Newest studies

The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

36/100 ✓ Peer-reviewed Disease mechanisms Proceedings of the National Academy of Sciences of the United States of America

Key finding: Our results from rat mitochondria show that Abeta is transported into mitochondria via the translocase of the outer membrane (TOM) machinery. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Nitrones as therapeutics

36/100 ✓ Peer-reviewed Risk factors Free radical biology & medicine

Key finding: Some derivatives of PBN are significantly more potent than PBN and have undergone extensive commercial development for stroke. +1 more finding

Full summary, score breakdown and related studies → Original source

Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation

40/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of neuroinflammation

Key finding: This study suggests that neuro-inflammatory reaction could contribute to AD pathology, and anti-inflammatory agent could be useful for the prevention of AD. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: a double-blind, active and placebo-controlled study

65/100 ✓ Peer-reviewed Cognitive tests and assessment The Lancet. Neurology

Key finding: The treatment of ischaemic stroke with neuroprotective drugs has been unsuccessful, and whether these compounds can be used to reduce disability after recurrent stroke is unknown. +3 more findings

• Clinical Trials
• Prevention

Full summary, score breakdown and related studies → Original source

Exposure to antipsychotics and risk of stroke: self controlled case series study

43/100 ✓ Peer-reviewed Vascular contributions BMJ (Clinical research ed.)

Key finding: All antipsychotics are associated with an increased risk of stroke, and the risk might be higher in patients receiving atypical antipsychotics than those receiving typical antipsychotics. +3 more findings

• Side Effects
• Risk Factors

Full summary, score breakdown and related studies → Original source

Combining early markers strongly predicts conversion from mild cognitive impairment to Alzheimer's disease

40/100 ✓ Peer-reviewed Hippocampus size on brain scans Biological psychiatry

Key finding: The five-predictor combination strongly predicted conversion to AD and was markedly superior to combining age and MMSE.

• Brain Scans
• Early Stage
• Diagnosis

Full summary, score breakdown and related studies → Original source

Mutated recombinant human glucagon-like peptide-1 protects SH-SY5Y cells from apoptosis induced by amyloid-beta peptide (1-42)

40/100 ✓ Peer-reviewed Drug development Neuroscience letters

Key finding: It has been demonstrated that glucagon-like peptide-1 (GLP-1), which is an endogenous insulinotropic peptide secreted from the gut, binds to its receptor in the brain and possesses neuroprotective effects. +4 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: involvement of oxidative stress and mitogen-activated protein kinase cascades

42/100 ✓ Peer-reviewed Inflammation and the immune system Neuroscience

Key finding: One of the earliest neuropathological changes in AD is the presence of a high number of reactive astrocytes at sites of Abeta deposition. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Proteomic identification of nitrated brain proteins in early Alzheimer's disease inferior parietal lobule

43/100 ✓ Peer-reviewed Mild cognitive impairment Journal of cellular and molecular medicine

Key finding: Eight proteins were found to be significantly nitrated in EAD: peroxiredoxin 2, triose phosphate isomerase, glutamate dehydrogenase, neuropolypeptide h3, phosphoglycerate mutase1, H(+)- transporting ATPase, alpha-enolase and fructose-1,6-bisphosphate aldolase. +1 more finding

• Early Stage
• Brain Biology

Full summary, score breakdown and related studies → Original source

Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia

51/100 ✓ Peer-reviewed Risk factors Human molecular genetics

Key finding: In a series of pathologically confirmed FTLD-U patients without GRN mutations, we show that carriers homozygous for the T-allele of rs5848 have a 3.2-fold increased risk to develop FTLD-U compared with homozygous C-allele carriers (95% CI: 1.50-6.73). +3 more findings

• Risk Factors
• Other Dementias
• Genetics

Full summary, score breakdown and related studies → Original source

Wnt signaling in neuroprotection and stem cell differentiation

36/100 ✓ Peer-reviewed Drug development Progress in neurobiology

Key finding: So far, we have demonstrated that activation of Wnt signaling protects neurons against neurotoxic injuries, including both amyloid-beta (Abeta) fibrils and Abeta oligomers by using either lithium, an inhibitor of the glycogen-synthase-kinase-3beta (GSK-3beta), or different Wnt ligands. +1 more finding

• Treatments

Full summary, score breakdown and related studies → Original source

Hippocampal volume and cortical sources of EEG alpha rhythms in mild cognitive impairment and Alzheimer disease

43/100 ✓ Peer-reviewed Hippocampus size on brain scans NeuroImage

Key finding: Atrophy of hippocampus and alteration of resting eyes-closed electroencephalographic (EEG) rhythms represent important features of mild cognitive impairment (MCI) and Alzheimer's disease (AD). +3 more findings

• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

The ADAM metalloproteinases

40/100 ✓ Peer-reviewed Inflammation and the immune system Molecular aspects of medicine

