Newest studies

Depression rating scales in Parkinson's disease: critique and recommendations

36/100 ✓ Peer-reviewed Risk factors Movement disorders : official journal of the Movement Disorder Society

Key finding: For measurement of severity of depressive symptoms, the Ham-D, MADRS, BDI, and SDS scales are recommended. +4 more findings

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Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees

36/100 ✓ Peer-reviewed Brain scans and imaging The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: The amyloid cascade hypothesis suggests that the aggregation and deposition of amyloid-beta protein is an initiating event in Alzheimer's disease (AD). +4 more findings

• Genetics
• Brain Scans

Full summary, score breakdown and related studies → Original source

Forget me not: palliative care for people with dementia

36/100 ✓ Peer-reviewed End-of-life care Postgraduate medical journal

Key finding: Dementia is a progressive life limiting condition with increasing prevalence and complex needs. +2 more findings

• End-of-Life Care

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Systematic review of driving risk and the efficacy of compensatory strategies in persons with dementia

64/100 ✓ Peer-reviewed Clinical safety Journal of the American Geriatrics Society

Key finding: Drivers with dementia are poorer drivers than cognitively normal drivers, but studies have not consistently demonstrated higher crash rates. +2 more findings

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Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology

49/100 ✓ Peer-reviewed Inflammation and the immune system The Journal of clinical investigation

Key finding: IL-1 beta has emerged as a prime candidate underlying this response. +3 more findings

• Brain Biology

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Effects of sociodemographic and health variables on Mini-Mental State Exam scores in older Australians

50/100 ✓ Peer-reviewed Cognitive tests and assessment The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Key finding: The regression models showed that older age, education levels, language spoken at home and in country of birth, socioeconomic status (SES), occupation, sex, and presence of a mood disorder made significant and unique contributions to performance on the MMSE. +3 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Irreversible motor impairment in young addicts--ephedrone, manganism or both?

49/100 ✓ Peer-reviewed Cognitive tests and assessment Acta neurologica Scandinavica

Key finding: Parkinsonian syndrome related to intravenous use of a "designer" psychostimulant, derived from pseudoephedrine using potassium permanganate as the oxidant, has been observed in drug addicts in Estonia. +3 more findings

Full summary, score breakdown and related studies → Original source

Levels of beta-secretase (BACE1) in cerebrospinal fluid as a predictor of risk in mild cognitive impairment

50/100 ✓ Peer-reviewed Risk genes beyond APOE Archives of general psychiatry

Key finding: Elevated beta-secretase (beta-site amyloid precursor protein-cleaving enzyme 1 [BACE1]) activity has been found in the brains of patients with sporadic Alzheimer disease (AD) compared with controls. +3 more findings

• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

The rate of conversion of mild cognitive impairment to dementia: predictive role of depression

57/100 ✓ Peer-reviewed Mild cognitive impairment International journal of geriatric psychiatry

Key finding: We conclude that conversion rate from MCI to DSM-IIIR dementia was 21.9% over a period of 3 years. +3 more findings

• Early Stage

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Neuropsychological measures in normal individuals that predict subsequent cognitive decline

52/100 ✓ Peer-reviewed Mild cognitive impairment Archives of neurology

Key finding: Tests of both episodic memory and executive function are predictors of time to progression from mild impairment to a clinical diagnosis of Alzheimer disease.

• Early Stage

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Effect of rivastigmine on delay to diagnosis of Alzheimer's disease from mild cognitive impairment: the InDDEx study

73/100 ✓ Peer-reviewed Mild cognitive impairment The Lancet. Neurology

Key finding: Of 1018 study patients enrolled, 508 were randomly assigned to rivastigmine and 510 to placebo; 17.3% of patients on rivastigmine and 21.4% on placebo progressed to AD (hazard ratio 0.85 [95% CI 0.64-1.12]; p=0.225). +3 more findings

• Early Stage
• Diagnosis
• Treatments

Full summary, score breakdown and related studies → Original source

Antipsychotic drug use and mortality in older adults with dementia

72/100 ✓ Peer-reviewed How common it is Annals of internal medicine

Key finding: Atypical antipsychotic use is associated with an increased risk for death compared with nonuse among older adults with dementia. +4 more findings

• Treatments
• Side Effects

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A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population

49/100 ✓ Peer-reviewed Risk genes beyond APOE American journal of human genetics

Key finding: We conducted a genome screen of 103 patients with late-onset AD who were ascertained as part of the Genetic Research in Isolated Populations (GRIP) program that is conducted in a recently isolated population from the southwestern area of The Netherlands. +3 more findings

• Genetics

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Evolution of cognitive dysfunction in an incident Parkinson's disease cohort

68/100 ✓ Peer-reviewed Getting a diagnosis Brain : a journal of neurology

Key finding: We have previously performed detailed clinical and neuropsychological assessments in a community-based cohort of patients with newly diagnosed parkinsonism, and through analysis of a subcohort with idiopathic Parkinson's disease (PD), we have demonstrated that cognitive dysfunction occurs even at the time of PD diagnosis and is heterogeneous.

