Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 19,826–19,850 of 27,380 studies, newest first · page 794 of 1096.
November 2011 21
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2011-11-04
A genome-wide scan for common variants affecting the rate of age-related cognitive decline
48/100 ✓ Peer-reviewed Genetics Neurobiology of aging
Key finding: Top results were evaluated in 3 independent replication cohorts, consisting of 2279 additional subjects with repeated cognitive testing. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-11-04
Sundown syndrome in persons with dementia: an update
40/100 ✓ Peer-reviewed Clinical safety Psychiatry investigation
Key finding: It is thought to be associated with impaired circadian rhythmicity, environmental and social factors, and impaired cognition. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-11-04
Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease
36/100 ✓ Peer-reviewed Disease mechanisms The Journal of biological chemistry
Key finding: Recent demonstrations that the secretion, uptake, and interneuronal transfer of tau can be modulated by disease-associated tau modifications suggest that secretion may be an important element in tau-induced neurodegeneration. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-11-04
Mild cognitive impairment and dementia: the importance of modifiable risk factors
56/100 ✓ Peer-reviewed Prevention and risk Deutsches Arzteblatt international
Key finding: Modifiable risk factors for MCI should be sought (at the very latest) in persons who already have MCI, as their optimal treatment may improve these patients' cognitive performance or keep the existing deficits from progressing. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-11-03
Multistrategic memory training with the metamemory concept in healthy older adults
40/100 ✓ Peer-reviewed Prevention trials Psychiatry investigation
Key finding: This study shows that multistrategic memory training with the metamemory concept may improve memory ability and other cognitive functions which are not trained and that these improvements may be achieved by pure cognitive training effects. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-11-03
Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
57/100 ✓ Peer-reviewed Vascular contributions Nature reviews. Neuroscience
This article examines mechanisms of blood-brain barrier dysfunction in neurodegenerative disorders, notably Alzheimer's disease, and highlights therapeutic opportunities relating to these neurovascular deficits.
Full summary, score breakdown and related studies → Original source
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2011-11-03
Progression from mild to pronounced MCI is not associated with cerebrospinal fluid biomarker deviations
34/100 ✓ Peer-reviewed Tau biomarkers Dementia and geriatric cognitive disorders
Key finding: Detection of cerebrospinal fluid (CSF) biomarker deviations improve prediction of progression from mild cognitive impairment (MCI) to dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-11 month only
[Neuropathology]
38/100 ✓ Peer-reviewed Brain tissue and pathology Rinsho shinkeigaku = Clinical neurology
Key finding: However, not excluding demented cases, we found olfactory-amygdala extension pathway of LB pathology, which is independent from Braak's ascending pathway.
Full summary, score breakdown and related studies → Original source
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2011-11-01
Improving end-of-life care for people with dementia
36/100 ✓ Peer-reviewed End-of-life care The British journal of psychiatry : the journal of mental science
Key finding: One in three adults over the age of 60 years will die with dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-11-01
Nurses' recognition of delirium in the hospitalized older adult
40/100 ✓ Peer-reviewed Clinical safety Clinical nurse specialist CNS
Key finding: Additional research is warranted regarding the clinical decision-making processes that nurses use in assessing acute cognitive changes and in identifying strategies to improve delirium recognition. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-11-01
Distinguishing Alzheimer's disease from other major forms of dementia
36/100 ✓ Peer-reviewed Getting a diagnosis Expert review of neurotherapeutics
Key finding: Significant advances have been made since the first set of clinical criteria for AD were put forth in 1984 that are now captured in the new criteria for AD published in 2011.
