Newest studies

PET imaging of amyloid deposition in patients with mild cognitive impairment

49/100 ✓ Peer-reviewed Brain scans and imaging Neurobiology of Aging

Key finding: The mean cortical PIB retention for the MCI patients was intermediate compared to HC and AD. +2 more findings

• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Small-Area Estimation with Spatial Similarity

15/100 ⚠ Preprint — not yet peer-reviewed Risk factors Not indexed

Key finding: We derive a class of composite estimators of small-area quantities that exploit spatial (distance-related) similarity. +4 more findings

Full summary, score breakdown and related studies → Original source

Effect of moderate exercise training on T-helper cell subpopulations in elderly people

34/100 ✓ Peer-reviewed Prevention and risk Exercise immunology review

Key finding: The number of CD4+ and CD28+CD4+ cells significantly increased after the training in EXC (P < 0.05), while CON did not show significant changes. +3 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

The effect of curcumin (turmeric) on Alzheimer's disease: An overview

43/100 ✓ Peer-reviewed Inflammation and the immune system Annals of Indian Academy of Neurology

Key finding: Curcumin (Turmeric), an ancient Indian herb used in curry powder, has been extensively studied in modern medicine and Indian systems of medicine for the treatment of various medical conditions, including cystic fibrosis, haemorrhoids, gastric ulcer, colon cancer, breast cancer, atherosclerosis, liver diseases and arthritis. +3 more findings

Full summary, score breakdown and related studies → Original source

Neuropathological basis of magnetic resonance images in aging and dementia

57/100 ✓ Peer-reviewed Brain tissue and pathology Annals of neurology

Key finding: Magnetic resonance (MR) imaging is used widely for assessment of patients with cognitive impairment, but the pathological correlates are unclear, especially when multiple pathologies are present. +3 more findings

• Brain Scans
• Brain Biology

Full summary, score breakdown and related studies → Original source

Aspirin in Alzheimer's disease (AD2000): a randomised open-label trial

65/100 ✓ Peer-reviewed Cognitive tests and assessment The Lancet. Neurology

Key finding: Cardiovascular risk factors and a history of vascular disease can increase the risk of Alzheimer's disease (AD). +3 more findings

• Clinical Trials
• Risk Factors

Full summary, score breakdown and related studies → Original source

A comparison of the mini mental state exam to the Montreal cognitive assessment in identifying cognitive deficits in Parkinson's disease

52/100 ✓ Peer-reviewed Cognitive tests and assessment Movement disorders : official journal of the Movement Disorder Society

Key finding: The mini-mental state examination (MMSE) often fails to detect early cognitive decline. +3 more findings

• Diagnosis
• Other Dementias

Full summary, score breakdown and related studies → Original source

Diagnostic value of CSF biomarker profile in frontotemporal lobar degeneration

39/100 ✓ Peer-reviewed Tau biomarkers Alzheimer disease and associated disorders

Key finding: Cerebrospinal fluid (CSF) biomarkers have been increasingly studied in dementia clinical and differential diagnosis. +3 more findings

• Biomarkers
• Other Dementias
• Diagnosis

Full summary, score breakdown and related studies → Original source

Simultaneous manipulation of multiple brain targets by green tea catechins: a potential neuroprotective strategy for Alzheimer and Parkinson diseases

42/100 ✓ Peer-reviewed Risk genes beyond APOE CNS neuroscience & therapeutics

Key finding: Novel promising strategies suggest the use of antiinflammatory drugs, antioxidants, iron-complexing molecules, neurotrophic factor delivery, inhibitors of the amyloid precursor protein (APP)-processing secretases, gamma and beta (that generate the amyloid-beta peptides, Abeta), anti-Abeta aggregation molecules, the interference with lipid cholesterol metabolism and naturally occurring plant flavonoids to potentially reverse the course of the diseases. +3 more findings

• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Do CSF total tau, phosphorylated tau, and beta-amyloid 42 help to predict progression of mild cognitive impairment to Alzheimer's disease? A systematic review and meta-analysis of the literature

61/100 ✓ Peer-reviewed Mild cognitive impairment The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry

Key finding: We conclude that when a clinical diagnosis of MCI is made at baseline assessment, low CSF levels of Abeta42 (SMD: -1.57, CI 95% [-2.30 to -0.84], P < 0.001), along with high T-tau (SMD: 1.52, CI 95% [1.25 to 1.79], P < 0.001), and high P-tau (SMD: 1.75, CI 95% [0.99 to 2.51], P < 0.001), help to predict the conversion to Alzheimer's disease as compared to controls subjects.

• Early Stage
• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Mild cognitive impairment: an overview

47/100 ✓ Peer-reviewed Mild cognitive impairment CNS spectrums

Key finding: An algorithm is presented to assist the clinician in identifying subjects and subclassifying them into the various types of MCI. +4 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1

52/100 ✓ Peer-reviewed Mild cognitive impairment The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: Among the AD-related miRNA expression changes, miR-107 was exceptional because miR-107 levels decreased significantly even in patients with the earliest stages of pathology. +2 more findings

• Early Stage
• Policy

Full summary, score breakdown and related studies → Original source

The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases

49/100 ✓ Peer-reviewed Lewy body dementia The EMBO journal

Key finding: Increasing evidence indicates that soluble oligomers are associated with early pathological alterations, and strikingly, oligomeric assemblies of different disease-associated proteins may share common structural features.

• Other Dementias
• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Coenzyme Q10 and oxidative imbalance in Down syndrome: biochemical and clinical aspects

31/100 ✓ Peer-reviewed Down syndrome and Alzheimer's BioFactors (Oxford, England)

Key finding: Down syndrome (DS) is a chromosomal abnormality (trisomy 21) associated with mental retardation and Alzheimer-like dementia, characteristic change of the individual's phenotype and premature ageing. +3 more findings

• Down Syndrome

Full summary, score breakdown and related studies → Original source

The aging brain

45/100 ✓ Peer-reviewed Risk factors Annual review of pathology

Key finding: This review seeks to integrate what is known about age-related cognitive and neuroanatomical changes with recent advances in understanding basic molecular mechanisms that underlie aging. +4 more findings

Full summary, score breakdown and related studies → Original source

The clinical spectrum of freezing of gait in atypical parkinsonism

39/100 ✓ Peer-reviewed Digital health tools Movement disorders : official journal of the Movement Disorder Society

Key finding: VP is the result of multiple small vessel infarcts (lacunar state or Binswanger's disease), particularly involving the frontal, parietal, and basal ganglia regions. +1 more finding

• Other Dementias

Full summary, score breakdown and related studies → Original source

Aripiprazole in the treatment of depressive and anxiety disorders: a review of current evidence

41/100 ✓ Peer-reviewed Disparities CNS drugs

Key finding: Despite the availability of different classes of drugs for the treatment of depressive and anxiety disorders, there are a number of clinically significant unmet needs, such as a high prevalence of treatment resistance, partial response, subsyndromal symptomatology, recurrence and relapse. +3 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

A European consensus on outcome measures for psychosocial intervention research in dementia care

60/100 ✓ Peer-reviewed Caregiving Aging & mental health

Key finding: In conclusion twenty-two measures across nine domains were recommended in order to improve the comparability of intervention studies in Europe.

• Caregiving

Full summary, score breakdown and related studies → Original source

Evidence for improving palliative care at the end of life: a systematic review

67/100 ✓ Peer-reviewed Caregiving Annals of internal medicine

Key finding: Evidence was weak for improving caregiver burdens in cancer and was absent for heart failure. +4 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Progressive aphasia secondary to Alzheimer disease vs FTLD pathology

52/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: A temporoparietal pattern of atrophy on MRI in patients with progressive fluent aphasia and relatively preserved processing speed is suggestive of underlying Alzheimer disease pathology rather than frontotemporal lobar degeneration with ubiquitin-only immunoreactive changes. +2 more findings

• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source

Magnetic resonance imaging white matter hyperintensities and brain volume in the prediction of mild cognitive impairment and dementia

61/100 ✓ Peer-reviewed Brain scans and imaging Archives of neurology

Key finding: High WMH was a predictor of progression from normal to MCI (adjusted hazard ratio [HR], 3.30; 95% confidence interval [CI], 1.33-8.17; P= .01) but not conversion from MCI to all-cause dementia. +1 more finding

• Brain Scans
• Early Stage
• Risk Factors

Full summary, score breakdown and related studies → Original source

Brain volume decline in aging: evidence for a relation between socioeconomic status, preclinical Alzheimer disease, and reserve

55/100 ✓ Peer-reviewed Brain scans and imaging Archives of neurology

Key finding: Cross-sectional and longitudinal observation. +1 more finding

• Brain Scans
• Early Stage
• Health Equity

Full summary, score breakdown and related studies → Original source

Physical exercise at midlife and risk of dementia three decades later: a population-based study of Swedish twins

61/100 ✓ Peer-reviewed Prevention and risk The journals of gerontology. Series A, Biological sciences and medical sciences

Key finding: Exercise at midlife may reduce the odds of dementia in older adulthood, suggesting that exercise interventions should be explored as a potential strategy for delaying disease onset. +2 more findings

• Lifestyle
• Risk Factors

Full summary, score breakdown and related studies → Original source

Vascular risk factors, cognitive decline, and dementia

56/100 ✓ Peer-reviewed Prevention and risk Vascular health and risk management

Key finding: Aging is associated with a large increase in the prevalence and incidence of degenerative (Alzheimer's disease) and vascular dementia, leading to a devastating loss of autonomy. +3 more findings

• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Pathways linking late-life depression to persistent cognitive impairment and dementia

53/100 ✓ Peer-reviewed Prevention and risk Dialogues in clinical neuroscience

Key finding: While neuroimaging evidence suggests that cerebrovascular disease plays a prominent role, it seems that depression alone may also confer substantial risk for developing Alzheimer's disease. +2 more findings

Full summary, score breakdown and related studies → Original source