Key finding: For a growing number of substrates, foremost among them being Notch, cleavage by ADAM sheddases is essential for their subsequent "regulated intramembrane proteolysis" (RIP), which generates cleaved intracellular domains that translocate to the nucleus and regulate gene transcription. +4 more findings

Full summary, score breakdown and related studies → Original source

The brain injury biomarker VLP-1 is increased in the cerebrospinal fluid of Alzheimer disease patients

46/100 ✓ Peer-reviewed Genetics Clinical chemistry

Key finding: These results suggest that neuronal injury markers such as VLP-1 may have utility as biomarkers for AD. +4 more findings

• Biomarkers
• Genetics

Full summary, score breakdown and related studies → Original source

Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer's disease

40/100 ✓ Peer-reviewed Biomarkers PloS one

Key finding: However, male 3xTg-AD mice demonstrated a further reduction in the production of new neurones from 9 months of age (73% decrease) and a complete depletion at 12 months, when compared to controls. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Do in vivo experimental models reflect human cerebral small vessel disease? A systematic review

64/100 ✓ Peer-reviewed Vascular contributions Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Key finding: Fifteen different models were included, under four categories: (1) embolic injuries (injected blood clot, photochemical, detergent-evoked); (2) hypoperfusion/ischaemic injury (bilateral common carotid occlusion/stenosis, striatal endothelin-1 injection, striatal mitotoxin 3-NPA); (3) hypertension-based injuries (surgical narrowing of the aorta, or genetic mutations, usually in the renin-angiotensin system); (4) blood vessel damage (injected proteases, endothelium-targeting viral infection, or genetic mutations affecting vessel walls). +4 more findings

• Other Dementias
• Risk Factors

Full summary, score breakdown and related studies → Original source

Microglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

57/100 ✓ Peer-reviewed Inflammation and the immune system Journal of Neuroscience

Early microglial accumulation in Alzheimer's disease (AD) delays disease progression by promoting clearance of beta-amyloid (Abeta) before formation of senile plaques.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Hippocampus segmentation in MR images using atlas registration, voxel classification, and graph cuts

36/100 ✓ Peer-reviewed Hippocampus size on brain scans NeuroImage

Key finding: This data was previously used in a volumetry study that found significant associations between hippocampal volume and cognitive decline and incidence of dementia. +2 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Pulmonary function, muscle strength and mortality in old age

36/100 ✓ Peer-reviewed Clinical safety Mechanisms of ageing and development

Key finding: In a series of proportional hazards models, we first demonstrated that the association of extremity muscle strength with mortality was no longer significant after including a term for respiratory muscle strength, controlling for age, sex, education, and body mass index. +2 more findings

Full summary, score breakdown and related studies → Original source

Effect of fish oil on cognitive performance in older subjects

55/100 ✓ Peer-reviewed Clinical trials Neurology

Key finding: The mean age of the participants was 70 years, and 55% were male. +4 more findings

• Clinical Trials
• Lifestyle

Full summary, score breakdown and related studies → Original source

Conceptual knowledge is underpinned by the temporal pole bilaterally: convergent evidence from rTMS

36/100 ✓ Peer-reviewed Digital health tools Cerebral cortex (New York, N.Y. : 1991)

Key finding: Studies of semantic dementia patients and some functional neuroimaging studies indicate that the anterior temporal lobes, bilaterally, are the core neural substrate for the formation of semantic representations. +1 more finding

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New insights into brain BDNF function in normal aging and Alzheimer disease

36/100 ✓ Peer-reviewed Disease mechanisms Brain research reviews

Key finding: It is admitted that these cognitive effects result from impaired neuronal plasticity, which is altered in normal aging but mainly in Alzheimer disease. +1 more finding

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An ethnographic study of stigma and ageism in residential care or assisted living

46/100 ✓ Peer-reviewed Health systems and care delivery The Gerontologist

Key finding: Four themes emerged that relate to stigma in RC-AL: (a) ageism in long-term care; (b) stigma as related to disease and illness; (c) sociocultural aspects of stigma; and (d) RC-AL as a stigmatizing setting. +3 more findings

• Care Services

Full summary, score breakdown and related studies → Original source

Effect of regulatory warnings on antipsychotic prescription rates among elderly patients with dementia: a population-based time-series analysis

40/100 ✓ Peer-reviewed Digital health tools CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

Key finding: Although the warnings slowed the growth in the use of atypical antipsychotic drugs among patients with dementia, they did not reduce the overall prescription rate of these potentially dangerous drugs. +4 more findings

• Side Effects

Full summary, score breakdown and related studies → Original source

Resting-state functional connectivity in neuropsychiatric disorders

36/100 ✓ Peer-reviewed Brain scans and imaging Current opinion in neurology

Key finding: This review considers recent advances in the application of resting-state functional magnetic resonance imaging to the study of neuropsychiatric disorders. +1 more finding

• Brain Scans

Full summary, score breakdown and related studies → Original source