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56/100

✓ Peer-reviewed alzhub usefulness score 56 out of 100. Prevention and risk

Topic: Risk, prevention and care in population studies

Dementia is one of the most important neurological disorders in the elderly. Aging is associated with a large increase in the prevalence and incidence of degenerative (Alzheimer's disease) and vascular dementia, leading to a devastating loss of autonomy. In view of the increasing longevity of populations worldwide, prevention of dementia has turned into a major public health challenge. In the past decade, several vascular risk factors have been found to be associated with vascular dementia but also Alzheimer's disease. Some longitudinal studies, have found significant associations between hypertension, diabetus mellitus, and metabolic syndrome, assessed at middle age, and dementia. Studies assessing the link between hypercholesterolemia, atrial fibrillation, smoking, and dementia have given more conflicting results. Furthermore, some studies have highlighted the possible protective effect of antihypertensive therapy on cognition and some trials are evaluating the effects of statins and treatments for insulin resistance. Vascular risk factors and their treatments are a promising avenue of research for prevention of dementia, and further long-term, placebo-controlled, randomized studies, need to be performed.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Duron, E., & Hanon, O. (2008). Vascular risk factors, cognitive decline, and dementia. Vascular health and risk management. https://doi.org/10.2147/vhrm.s1839

Vancouver

Duron E, Hanon O. Vascular risk factors, cognitive decline, and dementia. Vascular health and risk management. 2008. doi:10.2147/vhrm.s1839. PMID: 18561512.

BibTeX

@article{duron2008-18561512,
  author  = {Duron, E. and Hanon, O.},
  title   = {{Vascular risk factors, cognitive decline, and dementia}},
  journal = {Vascular health and risk management},
  year    = {2008},
  doi     = {10.2147/vhrm.s1839},
  pmid    = {18561512},
  url     = {https://doi.org/10.2147/vhrm.s1839}
}

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Key findings

Aging is associated with a large increase in the prevalence and incidence of degenerative (Alzheimer's disease) and vascular dementia, leading to a devastating loss of autonomy.
In the past decade, several vascular risk factors have been found to be associated with vascular dementia but also Alzheimer's disease.
Some longitudinal studies, have found significant associations between hypertension, diabetus mellitus, and metabolic syndrome, assessed at middle age, and dementia.
Studies assessing the link between hypercholesterolemia, atrial fibrillation, smoking, and dementia have given more conflicting results.

Why it matters

This review reports that vascular risk factors such as hypertension, diabetes, and metabolic syndrome assessed at middle age are associated with dementia, and that antihypertensive therapy may have a protective effect on cognition. It calls for further long-term randomized trials to confirm these findings.

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Study details

Study designlongitudinal study
Evidence strengthHigh

How this study scored 56/100

Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Vascular health and risk management)
Journal's citation record	1 / 4	Vascular Health and Risk Management: journal h-index 99 (OpenAlex, 2026-10-29)
Study design	7 / 12	A longitudinal study following the same people over time
Strength of evidence	5 / 5	Rated “high” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2008 — within 20 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	6 / 7	Cited 314 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	15.7 citations a year over 20 year(s) since 2008
Impact for its field and year	4 / 6	Cited 15.1× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	3 / 6	Cited by 10 other studies in this library
Still being cited	2 / 4	Cited 18 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Olivier Hanon: h-index 62 (OpenAlex, whole career)
Institution's track record	0 / 3	Hôpital Broca: institution h-index 148 (OpenAlex)
Multi-centre collaboration	0 / 3	OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete)
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 18561512)
Free to read	2 / 2	Free to read
Total	56 / 100	—

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