Newest studies

The changing prevalence of comorbidity across the age spectrum

44/100 ✓ Peer-reviewed Risk factors Critical reviews in oncology/hematology

Key finding: The purpose of the research was to demonstrate that comorbid health conditions disproportionately affect elderly cancer patients. +4 more findings

• Risk Factors

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Cerebral amyloid angiopathy and its relationship to Alzheimer's disease

50/100 ✓ Peer-reviewed Genetics Acta neuropathologica

Key finding: One with capillary A beta-deposition is characterized by a strong association with the apolipoprotein E (APOE) epsilon 4 allele and by its frequent occurrence in Alzheimer's disease cases whereas the other one lacking capillary A beta-deposits is not associated with APOE epsilon 4. +1 more finding

• Genetics
• Brain Biology

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Metabolic abnormalities associated with mild cognitive impairment in Parkinson disease

56/100 ✓ Peer-reviewed Mild cognitive impairment Neurology

Key finding: The quantification of these alterations with (18)F-fluorodeoxyglucose PET may allow for the objective assessment of the progression and treatment of this disease manifestation. +1 more finding

• Early Stage
• Other Dementias

Full summary, score breakdown and related studies → Original source

Central obesity and increased risk of dementia more than three decades later

73/100 ✓ Peer-reviewed Risk factors Neurology

Key finding: Central obesity in midlife increases risk of dementia independent of diabetes and cardiovascular comorbidities. +2 more findings

• Risk Factors

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Processes of decision making and end-of-life care for patients with dementia in group homes in Japan

40/100 ✓ Peer-reviewed End-of-life care Archives of gerontology and geriatrics

Key finding: About one-third of patients (36.4%) were able to eat by mouth until death. +4 more findings

• End-of-Life Care

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A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristics

36/100 ✓ Peer-reviewed Disease mechanisms Experimental neurology

Key finding: Our strategy was to use the natural tau promoter for expressing the human-tau (htau) gene with two mutations K257T/P301S (double mutant, DM) associated with severe phenotypes of frontotemporal-dementia in humans. +1 more finding

• Brain Biology

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Biomarkers for early diagnosis of Alzheimer disease: 'ALZheimer ASsociated gene'--a new blood biomarker?

39/100 ✓ Peer-reviewed Biomarkers Journal of cellular and molecular medicine

Key finding: Reverse transcriptase-PCR revealed the expression of the transcript of this protein in the cortex and hippocampal regions as well as in lymphocytes of human AD patients. +1 more finding

• Biomarkers
• Diagnosis
• Genetics

Full summary, score breakdown and related studies → Original source

Memantine for Agitation/Aggression and Psychosis in Moderately Severe to Severe Alzheimer's Disease

47/100 ✓ Peer-reviewed Treatments The Journal of Clinical Psychiatry

Key finding: Sixty percent of the total patient group had baseline symptoms of agitation/aggression, delusions, or hallucinations on the NPI. +4 more findings

• Treatments

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Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease

58/100 ✓ Peer-reviewed Brain scans and imaging Brain

Key finding: We found that in Alzheimer's disease brain tissue sections, the preponderance of 6-CN-PiB binding is in plaques immunoreactive to either Abeta42 or Abeta40, and to vascular Abeta deposits. 6-CN-PiB labelling was most robust in compact/cored plaques in the prefrontal and temporal cortices. +1 more finding

• Brain Scans
• Brain Biology

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Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons

36/100 ✓ Peer-reviewed Genetics Proceedings of the National Academy of Sciences of the United States of America

Key finding: Alzheimer's disease (AD) is associated with regional reductions in fluorodeoxyglucose positron emission tomography (FDG PET) measurements of the cerebral metabolic rate for glucose, which may begin long before the onset of histopathological or clinical features, especially in carriers of a common AD susceptibility gene. +2 more findings

• Genetics
• Brain Biology
• Brain Scans

Full summary, score breakdown and related studies → Original source

Microglial activation in brain lesions with tau deposits: comparison of human tauopathies and tau transgenic mice TgTauP301L

36/100 ✓ Peer-reviewed Drug development Brain research

Key finding: Semiquantitative data of the TG and control mice indicated that the immunopositivity of AT8 was closely associated with the number of Iba1-positive microglia in the cortical area. +1 more finding

• Brain Biology

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Novel PSEN1 and PGRN mutations in early-onset familial frontotemporal dementia

45/100 ✓ Peer-reviewed Risk genes beyond APOE Neurobiology of aging

Key finding: We identified two novel heterozygous mutations in two unrelated patients, Cys139Arg in the PGRN gene and Val412Ile in the PSEN1 gene. +3 more findings

