Newest studies

Instrumental activities of daily living scale for dementia screening in elderly people

44/100 ✓ Peer-reviewed Disparities International psychogeriatrics

Key finding: The IADL-E is a reliable, sensitive and responsive scale of functional abilities useful in dementia screening in a socioculturally heterogeneous population. +1 more finding

• Diagnosis

Full summary, score breakdown and related studies → Original source

Degree of discrepancy between self and other-reported everyday functioning by cognitive status: dementia, mild cognitive impairment, and healthy elders

46/100 ✓ Peer-reviewed Disparities International journal of geriatric psychiatry

Key finding: Although there may be some mild functional changes associated particularly with the MCI-memory impaired subtype, individuals with MCI do not appear to under-report their functional status as can often been seen in persons with dementia. +4 more findings

• Early Stage
• Health Equity

Full summary, score breakdown and related studies → Original source

Clinical characteristics in early Parkinson's disease in a central California population-based study

52/100 ✓ Peer-reviewed Disparities Movement disorders : official journal of the Movement Disorder Society

Key finding: Three fourths of patients received a Hoehn and Yahr Scale score of Stage 2 or higher. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Early environmental origins of neurodegenerative disease in later life

45/100 ✓ Peer-reviewed Disparities Environmental health perspectives

Key finding: In dementia, lead is associated with increased risk in chronically exposed workers.

Full summary, score breakdown and related studies → Original source

Anxiety and depression in family caregivers of people with Alzheimer disease: the LASER-AD study

45/100 ✓ Peer-reviewed Caregiving The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Key finding: Clinicians should be aware of the high rates of anxiety as well as depressive symptoms in family caregivers of people with AD, especially in female caregivers.

• Caregiving

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The oral health assessment tool--validity and reliability

41/100 ✓ Peer-reviewed Caregiving Australian dental journal

Key finding: Four hundred and fifty five residents completed all study phases. +1 more finding

Full summary, score breakdown and related studies → Original source

Visual assessment of atrophy on magnetic resonance imaging in the diagnosis of pathologically confirmed young-onset dementias

43/100 ✓ Peer-reviewed Brain scans and imaging Archives of neurology

Key finding: Despite variation and overlap of atrophy patterns, visual inspection of regional atrophy on MRI may aid in discriminating AD and FTLD.

• Brain Scans
• Diagnosis

Full summary, score breakdown and related studies → Original source

Small vessel disease and general cognitive function in nondisabled elderly: the LADIS study

49/100 ✓ Peer-reviewed Brain scans and imaging Stroke

Key finding: We found WMH and lacunes to be independently associated with general cognitive function in a sample of independently living elderly. +4 more findings

• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source

Change in body mass index and risk of incident Alzheimer disease

55/100 ✓ Peer-reviewed Getting a diagnosis Neurology

Key finding: Declining body mass index (BMI) is associated with increased risk of incident Alzheimer disease (AD). +4 more findings

• Risk Factors

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The International HIV Dementia Scale: a new rapid screening test for HIV dementia

53/100 ✓ Peer-reviewed Getting a diagnosis AIDS (London, England)

Key finding: Full neuropsychological testing should then be performed to confirm a diagnosis of HIV dementia.

• Diagnosis

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Homocysteine and folate as risk factors for dementia and Alzheimer disease

57/100 ✓ Peer-reviewed Getting a diagnosis The American journal of clinical nutrition

Key finding: Over an average follow-up of 4 y, dementia developed in 112 subjects, including 70 who received a diagnosis of AD. +2 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease

36/100 ✓ Peer-reviewed Disease mechanisms Journal of neurochemistry

Key finding: Our data indicate that Abeta(1-42) globulomer is a persistent structural entity formed independently of the fibrillar aggregation pathway. +1 more finding

• Brain Biology

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Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model

51/100 ✓ Peer-reviewed Risk genes beyond APOE Nature neuroscience

Key finding: Thus, inactivation of BACE1 could be important in the treatment of Alzheimer disease. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment

57/100 ✓ Peer-reviewed Hippocampus size on brain scans Neurobiology of aging

Key finding: These two CSF measures consistently improved the diagnostic accuracy over the memory measures and the isoprostane measure incremented the accuracy of the hippocampal volume achieving overall diagnostic accuracies of about 90%. +2 more findings

• Biomarkers
• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Molecular, Structural, and Functional Characterization of Alzheimer's Disease: Evidence for a Relationship between Default Activity, Amyloid, and Memory

57/100 ✓ Peer-reviewed Brain scans and imaging Journal of Neuroscience

Alzheimer's disease (AD) and antecedent factors associated with AD were explored using amyloid imaging and unbiased measures of longitudinal atrophy in combination with reanalysis of previous metabolic and functional studies.

