Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 19,776–19,800 of 27,380 studies, newest first · page 792 of 1096.
December 2011 23
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2011-12-08
The miR-124 regulates the expression of BACE1/β-secretase correlated with cell death in Alzheimer's disease
43/100 ✓ Peer-reviewed Risk genes beyond APOE Toxicology letters
Key finding: The aim of the present study was to uncover novel potential miR-124 targets and shed light on its function in the cellular AD model. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-12-08
White matter integrity and reaction time intraindividual variability in healthy aging and early-stage Alzheimer disease
42/100 ✓ Peer-reviewed Brain scans and imaging Neuropsychologia
Key finding: Aging and early-stage Alzheimer disease (AD) have been shown to be associated with increased RT intraindividual variability (IIV, as reflected by the coefficient of variation) and an exaggeration of the slow tail of the reaction time (RT) distribution in attentional control tasks, based on ex-Gaussian analyses. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-12-08
MoCA, ACE-R, and MMSE versus the National Institute of Neurological Disorders and Stroke-Canadian Stroke Network Vascular Cognitive Impairment Harmonization Standards Neuropsychological Battery after TIA and stroke
51/100 ✓ Peer-reviewed Getting a diagnosis Stroke
Key finding: Among 91 nondemented subjects completing neuropsychological testing (mean/SD age, 73.4/11.6 years; 44% female; 56% stroke), 39 (42%) had MCI (amnestic multiple domain=10, nonamnestic multiple domain=9, nonamnestic single domain=19, amnestic single domain=1).
Full summary, score breakdown and related studies → Original source
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2011-12-07
A blood-based screening tool for Alzheimer's disease that spans serum and plasma: findings from TARC and ADNI
48/100 ✓ Peer-reviewed Biomarkers PloS one
Key finding: It is possible to create a blood-based screening algorithm that works across both serum and plasma that provides a comparable screening accuracy to that obtained from CSF analyses.
Full summary, score breakdown and related studies → Original source
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2011-12-07
Clopidogrel Use and Early Outcomes Among Older Patients Receiving a Drug-Eluting Coronary Artery Stent
39/100 ✓ Peer-reviewed Health systems and care delivery Circulation Cardiovascular Quality and Outcomes
Key finding: This study was a retrospective analysis of administrative data (20% sample) of 15 996 Medicare Part D enrollees who received a DES in 2006 to 2007. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-12-07
Putting proteins in their place: palmitoylation in Huntington disease and other neuropsychiatric diseases
42/100 ✓ Peer-reviewed Risk genes beyond APOE Progress in neurobiology
Key finding: Palmitoylation is regulated by the opposing enzymes palmitoyl acyltransferases (PATs) and acyl protein thioesterases, which add and remove palmitate from proteins, respectively. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-12-07
A C9orf72 promoter repeat expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum: a gene identification study
61/100 ✓ Peer-reviewed Lewy body dementia The Lancet. Neurology
Key finding: A locus on chromosome 9p21 has been associated with both disorders, and we aimed to identify the causal gene within this region. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-12-06
The neuropathological profile of mild cognitive impairment (MCI): a systematic review
69/100 ✓ Peer-reviewed Mild cognitive impairment Molecular psychiatry
Key finding: A total of 162 studies were identified with varied definition of MCI, settings ranging from population to specialist clinics and a wide range of objectives. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-12-05
Amyloid precursor protein revisited: neuron-specific expression and highly stable nature of soluble derivatives
42/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: APP has been considered a ubiquitously expressed protein. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-12-01
Sleep epidemiology--a rapidly growing field
71/100 ✓ Peer-reviewed Drug development International Journal of Epidemiology
Key finding: First, sleep problems are associated with accidents and human errors. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-12-01
Does feature selection improve classification accuracy? Impact of sample size and feature selection on classification using anatomical magnetic resonance images
36/100 ✓ Peer-reviewed Digital health tools NeuroImage
Key finding: We showed that we could achieve the most accurate characterizations by using prior knowledge of where to expect neurodegeneration (hippocampus and parahippocampal gyrus).
