Newest studies

Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation

36/100 ✓ Peer-reviewed Lewy body dementia Journal of neurochemistry

Key finding: These diseases, known as synucleinopathies, include Parkinson's disease, dementia with Lewy bodies (LBs), diffuse LB disease, the LB variant of Alzheimer's disease, multiple system atrophy, and neurodegeneration with brain iron accumulation type I. +4 more findings

• Other Dementias
• Brain Biology

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Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice

44/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

Key finding: To determine the role that BACE1 plays in the development of Abeta-driven AD-like pathology, we have crossed PDAPP mice, a transgenic mouse model of AD overexpressing human mutated APP, onto mice with either a homozygous or heterozygous BACE1 gene knockout. +3 more findings

• Brain Biology
• Digital Tools

Full summary, score breakdown and related studies → Original source

Graph theoretical analysis of complex networks in the brain

40/100 ✓ Peer-reviewed Brain scans and imaging Nonlinear biomedical physics

Key finding: In particular, significant progress has been made in understanding the relationship between the structural properties of networks and the nature of dynamics taking place on these networks. +3 more findings

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The role of higher-level cognitive function in gait: executive dysfunction contributes to fall risk in Alzheimer's disease

49/100 ✓ Peer-reviewed Prevention and risk Dementia and geriatric cognitive disorders

Key finding: Studies reported over the past 10 years, however, have documented a prevalence of falls in AD patients significantly higher than in age-matched normal elders; also persons with AD have been observed to have different walking patterns with characteristics that increase gait instability.

• Lifestyle

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The Hawthorne Effect: a randomised, controlled trial

73/100 ✓ Peer-reviewed Caregiving BMC medical research methodology

Key finding: We found that more intensive follow-up of individuals in a placebo-controlled clinical trial of Ginkgo biloba for treating mild-moderate dementia resulted in a better outcome than minimal follow-up, as measured by their cognitive functioning. +3 more findings

• Clinical Trials

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Drug development for CNS disorders: strategies for balancing risk and reducing attrition

36/100 ✓ Peer-reviewed Costs and economics Nature reviews. Drug discovery

Key finding: The development of new therapies for CNS disorders such as Alzheimer's disease has the potential to provide patients with significant improvements in quality of life, as well as reduce the future economic burden on health-care systems. +1 more finding

• Treatments

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Prevalence of neuropsychiatric symptoms in a large sample of Dutch nursing home patients with dementia

43/100 ✓ Peer-reviewed Health systems and care delivery International journal of geriatric psychiatry

Key finding: Prevalence rates of neuropsychiatric symptoms in Dutch nursing home patients with dementia residing in SCUs are high, especially agitation and apathy.

• Care Services

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Environmental and dietary risk factors in Alzheimer's disease

36/100 ✓ Peer-reviewed Risk factors Expert review of neurotherapeutics

Key finding: The evidence examined in this review provides a brief overview of the current literature on selected, significant risk factors in promoting amyloid-beta accumulation and aggregation, thus contributing to neurodegeneration.

• Risk Factors
• Lifestyle

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The precuneus and consciousness

36/100 ✓ Peer-reviewed Risk factors CNS spectrums

Key finding: These findings, along with the widespread connectivity pattern, suggest that the precuneus may play a central role in the neural network correlates of consciousness.

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The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice

36/100 ✓ Peer-reviewed Risk factors The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: Together, our data suggest that the APP C terminus is dispensable and that APPs alpha is sufficient to mediate the physiological functions of APP assessed by these tests.

• Brain Biology
• Digital Tools

Full summary, score breakdown and related studies → Original source

Silent brain infarcts: a systematic review

67/100 ✓ Peer-reviewed Vascular contributions The Lancet. Neurology

Key finding: Although silent infarcts, by definition, lack clinically overt stroke-like symptoms, they are associated with subtle deficits in physical and cognitive function that commonly go unnoticed.