• Other Dementias

Full summary, score breakdown and related studies → Original source

3D maps from multiple MRI illustrate changing atrophy patterns as subjects progress from mild cognitive impairment to Alzheimer's disease

57/100 ✓ Peer-reviewed Mild cognitive impairment Brain : a journal of neurology

Key finding: Voxel-based morphometry (VBM) was used to assess patterns of grey matter atrophy in the aMCI subjects at each time-point compared to the control group. +3 more findings

• Early Stage

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Characterisation and trophic functions of murine embryonic macrophages based upon the use of a Csf1r-EGFP transgene reporter

44/100 ✓ Peer-reviewed TREM2 and immune genetics Developmental biology

Key finding: These cells are critical for normal development in some organs. +3 more findings

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Occupational risk factors in Alzheimer's disease: a review assessing the quality of published epidemiological studies

55/100 ✓ Peer-reviewed Risk factors Occupational and environmental medicine

Key finding: For pesticides, studies of greater quality and prospective design found increased and statistically significant associations.

• Risk Factors

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Hospice care for patients with dementia

50/100 ✓ Peer-reviewed End-of-life care Journal of pain and symptom management

Key finding: Evaluation of care in all FEHC domains did not significantly differ between groups. +2 more findings

• End-of-Life Care

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Diffusion tensor imaging in preclinical and presymptomatic carriers of familial Alzheimer's disease mutations

59/100 ✓ Peer-reviewed Brain tissue and pathology Brain : a journal of neurology

Key finding: There is evidence from animal, pathological and imaging studies that disruption of white matter occurs in the course of Alzheimer's disease and may be an early event. +3 more findings

• Brain Scans
• Genetics

Full summary, score breakdown and related studies → Original source

Dual Eligibles Faced Serious Health Problems in Shift to Part D

22/100 ✓ Peer-reviewed Health systems and care delivery Psychiatric News

Key finding: The results were announced earlier this month at a press conference in Washington D.C., and were published in the May American Journal of Psychiatry. +4 more findings

• Treatments
• Policy

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Cognitive and neuroimaging predictors of instrumental activities of daily living

45/100 ✓ Peer-reviewed Caregiving Journal of the International Neuropsychological Society : JINS

Key finding: Participants were 124 elderly persons with cognitive function between normal and moderate dementia both with and without significant small vessel cerebrovascular disease. +3 more findings

• Brain Scans

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Proteomics Analysis of the Alzheimer's Disease Hippocampal Proteome

36/100 ✓ Peer-reviewed Genetics Journal of Alzheimer s Disease

Key finding: Protein levels were found to be significantly decreased for peptidyl prolyl cis/trans-isomerase (Pin 1) (0.6-fold compared to control, p<0.03), dihydropyrimidinase-like protein 2 (DRP-2) (0.74-fold compared to control, p<0.02), phosphoglycerate mutase 1 (PGM1) (0.7-fold compared to control, p<0.01), beta-tubulin (0.34-fold compared to control, p<0.01), and aldolase A (0.87-fold compared to control, p<0.0002), whereas the protein levels were found to be significantly increased for enolase (1.35-fold compared to control, p<0.05), ubiquitin carboxyl terminal hydrolase L-1 (UCH L1) (1.31-fold compared to control, p<0.02), triosephosphate isomerase (TPI) (1.38-fold compared to control, p<0.05), carbonic anhydrase II (CAH-II) (1.24-fold compared to control, p=0.05), heat shock protein 70 (1.14-fold compared to control, p<0.03), fructose bisphosphate aldolase (1.38-fold compared to control, p<0.05), ferritin heavy chain (1.23-fold compared to control, p=0.05), 2',3'-cyclic nucleotide 3' phosphodiestrase (CNPase) (1.12-fold compared to control, p<0.02), peroxiredoxin II (1.39-fold compared to control, p<0.05), and adenylate kinase I (1.19-fold compared to control, p<0.03). +2 more findings

• Brain Biology

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Epitope mapping of mAbs AT8 and Tau5 directed against hyperphosphorylated regions of the human tau protein

36/100 ✓ Peer-reviewed Drug development Biochemical and biophysical research communications

Key finding: NFTs mostly consist of hyperphosphorylated versions of the microtubule attached tau protein (PHF-tau) with more than 30 serine and threonine phosphorylation sites identified so far. +4 more findings

• Brain Biology

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Geniposide, a novel agonist for GLP-1 receptor, prevents PC12 cells from oxidative damage via MAP kinase pathway

36/100 ✓ Peer-reviewed Drug development Neurochemistry international

Key finding: The results demonstrated that geniposide increased the expression of anti-apoptotic proteins, including Bcl-2 and heme oxygenase-1 (HO-1), to antagonize the oxidative damage in PC12 cells induced by hydrogen peroxide.

• Prevention

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Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model

57/100 ✓ Peer-reviewed Disease mechanisms Science

Many potential treatments for Alzheimer's disease target amyloid-beta peptides (Abeta), which are widely presumed to cause the disease.

• Brain Biology

Full summary, score breakdown and related studies → Original source