brain scans and imaging Archives of neurology

Key finding: Clinical, neuropsychological, and imaging profiles can contribute to accurate antemortem diagnosis in FTD. +2 more findings

• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source

Phase lag index: assessment of functional connectivity from multi channel EEG and MEG with diminished bias from common sources

54/100 ✓ Peer-reviewed Brain scans and imaging Human brain mapping

Key finding: The PLI performed at least as well as the PC in detecting true changes in synchronization in model and real data but, at the same token and like-wise the IC, it was much less affected by the influence of common sources and active reference electrodes. +1 more finding

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Amnestic syndrome of the medial temporal type identifies prodromal AD: a longitudinal study

59/100 ✓ Peer-reviewed Getting a diagnosis Neurology

Key finding: The amnestic syndrome of the medial temporal type, defined by the Free and Cued Selective Recall Reminding Test, is able to distinguish patients at an early stage of Alzheimer disease from mild cognitive impairment non-converters. +1 more finding

• Early Stage

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Low vitamin B-12 status and risk of cognitive decline in older adults

62/100 ✓ Peer-reviewed Prevention and risk The American journal of clinical nutrition

Key finding: Low vitamin B-12 status was associated with more rapid cognitive decline. +4 more findings

• Lifestyle

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Vascular factors predict rate of progression in Alzheimer disease

67/100 ✓ Peer-reviewed Prevention and risk Neurology

Key finding: Atrial fibrillation, hypertension, and angina were associated with a greater rate of decline and may represent modifiable risk factors for secondary prevention in Alzheimer disease. +2 more findings

• Prevention
• Diagnosis
• Risk Factors

Full summary, score breakdown and related studies → Original source