Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 21,876–21,900 of 27,380 studies, newest first · page 876 of 1096.
September 2008 25
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2008-09-11
Adherence to Mediterranean diet and health status: meta-analysis
83/100 ✓ Peer-reviewed Prevention and risk BMJ (Clinical research ed.)
Key finding: Greater adherence to a Mediterranean diet is associated with a significant improvement in health status, as seen by a significant reduction in overall mortality (9%), mortality from cardiovascular diseases (9%), incidence of or mortality from cancer (6%), and incidence of Parkinson's disease and Alzheimer's disease (13%). +2 more findings
Full summary, score breakdown and related studies → Original source
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2008-09-11
Functional decline in cognitive impairment--the relationship between physical and cognitive function
36/100 ✓ Peer-reviewed Prevention trials Neuroepidemiology
Key finding: Poor physical function and muscle strength coexisted with cognitive impairment. +2 more findings
Full summary, score breakdown and related studies → Original source
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2008-09-11
The prevalence of joint contractures, pressure sores, painful shoulder, other pain, falls, and depression in the year after a severely disabling stroke
52/100 ✓ Peer-reviewed Clinical safety Stroke
Key finding: Immobility-related complications are very common in the first year after a severely disabling stroke. +1 more finding
Full summary, score breakdown and related studies → Original source
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2008-09-10
Gene expression profile of the bone microenvironment in human fragility fracture bone
41/100 ✓ Peer-reviewed TREM2 and immune genetics Bone
Key finding: Although some progress has been made in identifying genes that may contribute to OP disease, much of the genetic component of OP has yet to be accounted for. +3 more findings
Full summary, score breakdown and related studies → Original source
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2008-09-09
Default-mode brain dysfunction in mental disorders: a systematic review
57/100 ✓ Peer-reviewed Brain scans and imaging Neuroscience and biobehavioral reviews
Key finding: Third, we describe putative mechanisms proposed to link DMN abnormalities and mental disorders. +4 more findings
Full summary, score breakdown and related studies → Original source
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2008-09-08
Selective induction of calcineurin activity and signaling by oligomeric amyloid beta
36/100 ✓ Peer-reviewed Disease mechanisms Aging cell
Key finding: Although the presence of plaques of fibrillar aggregates of the amyloid beta peptide (Abeta) is a signature of AD, evidence suggests that the preplaque small oligomeric Abeta promotes both synaptic dysfunction and neuronal death. +4 more findings
Full summary, score breakdown and related studies → Original source
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2008-09-07
Causes of death in elderly nursing home residents
36/100 ✓ Peer-reviewed End-of-life care Journal of the American Medical Directors Association
Key finding: The single most common cause of death occurring within the nursing home was Alzheimer's, with most dying appropriately on hospice care. +1 more finding
Full summary, score breakdown and related studies → Original source
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2008-09-06
BDNF is a novel marker of cognitive function in ageing women: the DR's EXTRA Study
47/100 ✓ Peer-reviewed Drug development Neurobiology of learning and memory
Key finding: BDNF was not associated with cognition in men. +1 more finding
Full summary, score breakdown and related studies → Original source
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2008-09-02
Glucocorticoids trigger Alzheimer disease-like pathobiochemistry in rat neuronal cells expressing human tau
43/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of neurochemistry
Key finding: Abnormal APP metabolism leads to the generation of neurotoxic amyloid beta (Abeta), whereas tau hyperphosphorylation culminates in cytoskeletal disturbances, neuronal dysfunction and death. +3 more findings
Full summary, score breakdown and related studies → Original source
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2008-09 month only
Urinary and fecal incontinence in nursing home residents
45/100 ✓ Peer-reviewed Health systems and care delivery Gastroenterology clinics of North America
Key finding: This article reviews the results of studies that have documented how prompted voiding programs can significantly reduce urinary and fecal incontinence, particularly if the intervention includes dietary and exercise components.
