alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 21,651–21,675 of 27,380 studies, newest first · page 867 of 1096.

February 2009 6

  1. 2009-02-01

    Cerebral microbleeds: a guide to detection and interpretation

    ✓ Peer-reviewed How common it is The Lancet. Neurology

    Key finding: The number of CMBs detected depends on MRI characteristics, such as pulse sequence, sequence parameters, spatial resolution, magnetic field strength, and image post-processing, emphasising the importance of taking into account MRI technique in the interpretation of study results.

    Full summary, score breakdown and related studies → Original source

  2. 2009-02-01

    Educational attainment and cognitive decline in old age

    ✓ Peer-reviewed Disparities Neurology

    Key finding: The results suggest that education is robustly associated with level of cognitive function but not with rate of cognitive decline and that the former association primarily accounts for education's correlation with risk of dementia in old age. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2009-02-01

    Predictors of nursing home admission for persons with dementia

    ✓ Peer-reviewed Getting a diagnosis Medical care

    Key finding: Several results seemed to challenge conventional assumptions of what precipitates NHA among persons with dementia. +2 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2009-02-01

    Health benefits of physical activity in older patients: a review

    ✓ Peer-reviewed Prevention and risk International journal of clinical practice

    Key finding: Moderate but regular physical activity is associated with a reduction in total mortality among older people, a positive effect on primary prevention of coronary heart disease and a significant benefit on the lipid profile. +1 more finding

    Full summary, score breakdown and related studies → Original source

  5. 2009-02-01

    Melatonin fails to improve sleep or agitation in double-blind randomized placebo-controlled trial of institutionalized patients with Alzheimer disease

    ✓ Peer-reviewed Treatments The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

    Key finding: This study failed to find a beneficial effect of exogenous melatonin, consistent with a number of other studies. +1 more finding

    Full summary, score breakdown and related studies → Original source

  6. 2009-02-01

    Mediterranean diet and mild cognitive impairment

    ✓ Peer-reviewed Genetics Archives of neurology

    Key finding: Higher adherence to the MeDi is associated with a trend for reduced risk of developing MCI and with reduced risk of MCI conversion to AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

January 2009 19

  1. 2009-01-31

    Executive decline and dysfunction precedes declines in memory: the Women's Health and Aging Study II

    ✓ Peer-reviewed Cognitive tests and assessment The journals of gerontology. Series A, Biological sciences and medical sciences

    Key finding: Understanding preclinical transitions to impairment in cognitive abilities associated with risks for functional difficulty and dementia. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2009-01-30

    Opposite effects of early maternal deprivation on neurogenesis in male versus female rats

    ✓ Peer-reviewed Hippocampus size on brain scans PloS one

    Key finding: Our data shows that early environment has a critical influence on establishing sex differences in neural plasticity and supports the concept that the setpoint for neurogenesis may be determined during perinatal life. +2 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2009-01-30

    Mechanisms of tau-induced neurodegeneration

    ✓ Peer-reviewed Brain scans and imaging Acta neuropathologica

    Key finding: Some of the abnormally hyperphosphorylated tau ends up both amino and C-terminally truncated. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2009-01-28

    Donepezil treatment of patients with MCI: a 48-week randomized, placebo-controlled trial

    ✓ Peer-reviewed Treatments Neurology

    Key finding: The dual primary efficacy endpoint was not reached. +2 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2009-01-26

    Pathological substrates of cognitive decline in Alzheimer's disease

    ✓ Peer-reviewed Disease mechanisms Frontiers of neurology and neuroscience

    Key finding: The progressive development of Alzheimer's disease (AD)-related lesions such as neurofibrillary tangles,amyloid deposits and synaptic loss within the cerebral cortex is a main event of brain aging.

    Full summary, score breakdown and related studies → Original source

  6. 2009-01-26

    TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria

    ✓ Peer-reviewed TREM2 and immune genetics The Journal of Cell Biology

    Phagocytosis, which is essential for the immune response to pathogens, is initiated by specific interactions between pathogens and cell surface receptors expressed by phagocytes.

