Newest studies

Content of advance directives for individuals with advanced dementia

36/100 ✓ Peer-reviewed End-of-life care Journal of aging and health

Key finding: For advance directives to better reflect a person's wishes, discussions with individuals and families about advance directives should include a range of care issues in the settings of terminal illness, persistent vegetative state or end-stage illness.

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

The role of reduced fitness to drive due to medical impairments in explaining crashes involving older drivers

36/100 ✓ Peer-reviewed Clinical safety Traffic injury prevention

Key finding: Medical conditions overall, do impact the fitness to drive of older drivers; however, the crash risk tends to be only slightly to moderately increased. +3 more findings

• Lifestyle

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An open-label trial of Korean red ginseng as an adjuvant treatment for cognitive impairment in patients with Alzheimer's disease

59/100 ✓ Peer-reviewed Cognitive tests and assessment European journal of neurology

Key finding: Ginseng is one of the most popular herbs worldwide. +3 more findings

• Treatments
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Decreased drebrin mRNA expression in Alzheimer disease: correlation with tau pathology

37/100 ✓ Peer-reviewed Tau biomarkers Journal of neuroscience research

Key finding: AD diagnosis was confirmed by decreased drebrin protein and increased Abeta(40) (+464%; P < 0.05), Abeta(42) (+369%; P < 0.0001), Abeta(42/40) ratio (+226%; P < 0.01), total tau (+2,725%; P < 0.0001), and paired helical filament tau (PHFtau; +867%; P < 0.001) compared with controls. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Elevated cerebrospinal fluid BACE1 activity in incipient Alzheimer disease

60/100 ✓ Peer-reviewed Risk genes beyond APOE Archives of neurology

Key finding: We used a sensitive and specific beta-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) assay to determine the relationship between BACE1 activity in cerebrospinal fluid (CSF) and markers of APP metabolism and axonal degeneration in early and late stages of Alzheimer disease (AD). +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Tumorigenesis and neurodegeneration: two sides of the same coin?

36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's BioEssays : news and reviews in molecular, cellular and developmental biology

Key finding: The gene for ataxia-telangiectasia mutated (ATM) is a prototype for this dual mechanism of action, with loss-of-function mutations causing not only selective degeneration of cerebellar neurons but also increased susceptibility to breast cancer and hematologic malignancy. +4 more findings

• Down Syndrome

Full summary, score breakdown and related studies → Original source

Staging dementia using Clinical Dementia Rating Scale Sum of Boxes scores: a Texas Alzheimer's research consortium study

58/100 ✓ Peer-reviewed How common it is Archives of neurology

Key finding: Optimal ranges of CDR-SOB scores corresponding to the global CDR scores were 0.5 to 4.0 for a global score of 0.5, 4.5 to 9.0 for a global score of 1.0, 9.5 to 15.5 for a global score of 2.0, and 16.0 to 18.0 for a global score of 3.0. +1 more finding

Full summary, score breakdown and related studies → Original source

Measuring primary care patients' attitudes about dementia screening

49/100 ✓ Peer-reviewed Disparities International journal of geriatric psychiatry

Key finding: The PRISM-PC questionnaire captures primary care patients' acceptance, perceived harms, and perceived benefits of dementia screening. +1 more finding

• Diagnosis
• Care Services

Full summary, score breakdown and related studies → Original source

The association of race, gender, and comorbidity with mortality and function after hip fracture

53/100 ✓ Peer-reviewed Disparities The journals of gerontology. Series A, Biological sciences and medical sciences

Key finding: The finding of higher mortality and worse mobility for nonwhite patients with hip fractures highlights the need for more research on race/ethnicity disparities in hip fracture care. +2 more findings

• Health Equity

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Effect of infarcts on dementia in the Baltimore longitudinal study of aging

65/100 ✓ Peer-reviewed Caregiving Annals of neurology

Key finding: Cerebrovascular disease is a significant and potentially preventable cause of dementia in the Baltimore Longitudinal Study of Aging. +4 more findings

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Physical frailty in older persons is associated with Alzheimer disease pathology

56/100 ✓ Peer-reviewed Caregiving Neurology

Key finding: Physical frailty in old age is associated with Alzheimer disease pathology in older persons with and without dementia. +4 more findings

• Brain Biology

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Brain morphology in older African Americans, Caribbean Hispanics, and whites from northern Manhattan

57/100 ✓ Peer-reviewed Caregiving Archives of neurology

Key finding: Older age and vascular disease, particularly among African Americans, are associated with increased brain atrophy and WMH burden. +3 more findings

• Health Equity
• Brain Scans

Full summary, score breakdown and related studies → Original source

Caregiver burden among dementia patient caregivers: a review of the literature

45/100 ✓ Peer-reviewed Caregiving Journal of the American Academy of Nurse Practitioners