• Brain Scans

Full summary, score breakdown and related studies → Original source

Disease-related modifications in tau affect the interaction between Fyn and Tau

36/100 ✓ Peer-reviewed Disease mechanisms The Journal of biological chemistry

Key finding: We have recently shown that tau interacts with the SH3 domain of Fyn, an Src family non-receptor tyrosine kinase, and is tyrosine-phosphorylated by Fyn on Tyr-18. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Involvement of P2 receptors in the growth and survival of neurons in the CNS

36/100 ✓ Peer-reviewed Brain scans and imaging Pharmacology & therapeutics

Key finding: Recent findings have demonstrated that ATP is a growth factor participating in differentiation, cell proliferation, and survival, as well as a toxic agent that mediates cellular degeneration and death. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

The Rush Memory and Aging Project: study design and baseline characteristics of the study cohort

47/100 ✓ Peer-reviewed Disparities Neuroepidemiology

Key finding: The overall study design involves a detailed assessment of risk factors for AD in older persons without known dementia who agree to annual clinical evaluation and organ donation at the time of death.

• Health Equity

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The Aging, Demographics, and Memory Study: study design and methods

60/100 ✓ Peer-reviewed Getting a diagnosis Neuroepidemiology

Key finding: Linking the ADAMS dementia clinical assessment data to the wealth of available longitudinal HRS data on health, health care utilization, informal care, and economic resources and behavior, will provide a unique opportunity to study the onset of CIND and dementia in a nationally representative population-based sample, as well as the risk factors, prevalence, outcomes, and costs of CIND and dementia. +4 more findings

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Familial Danish dementia: co-existence of Danish and Alzheimer amyloid subunits (ADan AND A{beta}) in the absence of compact plaques

42/100 ✓ Peer-reviewed Down syndrome and Alzheimer's The Journal of biological chemistry

Key finding: Biochemical analysis of extracted amyloid and preamyloid species indicates that as the solubility of the deposits decreases, the heterogeneity and complexity of the extracted peptides exponentially increase. +2 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Cerebrospinal fluid tau and beta-amyloid in Alzheimer patients, disease controls and an age-matched random sample

56/100 ✓ Peer-reviewed Tau biomarkers Neurobiology of aging

Key finding: By comparing patients with AD to HC as reference, tau revealed sensitivity (sens)/specificity (spec) of 88%/80%, p-tau(181) 88%/80%, tau/Abeta42-ratio 81%/85% and phospho-tau(181)/Abeta42-ratio 81%/78%. +3 more findings

• Biomarkers

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Mechanisms of statin-mediated inhibition of small G-protein function

45/100 ✓ Peer-reviewed Inflammation and the immune system The Journal of biological chemistry

Key finding: We have shown previously that statins inhibit a beta-amyloid (Abeta)-mediated inflammatory response through mechanisms independent of cholesterol reduction. +3 more findings

• Brain Biology

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Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration

36/100 ✓ Peer-reviewed Brain scans and imaging Proceedings of the National Academy of Sciences of the United States of America

Key finding: They develop a constellation of changes that mimic the pathology associated with human AMD. +1 more finding

• Genetics

Full summary, score breakdown and related studies → Original source

Functional implications of hippocampal volume and diffusivity in mild cognitive impairment

43/100 ✓ Peer-reviewed Brain scans and imaging NeuroImage

Key finding: Diffusion-Tensor-Imaging (DTI) in MCI patients revealed an association of microstructural changes in hippocampal areas with verbal memory decline. +4 more findings

• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Rivastigmine and donepezil treatment in moderate to moderately-severe Alzheimer's disease over a 2-year period

78/100 ✓ Peer-reviewed Treatments Current medical research and opinion

Key finding: In total, 994 patients received cholinesterase inhibitor treatment (rivastigmine, n = 495; donepezil, n = 499), and 57.9% of patients completed the study. +4 more findings

• Treatments

Full summary, score breakdown and related studies → Original source