Full summary, score breakdown and related studies → Original source
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2011-12-01
Neurodegeneration across stages of cognitive decline in Parkinson disease
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Archives of neurology
Key finding: Hippocampal atrophy is a biomarker of initial cognitive decline in PD, including impaired memory encoding and storage, suggesting heterogeneity in the neural substrate of memory impairment. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-12-01
A hippocampal marker of recollection memory ability among healthy young adults: contributions of posterior and anterior segments
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Neuron
Key finding: Better memory was associated with larger posterior and smaller anterior segments, as evaluated relative to the uncal apex. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-12-01
Predisposing factors for postoperative delirium after hip fracture repair in individuals with and without dementia
66/100 ✓ Peer-reviewed Clinical safety Journal of the American Geriatrics Society
Key finding: Preoperative determination of dementia status is important for risk stratification for incident delirium after acute hip fracture repair surgery because types and magnitude of predisposing risk factors for postoperative delirium substantially differ based on preoperative dementia status. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-12-01
Cerebral amyloid angiopathy in the elderly
55/100 ✓ Peer-reviewed Brain tissue and pathology Annals of neurology
Key finding: CAA is associated with a high prevalence of magnetic resonance imaging markers of small vessel disease, including cerebral microbleeds and white matter hyperintensities. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-12-01
Comparative lipidomic analysis of mouse and human brain with Alzheimer disease
52/100 ✓ Peer-reviewed Brain tissue and pathology The Journal of biological chemistry
Key finding: Here, a systems-based approach was employed to determine the lipidome of brain tissues affected by AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-12-01
Changes in cognition
45/100 ✓ Peer-reviewed Mild cognitive impairment Neurobiology of aging
Key finding: There are recent reports that amyloid accumulation may also be associated with memory performance in cognitively normal individuals.
Full summary, score breakdown and related studies → Original source
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2011-12-01
Amyloid imaging as a biomarker for cerebral β-amyloidosis and risk prediction for Alzheimer dementia
52/100 ✓ Peer-reviewed Brain scans and imaging Neurobiology of aging
Key finding: This review will consider the issues involved in the use of amyloid imaging in the development and evaluation of drugs for the treatment of Alzheimer's disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-12-01
Montreal cognitive assessment in detecting cognitive impairment in Chinese elderly individuals: a population-based study
48/100 ✓ Peer-reviewed Getting a diagnosis Journal of geriatric psychiatry and neurology
Key finding: The MoCA norms were established considering significant influential factors. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-12-01
Long term incidence of dementia, predictors of mortality and pathological diagnosis in older stroke survivors
66/100 ✓ Peer-reviewed Prevention and risk Brain : a journal of neurology
Key finding: We found that the median survival from the date of the index stroke was 6.72 years (95% confidence intervals: 6.38-7.05). +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-12-01
Sertraline for the treatment of depression in Alzheimer disease: genetic influences
37/100 ✓ Peer-reviewed Treatments Journal of geriatric psychiatry and neurology
Key finding: Treatment outcomes in the DIADS-2 trial were not significantly influenced by genetic variation at the loci that were assessed. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-12-01
Health and nutrition promotion program for patients with dementia (NutriAlz): cluster randomized trial
55/100 ✓ Peer-reviewed Treatments The journal of nutrition, health & aging
Key finding: The NutriAlz program had no effect on functional decline in Alzheimer disease patients living at home over one year, but reduced the risk for malnutrition, as recommendations concerning diet and exercise were provided. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-12-01
A comprehensive genetic association study of Alzheimer disease in African Americans
47/100 ✓ Peer-reviewed Genetics Archives of neurology
Key finding: Some genes contribute to AD pathogenesis in both white and African American cohorts, although it is unclear whether the causal variants are the same. +2 more findings
Full summary, score breakdown and related studies → Original source
November 2011 2
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2011-11-30
Amyloid vs FDG-PET in the differential diagnosis of AD and FTLD
52/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: PiB and FDG showed similar accuracy in discriminating AD and FTLD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-11-30
Disrupted modular brain dynamics reflect cognitive dysfunction in Alzheimer's disease
45/100 ✓ Peer-reviewed Brain scans and imaging NeuroImage
Key finding: The overall modular strength and the number of modules changed significantly in Alzheimer patients. +2 more findings
Full summary, score breakdown and related studies → Original source
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