Full summary, score breakdown and related studies → Original source
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2008-09-01
Dying with advanced dementia in long-term care geriatric institutions: a retrospective study
40/100 ✓ Peer-reviewed End-of-life care Journal of palliative medicine
Key finding: Some indicators imply a less than optimal quality of care (restraints, pressure sores, psychoactive drugs, and the lack of documentation of shared decision-making) and suggest that far advanced demented patients are not fully perceived as "terminal." +1 more finding
Full summary, score breakdown and related studies → Original source
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2008-09-01
Utility of different MR modalities in mild cognitive impairment and its use as a predictor of conversion to probable dementia
59/100 ✓ Peer-reviewed Biomarkers Academic radiology
Key finding: Rationale and objectives Mild cognitive impairment has been regarded as a pre-Alzheimer condition, but some patients do not develop dementia. +2 more findings
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2008-09-01
Effect of hippocampal and amygdala volumes on clinical outcomes in major depression: a 3-year prospective magnetic resonance imaging study
52/100 ✓ Peer-reviewed Hippocampus size on brain scans Journal of psychiatry & neuroscience : JPN
Key finding: Overall, our results suggest that a relatively small hippocampal volume may be a vulnerability factor for a bad treatment response in major depression. +4 more findings
Full summary, score breakdown and related studies → Original source
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2008-09-01
Mutations in TREM2 lead to pure early-onset dementia without bone cysts
44/100 ✓ Peer-reviewed TREM2 and immune genetics Human mutation
Key finding: A unique locus homozygous by descent at chromosome 6p21.2 locus was identified. +3 more findings
Full summary, score breakdown and related studies → Original source
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2008-09-01
Peripheral oxidative damage in mild cognitive impairment and mild Alzheimer's disease
40/100 ✓ Peer-reviewed Mild cognitive impairment Journal of Alzheimer's disease : JAD
Key finding: In mild AD patients, the plasma levels of vitamin E were significantly decreased, while the plasma concentration of oxidized glutathione was increased in both MCI and mild AD patients. +1 more finding
Full summary, score breakdown and related studies → Original source
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2008-09-01
The four-factor model of depressive symptoms in dementia caregivers: a structural equation model of ethnic differences
46/100 ✓ Peer-reviewed Disparities Psychology and aging
Key finding: Previous studies have suggested that 4 latent constructs (depressed affect, well-being, interpersonal problems, somatic symptoms) underlie the item responses on the Center for Epidemiological Studies Depression (CES-D) Scale. +2 more findings
Full summary, score breakdown and related studies → Original source
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2008-09-01
Attitudes and support needs of Black Caribbean, south Asian and White British carers of people with dementia in the UK
43/100 ✓ Peer-reviewed Disparities The British journal of psychiatry : the journal of mental science
Key finding: The findings suggest that specific cultural attitudes towards the caregiving role have important implications for how carers can best be supported. +1 more finding
Full summary, score breakdown and related studies → Original source
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2008-09-01
Racial and ethnic disparities in the treatment of dementia among Medicare beneficiaries
40/100 ✓ Peer-reviewed Disparities The journals of gerontology. Series B, Psychological sciences and social sciences
Key finding: After adjusting for demographics, socioeconomics, health care access and utilization, comorbidities, and service year, we found that anti-dementia medication use was approximately 30% higher among non-Hispanic Whites compared to other racial/ethnic groups (PR=0.73, 95% confidence interval [CI]=0.59, 0.91). +2 more findings
Full summary, score breakdown and related studies → Original source
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2008-09-01
Coping strategies, anxiety and depression in caregivers of people with Alzheimer's disease
57/100 ✓ Peer-reviewed Caregiving International journal of geriatric psychiatry
Key finding: Using emotion-focussed coping strategies in response to caregiver burden seemed to protect caregivers from developing higher anxiety levels a year later; however using problem-focussed strategies did not. +1 more finding
Full summary, score breakdown and related studies → Original source
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2008-09-01
Imaging amyloid deposition in Lewy body diseases
57/100 ✓ Peer-reviewed Caregiving Neurology
Key finding: Global cortical amyloid burden is high in dementia with Lewy bodies (DLB) but low in Parkinson disease dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
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2008-09-01
MRI correlates of neurofibrillary tangle pathology at autopsy: a voxel-based morphometry study
53/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: Patterns of gray matter loss are associated with neurofibrillary tangle (NFT) pathology, specifically with NFT burden at Braak stages III and IV and with Braak stage itself at higher stages. +3 more findings
Full summary, score breakdown and related studies → Original source
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2008-09-01
Prophylactic oophorectomy in premenopausal women and long-term health
51/100 ✓ Peer-reviewed Prevention and risk Menopause international
Key finding: The potential adverse effects of prophylactic bilateral oophorectomy on heart health, neurological health, bone health and quality of life should be carefully weighed against its potential benefits for cancer risk reduction in women at average risk of ovarian cancer. +2 more findings
Full summary, score breakdown and related studies → Original source
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2008-09-01
Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial
80/100 ✓ Peer-reviewed Treatments JAMA
Key finding: In this study of adults with subjective memory impairment, a 6-month program of physical activity provided a modest improvement in cognition over an 18-month follow-up period. +2 more findings
Full summary, score breakdown and related studies → Original source
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2008-09-01
Correlating cerebral hypometabolism with future memory decline in subsequent converters to amnestic pre-mild cognitive impairment
53/100 ✓ Peer-reviewed Genetics Archives of neurology
Key finding: Individuals with amnestic pre-MCI showed significantly greater correlations between cerebral hypometabolism and subsequent long-term memory decline than nondecliners in Alzheimer disease-affected brain regions. +4 more findings
Full summary, score breakdown and related studies → Original source
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2008-09-01
Cerebral small vessel disease-induced apolipoprotein E leakage is associated with Alzheimer disease and the accumulation of amyloid beta-protein in perivascular astrocytes
39/100 ✓ Peer-reviewed Genetics Journal of neuropathology and experimental neurology
Key finding: Microvascular changes are also associated with AD and have been discussed as a possible reason for altered perivascular drainage. +4 more findings
Full summary, score breakdown and related studies → Original source
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