• Genetics

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Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in primary human astrocytes

36/100 ✓ Peer-reviewed Vascular contributions The Journal of biological chemistry

Key finding: Taken together, our data indicate that ceftriaxone is a potent modulator of glutamate transport in PHFA through NF-kappaB-mediated EAAT2 promoter activation. +1 more finding

• Brain Biology

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Differences of peripheral inflammatory markers between mild cognitive impairment and Alzheimer's disease

46/100 ✓ Peer-reviewed Mild cognitive impairment Immunology letters

Key finding: Peripheral markers have been used to assess biochemical alterations associated with AD and mild cognitive impairment (MCI) involved in its pathophysiology. +2 more findings

• Early Stage
• Brain Biology

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Assessing change in cognitive function in dementia: the relative utilities of the Alzheimer's Disease Assessment Scale-Cognitive Subscale and the Cognitive Drug Research system

36/100 ✓ Peer-reviewed Cognitive tests and assessment Neuro-degenerative diseases

Key finding: The CDR system has been widely used in dementia work for 20 years and shows good correlations to the ADAS-cog, while additionally assessing the domains of attention, working memory, information processing and retrieval speed of information held in memory. +4 more findings

• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Unrecognized myocardial infarction in relation to risk of dementia and cerebral small vessel disease

57/100 ✓ Peer-reviewed Long-term cohort studies Stroke

Key finding: Men, but not women, with unrecognized myocardial infarction (MI) have an increased risk of cardiac events and stroke compared with those without MI or with recognized MI. +3 more findings

• Risk Factors
• Other Dementias

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Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis

64/100 ✓ Peer-reviewed How common it is Obesity reviews : an official journal of the International Association for the Study of Obesity

Key finding: There was a significant U-shaped association between BMI and dementia (P = 0.034), with dementia risk increased for obesity and underweight. +1 more finding

• Risk Factors

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Safety and efficacy of galantamine in subjects with mild cognitive impairment

82/100 ✓ Peer-reviewed Treatments Neurology

Key finding: Galantamine failed to significantly influence conversion to dementia. +2 more findings

• Treatments
• Early Stage
• Side Effects

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Diabetes and other vascular risk factors for dementia: which factor matters most? A systematic review

65/100 ✓ Peer-reviewed Risk factors European journal of pharmacology

Key finding: Each of these factors has been associated with an increased risk of dementia, but it is uncertain which factor imposes the greatest risk. +2 more findings

• Risk Factors

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Trends in the prevalence and mortality of cognitive impairment in the United States: is there evidence of a compression of cognitive morbidity?

67/100 ✓ Peer-reviewed Caregiving Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Societal investment in building and maintaining cognitive reserve through formal education in childhood and continued cognitive stimulation during work and leisure in adulthood might help limit the burden of dementia among the growing number of older adults worldwide.

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Executive dysfunction and its association with personality and behaviour changes in the development of Alzheimer's disease in adults with Down syndrome and mild to moderate learning disabilities

43/100 ✓ Peer-reviewed Down syndrome and Alzheimer's The British journal of clinical psychology

Key finding: These findings provide further evidence for a specific impairment in frontal-lobe functioning in the preclinical stages of AD in DS. +4 more findings

• Down Syndrome

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2008 Alzheimer's disease facts and figures

40/100 ✓ Peer-reviewed Costs and economics Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Significant cost implications related to Alzheimer's disease and other dementias include an estimated $148 billion annually in direct (Medicare/Medicaid) and indirect (eg, caregiver lost wages and out-of-pocket expenses, decreased business productivity) costs.

• Policy

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Decline in life satisfaction in old age: longitudinal evidence for links to distance-to-death

60/100 ✓ Peer-reviewed End-of-life care Psychology and aging

Key finding: Relative to age-related decline, mortality-related decline (i.e., distance-to-death) accounted for more variance in interindividual differences in life satisfaction change and revealed steeper average rates of decline, by a factor of 2. +1 more finding

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The prevalence of elder abuse and neglect: a systematic review

67/100 ✓ Peer-reviewed Health systems and care delivery Age and ageing

Key finding: Validity of studies was graded by two authors independently using a standardised checklist. +4 more findings

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Current pharmacologic treatment of dementia: a clinical practice guideline from the American College of Physicians and the American Academy of Family Physicians

40/100 ✓ Peer-reviewed Treatments Annals of internal medicine

Key finding: Food and Drug Administration-approved pharmacologic therapies for dementia for outcomes in the domains of cognition, global function, behavior/mood, and quality of life/activities of daily living. +4 more findings

• Treatments
• Caregiving

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