    Full summary, score breakdown and related studies → Original source

  7. 2009-01-24

    A blunted cortisol awakening response and hippocampal atrophy in type 2 diabetes mellitus

    ✓ Peer-reviewed Hippocampus size on brain scans Psychoneuroendocrinology

    Key finding: Across all subjects, fasting insulin and hippocampal volume were associated with the CAR, independent of diagnosis. +1 more finding

    Full summary, score breakdown and related studies → Original source

  8. 2009-01-22

    Intrinsic defect of the immune system in children with Down syndrome: a review

    ✓ Peer-reviewed Down syndrome and Alzheimer's Clinical and experimental immunology

    Key finding: Looking back at past and present results of immunological studies in DS children in relation to the clinical consequences they suffer, we conclude that it is more likely that the DS immune system is intrinsically deficient from the very beginning.

    Full summary, score breakdown and related studies → Original source

  9. 2009-01-22

    Regional white matter integrity differentiates between vascular dementia and Alzheimer disease

    ✓ Peer-reviewed Brain scans and imaging Stroke

    Key finding: FA reduction in forceps minor was the most significant area of difference between AD and VaD. +2 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2009-01-21

    Categorical and correlational analyses of baseline fluorodeoxyglucose positron emission tomography images from the Alzheimer's Disease Neuroimaging Initiative (ADNI)

    ✓ Peer-reviewed Cognitive tests and assessment NeuroImage

    Key finding: The AD Neuroimaging Initiative (ADNI) is acquiring FDG PET, volumetric magnetic resonance imaging, and other biomarker measurements in a large longitudinal multi-center study of initially mildly affected probable AD (pAD) patients, amnestic mild cognitive impairment (aMCI) patients, who are at increased AD risk, and cognitively normal controls (NC), and we are responsible for analyzing the PET images using statistical parametric mapping (SPM). +3 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2009-01-21

    The effects of amyloid precursor protein on postsynaptic composition and activity

    ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

    Key finding: We found that APP was present in the postsynaptic density of central excitatory synapses and coimmunoprecipitated with N-methyl-d-aspartate receptors (NMDARs). +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2009-01-21

    Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members

    ✓ Peer-reviewed Lewy body dementia Brain : a journal of neurology

    Key finding: The clinical presentation associated with GRN mutations is heterogeneous and may include clinical probable Alzheimer's disease. +2 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2009-01-21

    Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies

    ✓ Peer-reviewed Lewy body dementia The Journal of biological chemistry

    Key finding: Furthermore, we observed splicing abnormalities in a cell culture system expressing TDP-43 CTFs, and this is significant because the regulation of exon splicing is a known function of TDP-43. +1 more finding

    Full summary, score breakdown and related studies → Original source

  14. 2009-01-20

    Delirium in older emergency department patients: recognition, risk factors, and psychomotor subtypes

    ✓ Peer-reviewed Prevention and risk Academic emergency medicine : official journal of the Society for Academic Emergency Medicine

    Key finding: Inclusion and exclusion criteria were met in 303 patients, and 25 (8.3%) presented to the ED with delirium.

    Full summary, score breakdown and related studies → Original source

  15. 2009-01-19

    Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease

    ✓ Peer-reviewed Biomarkers Neuroscience

    Key finding: Astrocytes associated with the NVU are responsible for maintaining cerebral blood flow and ionic and osmotic balances in the brain. +4 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2009-01-17

    Powerful beneficial effects of macrophage colony-stimulating factor on beta-amyloid deposition and cognitive impairment in Alzheimer's disease

    ✓ Peer-reviewed Caregiving Brain : a journal of neurology

    Key finding: Senile plaques were smaller and less dense in the brain of M-CSF-treated mice compared to littermate controls treated with vehicle solution. +2 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2009-01-16

    Netrin-1 interacts with amyloid precursor protein and regulates amyloid-beta production

    ✓ Peer-reviewed Risk genes beyond APOE Cell death and differentiation

    Key finding: APP is cleaved by proteases generating amyloid-beta (Abeta) peptide, the main component of the amyloid plaques that are associated with Alzheimer's disease. +3 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2009-01-14

    Combined CSF tau, p-tau181 and amyloid-beta 38/40/42 for diagnosing Alzheimer's disease

    ✓ Peer-reviewed Tau biomarkers Journal of neural transmission (Vienna, Austria : 1996)

    Key finding: A significant decrease of CSF Abeta1-42 was the most powerful single marker for differentiation of AD from DCC, yielding accuracies of beyond 85%. +3 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2009-01-14

    FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer's disease

    ✓ Peer-reviewed Getting a diagnosis European journal of nuclear medicine and molecular imaging

    Key finding: Progressive CMRglc reductions on FDG-PET occur years in advance of clinical DAT symptoms in patients with pathologically verified disease.

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →