Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 24,776–24,800 of 27,380 studies, newest first · page 992 of 1096.
August 2002 12
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2002-08-01
Neuroimaging findings in post-traumatic stress disorder. Systematic review
57/100 ✓ Peer-reviewed Hippocampus size on brain scans The British journal of psychiatry : the journal of mental science
Key finding: Evidence from neuroimaging studies has suggested areas of the brain that may be damaged by psychological trauma.
Full summary, score breakdown and related studies → Original source
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2002-08-01
Brain morphometric abnormalities in geriatric depression: long-term neurobiological effects of illness duration
36/100 ✓ Peer-reviewed Hippocampus size on brain scans The American journal of psychiatry
Key finding: These data provide further evidence of structural brain abnormalities in geriatric depression, particularly in patients with a longer course of illness. +1 more finding
Full summary, score breakdown and related studies → Original source
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2002-08-01
Can multidisciplinary guidelines improve the palliation of symptoms in the terminal phase of dementia?
36/100 ✓ Peer-reviewed End-of-life care International journal of palliative nursing
Key finding: Following the implementation of guidelines, there was a significant decrease in the prescribing of antibiotics in the last 2 weeks of life and patients were much more likely to be prescribed analgesia, including opiates. +1 more finding
Full summary, score breakdown and related studies → Original source
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2002-08-01
Regulating factors for microglial activation
39/100 ✓ Peer-reviewed Inflammation and the immune system Biological & pharmaceutical bulletin
Key finding: Microglia play immunological roles in mechanisms underlying the phagocytosis of invading microorganisms and removal of dead or damaged cells. +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-08-01
Visual association test to detect early dementia of the Alzheimer type
51/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of neurology, neurosurgery, and psychiatry
Key finding: The visual association test (VAT) is a brief learning task based on imagery mnemonics. +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-08-01
Differential diagnosis of Alzheimer disease with cerebrospinal fluid levels of tau protein phosphorylated at threonine 231
59/100 ✓ Peer-reviewed Tau biomarkers Archives of neurology
Key finding: Phosphorylation of tau protein at threonine 231 (using full-length tau, 441 amino acids, for the numbering scheme) (p-tau(231)) occurs specifically in postmortem brain tissue of patients with Alzheimer disease (AD) and can be sensitively detected in cerebrospinal fluid (CSF). +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-08-01
CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects
61/100 ✓ Peer-reviewed Mild cognitive impairment Neurology
Key finding: Our data indicate that an increased p-tau(231) level is a potential risk factor for cognitive decline in patients with MCI.
Full summary, score breakdown and related studies → Original source
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2002-08-01
Early inflammation and dementia: a 25-year follow-up of the Honolulu-Asia Aging Study
58/100 ✓ Peer-reviewed How common it is Annals of neurology
Key finding: Inflammatory responses are associated with cardiovascular disease and may be associated with dementing disease. +1 more finding
Full summary, score breakdown and related studies → Original source
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2002-08-01
Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases
50/100 ✓ Peer-reviewed Caregiving Annals of neurology
Key finding: Intracytoplasmic inclusions composed of alpha-synuclein (alpha-syn) are characteristic of neurodegenerative Lewy body disorders. +2 more findings
Full summary, score breakdown and related studies → Original source
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2002-08-01
Caloric intake and the risk of Alzheimer disease
53/100 ✓ Peer-reviewed Prevention and risk Archives of neurology
Key finding: Higher intake of calories and fats may be associated with higher risk of AD in individuals carrying the apolipoprotein E epsilon4 allele. +4 more findings
Full summary, score breakdown and related studies → Original source
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2002-08-01
Postmenopausal hormone replacement therapy: scientific review
68/100 ✓ Peer-reviewed Prevention and risk JAMA
Key finding: Recent results of the Women's Health Initiative (WHI) and the Heart and Estrogen/progestin Replacement Study (HERS) are included for reported outcomes. +4 more findings
Full summary, score breakdown and related studies → Original source
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2002-08-01
Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease
58/100 ✓ Peer-reviewed Genetics Annals of internal medicine
Key finding: The association between the apoE epsilon4 allele and Alzheimer disease does not seem to be mediated by vascular factors.
Full summary, score breakdown and related studies → Original source
July 2002 13
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2002-07-23
Natural history of mild cognitive impairment in older persons
62/100 ✓ Peer-reviewed Mild cognitive impairment Neurology
Key finding: On average, persons with mild cognitive impairment had significantly lower scores at baseline in all cognitive domains. +4 more findings
Full summary, score breakdown and related studies → Original source
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2002-07-19
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
65/100 ✓ Peer-reviewed Disease mechanisms Science
Key finding: The rest of the disease process, including formation of neurofibrillary tangles containing tau protein, is proposed to result from an imbalance between Abeta production and Abeta clearance.
Full summary, score breakdown and related studies → Original source
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2002-07-15
Aromatherapy as a Safe and Effective Treatment for the Management of Agitation in Severe Dementia
47/100 ✓ Peer-reviewed Clinical trials The Journal of Clinical Psychiatry
Key finding: Seventy-one patients completed the trial. +4 more findings
Full summary, score breakdown and related studies → Original source
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2002-07-01
Health care utilization and costs of Alzheimer's disease: the role of co-morbid conditions, disease stage, and pharmacotherapy
47/100 ✓ Peer-reviewed Digital health tools Family medicine
Key finding: Utilization and costs for patients with AD were higher compared to controls and were substantially higher for patients with both AD and co-morbid diseases commonly targeted for disease management. +4 more findings
Full summary, score breakdown and related studies → Original source
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2002-07-01
Neurodegenerative disease: amyloid pores from pathogenic mutations
41/100 ✓ Peer-reviewed Brain tissue and pathology Nature
Key finding: Alzheimer's and Parkinson's diseases are associated with the formation in the brain of amyloid fibrils from beta-amyloid and alpha-synuclein proteins, respectively. +1 more finding
Full summary, score breakdown and related studies → Original source
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2002-07-01
Biochemical markers related to Alzheimer's dementia in serum and cerebrospinal fluid
36/100 ✓ Peer-reviewed Biomarkers Neurobiology of aging
Key finding: Serum 24S-OH-cholesterol may be an early whereas glial fibrillary acidic protein autoantibody level may be a late marker for neurodegeneration. +4 more findings
Full summary, score breakdown and related studies → Original source
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2002-07-01
Involvement of cyclic GMP and protein kinase G in the regulation of apoptosis and survival in neural cells
36/100 ✓ Peer-reviewed Vascular contributions Neuro-Signals
Key finding: Although NO (at high concentrations) is toxic and thought to participate in neuronal cell death during stroke and neurodegenerative diseases (e.g. amyotrophic lateral sclerosis, Alzheimer's disease, HIV dementia and Parkinson's disease), recent evidence suggests that NO at low physiological concentrations can act as an antiapoptotic/prosurvival factor in certain neural cells (e.g.
Full summary, score breakdown and related studies → Original source
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2002-07-01
CADASIL: a common form of hereditary arteriopathy causing brain infarcts and dementia
36/100 ✓ Peer-reviewed Vascular contributions Brain pathology (Zurich, Switzerland)
Key finding: Mutations result in either a gain or loss of one (or rarely, 3) cysteine residue(s) in one of the 34 epidermal growth factor-like repeats in the extracellular amino-terminal region of Notch3.
Full summary, score breakdown and related studies → Original source
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2002-07-01
The hippocampus and depression
36/100 ✓ Peer-reviewed Hippocampus size on brain scans European psychiatry : the journal of the Association of European Psychiatrists
Key finding: In the past two decades, advances in neuroimaging techniques now allow the examination of subtle changes in both regional structure and function that are associated with the pathophysiology of depression. +1 more finding
Full summary, score breakdown and related studies → Original source
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2002-07-01
Reduced hippocampal volume and total white matter volume in posttraumatic stress disorder
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Biological psychiatry
Key finding: Our results replicate previous findings of reduced hippocampal volume in PTSD but also suggest independent, generalized, white matter atrophy. +2 more findings
Full summary, score breakdown and related studies → Original source
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2002-07-01
Cytokines, chemokines, and cytokine receptors in human microglia
45/100 ✓ Peer-reviewed Inflammation and the immune system Journal of neuroscience research
Key finding: Human microglial cells exhibited cell type-specific antigens for macrophage-microglia lineage cells including CD11b (Mac-1), CD68, B7-2 (CD86), HLA-ABC, HLA-DR and ricinus communis aggulutinin lectin-1 (RCA-1), and actively phagocytosed latex beads. +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-07-01
Neurobiology of ammonia
46/100 ✓ Peer-reviewed Inflammation and the immune system Progress in neurobiology
Key finding: Neuropathologic evaluation in these disorders reveals characteristic alterations of astrocyte morphology ranging from cell swelling (acute hyperammonemia) to Alzheimer Type II astrocytosis (chronic hyperammonemia). +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-07-01
Efficacy and safety of memantine in patients with mild to moderate vascular dementia: a randomized, placebo-controlled trial (MMM 300)
65/100 ✓ Peer-reviewed Treatments Stroke
Key finding: Based on the hypothesis of glutamate-induced neurotoxicity (excitotoxicity) in cerebral ischemia, this study examined the efficacy and tolerability of memantine, an uncompetitive N-methyl-D-aspartate antagonist, in the treatment of mild to moderate vascular dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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