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Longitudinal MRI and cognitive change in healthy elderly

47/100 ✓ Peer-reviewed Hippocampus size on brain scans Neuropsychology

Key finding: Hierarchical multiple regression indicated that a decrease in hippocampus was associated with a decline in MEM, whereas decreased cortical gray matter and increased WMSH were independently associated with a decline in EXEC. +2 more findings

• Brain Scans

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Risk factors for delirium at discharge: development and validation of a predictive model

50/100 ✓ Peer-reviewed Clinical safety Archives of internal medicine

Key finding: A predictive model based on 5 risk factors has been successfully validated for prediction of delirium at discharge in hospitalized older patients. +1 more finding

• Risk Factors

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Doing as much as I can do: the meaning of activity for people with dementia

36/100 ✓ Peer-reviewed Clinical safety Aging & mental health

Key finding: While it is assumed that persons with dementia benefit from being involved in meaningful activity, research examining this claim is limited. +1 more finding

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Computer-based cognitive intervention for dementia: preliminary results of a randomized clinical trial

71/100 ✓ Peer-reviewed Prevention trials Giornale italiano di medicina del lavoro ed ergonomia

Key finding: Preliminary results show a significant performance decline only in the control group at the 9-month follow-up compared to both baseline and the 3-month follow-up. +1 more finding

• Clinical Trials

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The National Alzheimer's Coordinating Center (NACC) Database: The Uniform Data Set

48/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer Disease & Associated Disorders

The National Alzheimer's Coordinating Center (NACC) is responsible for developing and maintaining a database of participant information collected from the 29 Alzheimer's Disease Centers (ADCs) funded by the National Institute on Aging (NIA).

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Multiple imputation: review of theory, implementation and software

50/100 ✓ Peer-reviewed Brain tissue and pathology Statistics in medicine

Key finding: In many medical settings missing data can cause difficulties in estimation, precision and inference. +3 more findings

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Galantamine treatment of vascular dementia: a randomized trial

69/100 ✓ Peer-reviewed Treatments Neurology

Key finding: In this multinational, randomized, double-blind, placebo-controlled, parallel-group clinical trial, 788 patients with probable VaD who also satisfied strict centrally read MRI criteria were randomized to receive galantamine or placebo. +3 more findings

• Treatments
• Clinical Trials
• Other Dementias

Full summary, score breakdown and related studies → Original source

Defining mild cognitive impairment in Parkinson's disease

49/100 ✓ Peer-reviewed Cognitive tests and assessment Movement disorders : official journal of the Movement Disorder Society

Key finding: We categorized 86 PD subjects in a brain bank population as either cognitively normal (PD-CogNL), PD-MCI using criteria that included a 1.5 standard deviation or greater deficit upon neuropsychological testing consistently across at least one cognitive domain without dementia, and PD dementia (PD-D) using DSM-IV criteria. +3 more findings

• Early Stage
• Other Dementias

Full summary, score breakdown and related studies → Original source

Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment

44/100 ✓ Peer-reviewed Mild cognitive impairment Archives of neurology

Key finding: Free radical-mediated oxidative damage is thought to play a role in the pathogenesis of Alzheimer disease. +3 more findings

• Early Stage

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TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions

59/100 ✓ Peer-reviewed Lewy body dementia The American journal of pathology

Key finding: Thus, despite significant clinical, genetic, and neuropathological heterogeneity of FTLD-U, TDP-43 is a common pathological substrate underlying a large subset of these disorders, thereby implicating TDP-43 in novel and unifying mechanisms of FTLD pathogenesis.

• Other Dementias
• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Elevated plasma beta-amyloid peptide Abeta(42) levels, incident dementia, and mortality in Down syndrome

59/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Archives of neurology

Key finding: Elevations in plasma Abeta(42) peptide levels are associated with earlier onset of AD and increased risk of death. +3 more findings

• Down Syndrome
• Risk Factors
• Brain Biology

Full summary, score breakdown and related studies → Original source

The epidemiology of the dementias: an update

47/100 ✓ Peer-reviewed Prevention and risk Current opinion in psychiatry

Key finding: Current evidence suggests that vascular factors, such as midlife hypertension, diabetes, and cerebrovascular disease, contribute significantly to the development of dementia and Alzheimer's disease, and that active engagement in mental, physical, and social activities may postpone the onset of dementia by providing cognitive reserve.

• Prevention
• Risk Factors

Full summary, score breakdown and related studies → Original source

Caregiver preference for rivastigmine patches versus capsules for the treatment of Alzheimer disease

66/100 ✓ Peer-reviewed Treatments Neurology

Key finding: Alzheimer disease (AD) has a significant impact on caregivers. +4 more findings

• Treatments
• Clinical Trials
• Caregiving

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Magnetic resonance imaging predictors of cognition in mild cognitive impairment

66/100 ✓ Peer-reviewed Treatments Archives of neurology

Key finding: Medial temporal lobe atrophy seems to be a more important predictor of cognition than small-vessel disease in MCI. +3 more findings

• Brain Scans
• Early Stage
• Clinical Trials

Full summary, score breakdown and related studies → Original source