Key finding: Dementia caregiving has been associated with negative effects on caregiver health and early nursing home placement for dementia patients. +2 more findings

• Caregiving

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Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease

69/100 ✓ Peer-reviewed Treatments Archives of neurology

Key finding: Group differences were seen in skin and subcutaneous tissue concerns (P=.05), including 3 possible drug rashes and 3 reports of hair color change in the treatment groups. +1 more finding

• Clinical Trials
• Treatments
• Side Effects

Full summary, score breakdown and related studies → Original source

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

36/100 ✓ Peer-reviewed Risk genes beyond APOE Trends in neurosciences

Key finding: Perturbed neuronal Ca(2+) homeostasis is implicated in age-related cognitive impairment and Alzheimer's disease (AD). +4 more findings

• Brain Biology

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Efficacy, safety and tolerability of rivastigmine capsules in patients with probable vascular dementia: the VantagE study

63/100 ✓ Peer-reviewed Treatments Current medical research and opinion

Key finding: Consistent with trials evaluating other cholinesterase inhibitors, rivastigmine did not provide consistent efficacy in probable VaD. +2 more findings

• Treatments
• Side Effects
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

75/100 ✓ Peer-reviewed Treatments The Lancet. Neurology

Key finding: Inclusion criteria were early AD (mini-mental state examination [MMSE] score between 20 and 26 points or Alzheimer's disease assessment scale-cognitive subscale (ADAS-cog) score between 10 and 25 points), taking a stable dose of acetylcholinesterase inhibitor (donepezil, galantamine, or rivastigmine) for at least 4 months, a modified Hachinski score of 4 points or less, and CT or MRI results that were consistent with AD. +2 more findings

• Clinical Trials
• Treatments
• Biomarkers

Full summary, score breakdown and related studies → Original source

MRI measures of temporoparietal regions show differential rates of atrophy during prodromal AD

51/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: These results demonstrate that temporoparietal regions show differential rates of atrophy on MRI during prodromal Alzheimer disease (AD). +4 more findings

• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Atrial fibrillation in stroke-free patients is associated with memory impairment and hippocampal atrophy

50/100 ✓ Peer-reviewed Risk factors European heart journal

Key finding: AF contributes to stroke and secondary cognitive decline. +2 more findings

• Brain Scans

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Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors

57/100 ✓ Peer-reviewed Prevention and risk The Lancet. Neurology

Key finding: Current data from developing countries suggest that age-adjusted dementia prevalence estimates in 65 year olds are high (>or=5%) in certain Asian and Latin American countries, but consistently low (1-3%) in India and sub-Saharan Africa; Alzheimer's disease accounts for 60% whereas vascular dementia accounts for approximately 30% of the prevalence.

• Risk Factors
• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

PCSK9 is required for the disposal of non-acetylated intermediates of the nascent membrane protein BACE1

41/100 ✓ Peer-reviewed Risk genes beyond APOE EMBO reports

Key finding: Specifically, BACE1 is transiently acetylated on seven lysine residues in the lumen of the endoplasmic reticulum/endoplasmic reticulum-Golgi intermediate compartment (ER/ERGIC). +3 more findings

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Prevalence of dementia in Latin America, India, and China: a population-based cross-sectional survey

68/100 ✓ Peer-reviewed Getting a diagnosis Lancet (London, England)

Key finding: The prevalence of DSM-IV dementia varied widely, from 0.3% (95% CI 0.1-0.5) in rural India to 6.3% (5.0-7.7) in Cuba. +1 more finding

Full summary, score breakdown and related studies → Original source

Amyloid load in Parkinson's disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography

47/100 ✓ Peer-reviewed Treatments Journal of neurology, neurosurgery, and psychiatry

Key finding: This study suggests that amyloid load is significantly raised in over 80% of subjects with DLB, while amyloid pathology is infrequent in PDD. +4 more findings

• Other Dementias
• Brain Scans

Full summary, score breakdown and related studies → Original source

Two-year progression from mild cognitive impairment to dementia: to what extent do different definitions agree?

62/100 ✓ Peer-reviewed Mild cognitive impairment Journal of the American Geriatrics Society

Key finding: Current classifications of MCI have variable outcomes in population-based samples. +1 more finding

• Early Stage

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Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome

46/100 ✓ Peer-reviewed Down syndrome and Alzheimer's The Journal of biological chemistry

Key finding: The increased dosage of Dyrk1A in DS brain due to trisomy of chromosome 21 correlates to an increase in 3R-tau level, which on abnormal hyperphosphorylation and aggregation of tau results in neurofibrillary degeneration.

• Down Syndrome

Full summary, score breakdown and related studies → Original source