Newest studies

Continuous CSF drainage in AD: results of a double-blind, randomized, placebo-controlled study

64/100 ✓ Peer-reviewed Treatments Neurology

Key finding: We found no benefit to low-flow CSF shunting in subjects with mild to severe Alzheimer disease. +3 more findings

• Clinical Trials
• Biomarkers

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Clinical Symptom Responses to Atypical Antipsychotic Medications in Alzheimer’s Disease: Phase 1 Outcomes From the CATIE-AD Effectiveness Trial

48/100 ✓ Peer-reviewed Clinical safety American Journal of Psychiatry

Key finding: In relation to placebo, the last observation in phase 1 showed greater improvement with olanzapine or risperidone on the Neuropsychiatric Inventory total score, risperidone on the Clinical Global Impression of Changes, olanzapine and risperidone on the Brief Psychiatric Rating Scale (BPRS) hostile suspiciousness factor, and risperidone on the BPRS psychosis factor. +4 more findings

• Clinical Trials
• Side Effects
• Treatments

Full summary, score breakdown and related studies → Original source

Physical activity and Alzheimer's disease: from prevention to therapeutic perspectives

43/100 ✓ Peer-reviewed Prevention trials Journal of the American Medical Directors Association

Key finding: In addition to its convincing multiple benefits, an increasing body of evidence suggests that an active life has a protective effect on brain functioning in elders. +2 more findings

• Prevention
• Lifestyle
• Treatments

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Increased binding of peripheral benzodiazepine receptor in Alzheimer's disease measured by positron emission tomography with [11C]DAA1106

44/100 ✓ Peer-reviewed Inflammation and the immune system Biological psychiatry

Key finding: Peripheral benzodiazepine receptor (PBR) in the brain of Alzheimer's disease (AD) patients has been discussed in relation to the role of gliosis in AD. +3 more findings

• Side Effects

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Therapeutic applications of pomegranate (Punica granatum L.): a review

36/100 ✓ Peer-reviewed Risk factors PubMed

Key finding: The pomegranate, Punica granatum L., is an ancient, mystical, unique fruit borne on a small, long-living tree cultivated throughout the Mediterranean region, as far north as the Himalayas, in Southeast Asia, and in California and Arizona in the United States. +4 more findings

• Risk Factors
• Treatments

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Alzheimer's disease, amnestic mild cognitive impairment, and age-associated memory impairment: current understanding and progress toward integrative prevention

43/100 ✓ Peer-reviewed End-of-life care Alternative medicine review : a journal of clinical therapeutic

Key finding: Age-associated memory impairment is a feasible target for early intervention against AD, beginning with the modifiable AD risk factors - smoking, hypertension, homocysteine, type 2 diabetes, insulin resistance, and obesity. +4 more findings

• Early Stage
• Prevention
• Brain Biology

Full summary, score breakdown and related studies → Original source

ApoE promotes the proteolytic degradation of Abeta

36/100 ✓ Peer-reviewed Genetics Neuron

Key finding: Apolipoprotein E is associated with age-related risk for Alzheimer's disease and plays critical roles in Abeta homeostasis. +1 more finding

• Genetics

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Microbleed topography, leukoaraiosis, and cognition in probable Alzheimer disease from the Sunnybrook dementia study

57/100 ✓ Peer-reviewed Vascular contributions Archives of neurology

Key finding: Occipital predominance of microbleeds with corresponding parietooccipital leukoaraiosis has not been well described in prior imaging studies of AD. +2 more findings

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Regional brain abnormalities associated with long-term heavy cannabis use

47/100 ✓ Peer-reviewed Hippocampus size on brain scans Archives of general psychiatry

Key finding: These results provide new evidence of exposure-related structural abnormalities in the hippocampus and amygdala in long-term heavy cannabis users and corroborate similar findings in the animal literature. +4 more findings

• Brain Scans

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Predictors of well-being in bereaved former hospice caregivers: the role of caregiving stressors, appraisals, and social resources

36/100 ✓ Peer-reviewed End-of-life care Palliative & supportive care

Key finding: Our results indicated that patient diagnosis (cancer or dementia) and caregiver appraisals (stressfulness of functional impairment and positive aspects of caregiving) were not predictors on any of our well-being outcomes. +4 more findings

• End-of-Life Care
• Caregiving

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Overcoming educational barriers for advance care planning in Latinos with video images

45/100 ✓ Peer-reviewed End-of-life care Journal of palliative medicine

Key finding: Educational level was an independent predictor of end-of-life preferences after hearing a verbal description of advanced dementia. +4 more findings

• End-of-Life Care

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Planning the Restructuring of Long-Term Care: The Demand, Need and Provision of Institutional Long-Term Care Beds in Newfoundland and Labrador

33/100 ✓ Peer-reviewed Health systems and care delivery Healthcare Management Forum

Key finding: A decision tree suggested that optimal placement was 7% to housing, 34% to supervised care, 17% to supervised care for cognitive impairment and 42% to nursing home care.

• Care Services

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Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology

56/100 ✓ Peer-reviewed Risk genes beyond APOE Nature medicine

Key finding: Transforming growth factor-betas (TGF-betas) are pleiotropic cytokines that have key roles in immune cell activation, inflammation and repair after injury. +3 more findings

• Brain Biology

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The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice

58/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of clinical investigation

Key finding: Recently, autophagy has been implicated in neurodegeneration, but whether it is detrimental or protective remains unclear. +3 more findings

• Brain Biology

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Neuronal hypertrophy in asymptomatic Alzheimer disease

61/100 ✓ Peer-reviewed Mild cognitive impairment Journal of neuropathology and experimental neurology

Key finding: The goal of this study is to understand the morphometric substrate of ASYMAD subjects compared with mild cognitive impairment and definite AD cases. +1 more finding

• Brain Biology

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Concomitant TAR-DNA-binding protein 43 pathology is present in Alzheimer disease and corticobasal degeneration but not in other tauopathies

51/100 ✓ Peer-reviewed Lewy body dementia Journal of neuropathology and experimental neurology

Key finding: It was restricted to the dentate gyrus and entorhinal cortex in approximately 75% of cases; approximately 25% showed more widespread TDP-43 pathology in frontal and temporal cortices, resembling the FTLD-U subtype associated with progranulin mutations. +3 more findings

• Other Dementias
• Brain Biology

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[Biochemical alterations in patients with Down syndrome]

30/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Orvosi hetilap

Key finding: Plasma homocysteine value proved to be lower in 7 of the 30 and higher in 6 of the 30 patients studied than the reference range. +2 more findings

• Down Syndrome

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Reduced telomere length in older men with premutation alleles of the fragile X mental retardation 1 gene

33/100 ✓ Peer-reviewed Down syndrome and Alzheimer's American journal of medical genetics. Part A

Key finding: These observations suggest that similar shortening may occur in people with fragile X-associated tremor/ataxia syndrome (FXTAS), which frequently is accompanied by dementia. +1 more finding

• Genetics
• Down Syndrome

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Alzheimer and frontotemporal pathology in subsets of primary progressive aphasia

52/100 ✓ Peer-reviewed Risk factors Annals of neurology

Key finding: Subtyping PPA helps to predict AD versus frontotemporal lobar degeneration pathology at the group level. +3 more findings

• Other Dementias
• Brain Biology

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Hypertension and cerebrovascular dysfunction

50/100 ✓ Peer-reviewed Risk factors Cell metabolism

Key finding: Essential hypertension has devastating effects on the brain, being the major cause of stroke and a leading cause of dementia. +3 more findings

• Risk Factors

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Elderly patients with dementia-related symptoms of severe agitation and aggression: consensus statement on treatment options, clinical trials methodology, and policy

47/100 ✓ Peer-reviewed Disparities The Journal of clinical psychiatry

Key finding: This article outlines methodological enhancements to better evaluate treatment approaches in future registration trials and provides an algorithm for improving the treatment of these patients in nursing home and non-nursing home settings. +2 more findings

• Treatments
• Clinical Trials
• Side Effects

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Health literacy not race predicts end-of-life care preferences

51/100 ✓ Peer-reviewed Disparities Journal of palliative medicine

Key finding: A video of a patient with advanced dementia may overcome communication barriers associated with low health literacy. +3 more findings

• End-of-Life Care

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Effectiveness of interventions that assist caregivers to support people with dementia living in the community: a systematic review

50/100 ✓ Peer-reviewed Caregiving International journal of evidence-based healthcare

Key finding: A comprehensive search of relevant databases, hand searching and cross referencing found 685 articles that were assessed for relevance to the review. +4 more findings

• Caregiving

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Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial

71/100 ✓ Peer-reviewed Caregiving JAMA

Key finding: Circadian rhythm disturbances have been associated with these symptoms. +1 more finding

• Clinical Trials

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Brief screening for mild cognitive impairment in elderly outpatient clinic: validation of the Korean version of the Montreal Cognitive Assessment

46/100 ✓ Peer-reviewed Getting a diagnosis Journal of geriatric psychiatry and neurology

Key finding: The results obtained show that the MoCA-K is brief, reliable, and suitable for use as a screening tool to screen MCI patients in elderly outpatient clinic settings.

• Diagnosis
• Early Stage

Full summary, score breakdown and related studies → Original source