Full summary, score breakdown and related studies → Original source
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2011-11-01
Aβ-degrading enzymes: potential for treatment of Alzheimer disease
44/100 ✓ Peer-reviewed Brain tissue and pathology Journal of neuropathology and experimental neurology
Key finding: Several Aβ-degrading enzymes, including neprilysin (NEP), insulin-degrading enzyme, and endothelin-converting enzyme reduce Aβ levels and protect against cognitive impairment in mouse models of AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-11-01
Late-life social activity and cognitive decline in old age
54/100 ✓ Peer-reviewed Brain tissue and pathology Journal of the International Neuropsychological Society : JINS
Key finding: Using mixed models adjusted for age, sex, education, race, social network size, depression, chronic conditions, disability, neuroticism, extraversion, cognitive activity, and physical activity, more social activity was associated with less cognitive decline during average follow-up of 5.2 years (SD = 2.7). +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-11-01
Alzheimer disease biomarkers are associated with body mass index
55/100 ✓ Peer-reviewed Tau biomarkers Neurology
Key finding: Both low and high body mass index (BMI) has been associated with cognitive impairment and dementia risk, including Alzheimer disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-11-01
Positron emission tomography and neuropathologic estimates of fibrillar amyloid-β in a patient with Down syndrome and Alzheimer disease
40/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Archives of neurology
Key finding: Florbetapir PET can be used to detect increased cerebral-to-cerebellar fibrillar Aβ burden in a Down syndrome patient with Alzheimer disease, even in the presence of frequent amyloid angiopathy and diffuse plaques in the cerebellum. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-11-01
Depression in dementia: epidemiology, mechanisms, and treatment
47/100 ✓ Peer-reviewed Risk factors Current opinion in psychiatry
Key finding: Many studies have explored whether depression in MCI increased the conversion rate to dementia, but findings are inconsistent. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-11-01
Arterial stiffness, pressure and flow pulsatility and brain structure and function: the Age, Gene/Environment Susceptibility--Reykjavik study
63/100 ✓ Peer-reviewed Risk factors Brain : a journal of neurology
Key finding: Aortic stiffness increases with age and vascular risk factor exposure and is associated with increased risk for structural and functional abnormalities in the brain. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-11-01
Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older women
65/100 ✓ Peer-reviewed How common it is Annals of neurology
Key finding: Older, healthy women with decreased circadian activity rhythm amplitude and robustness, and delayed rhythms have increased odds of developing dementia and MCI. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-11-01
Hearing loss and cognition in the Baltimore Longitudinal Study of Aging
61/100 ✓ Peer-reviewed How common it is Neuropsychology
Key finding: Hearing loss is independently associated with lower scores on tests of memory and executive function. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-11-01
Cognitive impairment and outcomes in older adult survivors of acute myocardial infarction: findings from the translational research investigating underlying disparities in acute myocardial infarction patients' health status registry
49/100 ✓ Peer-reviewed Disparities American heart journal
Key finding: Most older patients surviving AMI have measurable CIND. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-11-01
Long-term health outcomes in a British cohort of breast, colorectal and prostate cancer survivors: a database study
57/100 ✓ Peer-reviewed Prevention and risk British journal of cancer
Key finding: The study confirms the occurrence of increased incidence of chronic illnesses in long-term cancer survivors attributable to underlying lifestyle and/or cancer treatments. +1 more finding
Full summary, score breakdown and related studies → Original source
October 2011 4
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2011-10-28
Dual modification of Alzheimer's disease PHF-tau protein by lysine methylation and ubiquitylation: a mass spectrometry approach
43/100 ✓ Peer-reviewed Drug development Acta neuropathologica
Key finding: To identify the modification signature associated with tau lesion formation at single amino acid resolution, immunopurified paired helical filaments were isolated from AD brain and subjected to nanoflow liquid chromatography-tandem mass spectrometry analysis.
Full summary, score breakdown and related studies → Original source
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2011-10-27
c-Jun N-terminal kinase regulates soluble Aβ oligomers and cognitive impairment in AD mouse model
36/100 ✓ Peer-reviewed Disease mechanisms The Journal of biological chemistry
Key finding: Loss of synapses and synaptic dysfunction are closely associated with cognitive impairment in AD patients. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-10-27
Glutamatergic alterations and mitochondrial impairment in a murine model of Alzheimer disease
41/100 ✓ Peer-reviewed Biomarkers Neurobiology of aging
Key finding: Deficits in glutamate neurotransmission and mitochondrial functions were detected in the frontal cortex (FC) and hippopcampus (HIPP) of aged 3×Tg-Alzheimer's disease (AD) mice, compared with their wild type littermates (non-Tg). +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-10-26
Cultural shift
38/100 ✓ Peer-reviewed Health systems and care delivery Nursing older people
Key finding: IT WAS the 'gradual realisation' that what he had been taught about dementiain his nurse and social work training was simply 'not helpful' that prompted Colm Cunningham's interest in dementia research, he says. +2 more findings
Full summary, score breakdown and related studies → Original source
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