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The Classical Complement Cascade Mediates CNS Synapse Elimination
Beth A. Stevens, Nicola J. Allen, Luis E Vazquez, Gareth R. Howell, Karen S. Christopherson, Navid Nouri, Kristina D. Micheva, Adrienne K. Mehalow, Andrew D. Huberman, Benjamin K. Stafford, Alexander Sher, Alan M Litke, John D. Lambris, Stephen J Smith, Simon W. M. John, Ben A. Barres. Cell, 2007-12-01
Topic: Brain proteins, microglia and lab models
We do not hold a plain-English summary of this study yet. Use the links to the original below for its abstract and findings.
Why it matters
Reports that the classical complement cascade mediates synapse elimination in the central nervous system.
How this study scored 59/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on strength of evidence, so that was left out: it earned 56 of the 95 points we could judge it on, which is 59 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Cell) |
| Journal's citation record | 4 / 4 | Cell: journal h-index 1,220 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | — / 5 | No evidence rating recorded — left out of this score |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2007 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 7 / 7 | Cited 3,304 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 157.3 citations a year over 21 year(s) since 2007 |
| Impact for its field and year | 5 / 6 | Cited 23.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 4 / 4 | Cited 778 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Ben A. Barres: h-index 122 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Stanford University: institution h-index 2,684 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 6 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 18083105) |
| Free to read | 2 / 2 | Free to read |
| Points | 56 / 95 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 56 of the 95 points we could judge it on is 59 out of 100. |
| Total | 59 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 16 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Stevens, B. A., Allen, N. J., Vazquez, L. E., Howell, G. R., Christopherson, K. S., Nouri, N., et al. (2007). The Classical Complement Cascade Mediates CNS Synapse Elimination. Cell. https://doi.org/10.1016/j.cell.2007.10.036
Vancouver
Stevens BA, Allen NJ, Vazquez LE, Howell GR, Christopherson KS, Nouri N, et al. The Classical Complement Cascade Mediates CNS Synapse Elimination. Cell. 2007. doi:10.1016/j.cell.2007.10.036. PMID: 18083105.
BibTeX
@article{stevens2007-18083105,
author = {Stevens, Beth A. and Allen, Nicola J. and Vazquez, Luis E and Howell, Gareth R. and Christopherson, Karen S. and Nouri, Navid and Micheva, Kristina D. and Mehalow, Adrienne K. and Huberman, Andrew D. and Stafford, Benjamin K. and Sher, Alexander and Litke, Alan M and Lambris, John D. and Smith, Stephen J and John, Simon W. M. and Barres, Ben A.},
title = {{The Classical Complement Cascade Mediates CNS Synapse Elimination}},
journal = {Cell},
year = {2007},
doi = {10.1016/j.cell.2007.10.036},
pmid = {18083105},
url = {https://doi.org/10.1016/j.cell.2007.10.036}
}
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